全部 标题 作者
关键词 摘要


Measurement of D-Dimer Levels in Hyperthyroidism Patients

DOI: 10.4236/oalib.1102772, PP. 1-5

Subject Areas: Hematology

Keywords: Hyperthyroidism, Coagulation, D-Dimer, Sudan

Full-Text   Cite this paper   Add to My Lib

Abstract

Background: Haemostaticab normalities were associated with hyper thyrodism patients. This study aimed to assess the D-dimer levels which indicate the hypercoagulable state in Sudanese patients with hyper thyrodism. Material and Methods: A descriptive analytical case study was conducted in faculty of medical laboratory science, Alneelain University, Khartoum, Sudan. A total of 80 participants were selected for this study, 40 of them were patient known diagnosed by hyperthyroidism as a test group; 20 (50%) were female and 20 (50%) were male; their mean age 36.3 years. Other 40 participants were normal healthy individual as control group. The plasma D-dimer level was measured by using semi-automated coagulometer (MISPA-i2Reagent-SWITZERLAND). Data were analyzed by using statistical package for social sciences (SPSS) Version 20. Results: In this study, the plasma D-dimer level has statistically significantly higher in hyperthyroidism patient compared to normal healthy control group (mean ± SD 0.5008 ± 0.239 vs. 0.5 ± 0.618 mg/dl with P value 0.00), respectively. Conclusions: The present study revealed that the D-dimer levels were statistically significant higher in hyper thyroid patients.

Cite this paper

Mohmed, H. A. and Mohammed, N. E. A. (2016). Measurement of D-Dimer Levels in Hyperthyroidism Patients. Open Access Library Journal, 3, e2772. doi: http://dx.doi.org/10.4236/oalib.1102772.

References

[1]  Adam, S.S., Key, N.S. and Greenberg, C.S. (2009) Prospects. Blood, 113, 2878-2887.
http://dx.doi.org/10.1182/blood-2008-06-165845
[2]  (2011) General Practice Notebook > D-Dimer.
[3]  Suzuki, T., Distante, A. and Eagle, K. (2010) Biomarker-Assisted Diagnosis of Acute Aortic Dissection: How Far We Have Come and What to Expect. Current Opinion in Cardiology, 25, 541-545.
http://dx.doi.org/10.1097/HCO.0b013e32833e6e13
[4]  Wells, P.S., Anderson, D.R., Rodger, M., Forgie, M., Kearon, C., Dreyer, J., Kovacs, G., Mitchell, M., Lewandowski, B. and Kovacs, M.J. (2003) Evaluation of D-Dimer in the Diagnosis of Suspected Deep-Vein Thrombosis. The New England Journal of Medicine, 349, 1227-1235.
http://dx.doi.org/10.1056/NEJMoa023153
[5]  Ogbera, A.O. and Kuku, S.F. (2011) Epidemiology of Thyroid Diseases in Africa. Indian Journal of Endocrinology and Metabolism, 15, S82-S88.
http://dx.doi.org/10.4103/2230-8210.83331
[6]  Bahn, R.S., et al. (2011) Hyperthyroidism and Other Causes of Thyrotoxicosis: Management Guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid, 21, 593-646.
http://dx.doi.org/10.1089/thy.2010.0417
[7]  Devereaux, D. and Tewelde, S.Z. (2014) Hyperthyroidism and Thyrotoxicosis. Emergency Medicine Clinics of North America, 32, 277-292.
http://dx.doi.org/10.1016/j.emc.2013.12.001
[8]  (2015) Hyperthyroidism.
www.niddk.nih.gov
[9]  Frost, L., Vestergaard, P. and Mosekilde, L. (2004) Hyperthyroidism and Risk of Atrial Fibrillation or Flutter: A Population-Based Study. Archives of Internal Medicine, 164, 1675-1678.
http://dx.doi.org/10.1001/archinte.164.15.1675
[10]  Franchini, M., Lippi, G., Manzato, F., et al. (2010) Thyroid-Associated Autoimmune Coagulation Disorders. Journal of Thrombosis and Thrombolysis, 29, 87-91.
http://dx.doi.org/10.1007/s11239-009-0327-1
[11]  Hoylaerts, M.F., Thys, C., Arnout, J., et al. (1998) Recurrent Arterial Thrombosis LINKED to Autoimmune Antibodies Enhancing von Willebrand Factor Binding to Platelets and inducing Fc Gamma RII Receptor-Mediated Platelet Activation. Blood, 91, 2810-2817.
[12]  Squizzato, A., Romualdi, E., Buller, H.R., et al. (2007) Clinical Review: Thyroid Dysfunction and Effects on Coagulation and Fibrinolysis: A Systematic Review. The Journal of Clinical Endocrinology & Metabolism, 92, 2415-2420.
http://dx.doi.org/10.1210/jc.2007-0199
[13]  Vescovi, P.P., Favaloro, E.J., Lippi, G., et al. (2011) The Spectrum of Coagulation Abnormalities in Thyroid Disorders. Seminars in Thrombosis and Hemostasis, 37, 7-10.
http://dx.doi.org/10.1055/s-0030-1270065
[14]  Lip, G.Y. and Lowe, G.D. (1995) Fibrin D-Dimer: A Useful Clinical Marker of Thrombogenesis? Clinical Science, 89, 205-214.
http://dx.doi.org/10.1042/cs0890205
[15]  Chadarevian, R., Bruckert, E., Leenhardt, L., et al. (2001) Components of the Fibrin Lytic System Are Differently Altered In Moderate and Severe Hypothyroidism. The Journal of Clinical Endocrinology & Metabolism, 86, 732-737.
http://dx.doi.org/10.1210/jcem.86.2.7221
[16]  Debeij, J., Suzanne, C.C., van Zaane, B., et al. (2010) The Effect of Changes in Thyroxine and Thyroid Stimulating Hormone Levels on the Coagulation System. Journal of Thrombosis and Haemostasis, 8, 2823-2826.
http://dx.doi.org/10.1111/j.1538-7836.2010.04054.x
[17]  Erem, C., Ersoz, H.O., Karti, S.S., et al. (2002) Blood Coagulation and Fibrinolysis in Patients with Hyperthyroidism. Journal of Endocrinological Investigation, 25, 345-350.
http://dx.doi.org/10.1007/bf03344016
[18]  Burggraaf, J., Lalezari, S., Emeis, J.J., et al. (2001) Endothelial Function in Patients with Hyperthyroidism before and after Treatment with Propranolol and Thiamazol. Thyroid, 11, 153-160.
http://dx.doi.org/10.1089/105072501300042820
[19]  Yango, J., Alexopoulou, O., Eeckhoudt, S., et al. (2011) Evaluation of the Respective Influence of Thyroid Hormones and TSH on Blood Coagulation Parameters after Total Thyroidectomy. European Journal of Endocrinology, 164, 599- 603.
http://dx.doi.org/10.1530/EJE-10-0837

Full-Text


comments powered by Disqus