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Search Results: 1 - 10 of 3544 matches for " postmortem diffusion "
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Postmortem Changes in Myoglobin Content in Organs
Miura,Masanobu,Naka,Toru,Miyaishi,Satoru
Acta Medica Okayama , 2011,
Abstract: Postmortem changes in myoglobin concentrations in blood and organs were investigated using an enzyme immunoassay by animal experiments in combination with immunohistochemical staining of human cases. Blood myoglobin concentrations were found to increase drastically within a very short time after death. Those in striated muscle, however, did not change by day 14 postmortem. Myoglobin content in the liver and kidney increased slightly by day 5 postmortem, and more obviously by day 7 or later. However, almost no change was observed by day 5 in the kidney when the renal artery and vein had been ligated just after death. In the thyroid gland and the lung, the myoglobin content markedly increased by day 7 postmortem, with the logarithmical values rising nearly linearly as the time after death passed. In the thyroid gland, concentrations reached the level of the striated muscle. The mechanisms of postmortem myoglobin increase in organs are thought to be direct diffusion from the striated muscle and/or distribution through the blood. To estimate the postmortem interval, the determination of myoglobin content in the thyroid gland or the lung appears to be useful.
Some worlds about postmortem blood atropine concentrations  [PDF]
Phak-Rop Pos Pok
Forensic Medicine and Anatomy Research (FMAR) , 2013, DOI: 10.4236/fmar.2013.13007
Abstract: Atropine is an anticholinergic drug, used in treatment of spasm and pain. Postmortem blood atropine concentrations tend to be regionally
dependent. We reported in this work the analytical findings of atropine in the peripheral and heart blood from a case of suspected death. Atropine was determined in both peripheral and heart blood by liquid chromatography with tandem mass spectrometry. Towards the reference ranges, the concentration of atropine in the peripheral blood is therapeutic, and in the heart blood is lethal. The high concentration of atropine in the heart blood reflects postmortem redistribution rather than cardiotoxicity. The findings have great implications for forensic toxicology.
Bioquímica postmortem: comparación de tres métodos de análisis
Arroyo,A.; Carbone,MT.; Ordó?ez,J.;
Cuadernos de Medicina Forense , 2004, DOI: 10.4321/S1135-76062004000200005
Abstract: thanatochemistry is an important procedure in forensic medicine. emphasis has been upon fluids that do not alter as quickly as blood, after death. vitreous humor, spinal fluid, pericardic fluid and sinovial fluid have been used. aims: to compare values of cholesterol in blood, glucose and potassium in vitreous humor and creatinkinase in pericardial fluid. the data were obtained from three different methods and analyzers, the third of which was considered as the reference method. materials and methods: samples were obtained from 55 corpses in the pathology department of the legal medicine institute in barcelona. analyzers were: spotchem ez (lab. menarini) dry-chemistry method, spotchem el (lab. menarini) ion selective potenciometry for potassium and reflotron (lab. roche) dry-chemistry method. the reference method analizers were hitachi 911, cobas integra 800 and vitros 259. results: significative differences were found in cholesterol values between the dry chemistry methods and the reference method as well as potassium values between the dry chemistry method and the reference method. no differences were found between the potassium ion selective potenciometry method and the reference method. glucose and creatinkinase results were not considered because of great dispersion values. conclusions: results obtained with the dry-chemistry methods do not allow consideration of its usefullness in forensic practice.
Bioquímica postmortem: comparación de tres métodos de análisis Post-mortem biochemistry: a comparison of three analytical methods
A. Arroyo,MT. Carbone,J. Ordó?ez
Cuadernos de Medicina Forense , 2004,
Abstract: La tanatoquimia es una rama auxiliar importante en medicina forense aunque tiene sus limitaciones. Se ha enfatizado el examen de fluidos que no se alteran con tanta rapidez como la sangre después de la muerte. El humor vítreo, líquido pericárdico, líquido cefalorraquídeo o líquido sinovial se han utilizado con estos fines. Objetivos: comparar los valores de colesterol en sangre, glucosa y potasio en humor vítreo y creatincinasa en líquido pericárdico en tres analizadores y métodos diferentes a fin de validar dos de ellos para análisis postmortem. El tercero se tomó como método de referencia. Material y Métodos: estudio observacional analítico de muestras procedentes de 55 cadáveres que ingresaron para autopsia judicial en el Instituto Anatómico Forense de Barcelona. Los análisis se realizaron en los Analizadores Spotchem EZ (química seca) y Spotchem EL (potenciometría de electrodo ión selectivo, Menarini Diagnostics) y Reflotron (química seca, Roche Diagnostics). Como método de referencia se analizaron las muestras en varios multianalizadores: Hitachi 911, Cobas Integra 800 (ambos de Roche Diagnostic y Vitros 250 Johnson-Johnson). Resultados: se hallaron diferencias significativas entre los valores de colesterol del método de referencia y los dos ensayados. Los valores de potasio presentaron diferencias significativas entre el método de referencia y el de Reflotron pero no entre el valor de referencia y el de Spotchem EZ con r = 0,852. No pudieron evaluarse los valores de glucosa ni de CK por dispersión de valores y dificultad de medición en los dos analizadores ensayados. Conclusiones: los resultados obtenidos con estos dos métodos de química seca, no validados por el fabricante para ensayos postmortem, no permiten considerar su utilidad en el medio forense aunque su utilidad en la práctica clínica está ampliamente documentada. Thanatochemistry is an important procedure in forensic medicine. Emphasis has been upon fluids that do not alter as quickly as blood, after death. Vitreous humor, spinal fluid, pericardic fluid and sinovial fluid have been used. Aims: to compare values of cholesterol in blood, glucose and potassium in vitreous humor and creatinkinase in pericardial fluid. The data were obtained from three different methods and analyzers, the third of which was considered as the reference method. Materials and methods: samples were obtained from 55 corpses in the Pathology department of the Legal Medicine Institute in Barcelona. Analyzers were: Spotchem EZ (Lab. Menarini) dry-chemistry method, Spotchem EL (Lab. Menarini) ion selective potenciomet
Expulsión fetal postmortem Postmortem fetal extrusion
E. Lasso,M. Santos,A. Rico,J.V. Pachar
Cuadernos de Medicina Forense , 2009,
Abstract: Un evento extremadamente inusual en patología forense es la "expulsión postmortem de un feto" también denominado parto postmortem. El "parto postmortem" se define como la expulsión de un feto muerto tras el fallecimiento de una mujer embarazada cuando el útero materno muestra claros signos de putrefacción. Se considera que los gases generados en la fase enfisematosa de la putrefacción cadavérica dentro de la cavidad abdominal pueden prolapsar el útero y causar la expulsión total o parcial del feto. Presentamos el caso de una mujer embarazada de siete meses que desapareció y fue hallada muerta varios días más tarde en avanzado estado de putrefacción. Antes de practicar la autopsia se procedió a retirar la ropa interior y se encontró el feto fuera de la cavidad pélvica. Al mismo tiempo se realiza una revisión histórica del tema. An extremely unusual event in forensic pathology is the postmortem fetal extrusion or "coffin birth". It is defined as the expulsion of a dead fetus after the death of a pregnant woman when the maternal uterus shows signs of putrefaction. It is considered that the gases generated during the emphysematous phase of the cadaveric putrefaction may distend the uterus causing partial or total fetal extrusion. We present the case of a seven month pregnant woman who disappeared and was found dead some days later in a state of advanced putrefaction. The fetus was discovered inside the woman’s underwear at the moment of undressing the body before autopsy. At the same time, an historical review of the issue is carried out.
DNA methylation of the Monoamine Oxidases A and B genes in postmortem brains of subjects with schizophrenia  [PDF]
Qiaohui Yang, Keiko Ikemoto, Satoshi Nishino, Junko Yamaki, Yasuto Kunii, Akira Wada, Yoshimi Homma, Shin-Ichi Niwa
Open Journal of Psychiatry (OJPsych) , 2012, DOI: 10.4236/ojpsych.2012.224053
Abstract: Aims: We focused on DNA methylation of the promoter regions of the Monoamine Oxidase (MAO) A and B genes from postmortem brains of subjects with schizophrenia. Methods: We determined levels of DNA methylation using genomic DNA samples purified from four brain areas: prefrontal cortex (PFC), hippocampus, occipital cortex and nucleus accumbens (NAc), by a bisulfite sequencing method from seven normal subjects and six subjects with schizophrenia. Results: Although very few methylated CpGs of the MAOA and MAOB genes were detected in male samples, various DNA methylation patterns were present in female samples, and some differences were found in such patterns between normal subjects and subjects with schizophrenia. In the PFC, the average level of methylation of both genes was significantly higher in subjects with schizophrenia than in normal subjects. The content of highly methylated alleles of the MAOA gene in the NAc was significantly associated with schizophrenia, with similar results obtained for the MAOB gene in both the NAc and PFC. Some CpG sites showed higher levels of methylation in schizophrenia than in normal subjects. Conclusions: Levels of methylation were quite high in NAc and PFC in female subjects with schizophrenia compared with those in female normal subjects.
Expulsión fetal postmortem
Lasso,E.; Santos,M.; Rico,A.; Pachar,J.V.; Lucena,J.;
Cuadernos de Medicina Forense , 2009, DOI: 10.4321/S1135-76062009000100009
Abstract: an extremely unusual event in forensic pathology is the postmortem fetal extrusion or "coffin birth". it is defined as the expulsion of a dead fetus after the death of a pregnant woman when the maternal uterus shows signs of putrefaction. it is considered that the gases generated during the emphysematous phase of the cadaveric putrefaction may distend the uterus causing partial or total fetal extrusion. we present the case of a seven month pregnant woman who disappeared and was found dead some days later in a state of advanced putrefaction. the fetus was discovered inside the woman?s underwear at the moment of undressing the body before autopsy. at the same time, an historical review of the issue is carried out.
Empleo del humor vítreo para la estimación postmortem de la magnesemia en bovinos
RAMIREZ,C. E.; TITTARELLI,C. M.; MATTIOLI,G. A.; LASTA,G. E.;
Archivos de medicina veterinaria , 1998, DOI: 10.4067/S0301-732X1998000100019
Abstract: the diagnosis of hypomagnesemic tetany in cattle is based on the clinical history and on findings of hypomagnesemia. dead animals show no characteristic lesions and postmortem blood samples are not suitable since mg leaks from the tissues into the blood during autolisis. magnesium concentration in vitreous humour (vh) reflects the plasma mg level, and remains unchanged 48 hs postmortem. therefore, it can be used for postmortem estimation of magnesemia. in a local slaughterhouse, 196 samples were obtained from steers. an eye and a matching blood sample were obtained from each animal. magnesium was measured in plasma and vh by atomic absorption spectrometry. magnesium concentration in vh was above plasma concentration in 84% of the samples. correlation coefficient between plasma mg and vh mg was r:0.51 (f: 69.93 for 1 and 195 degrees of freedom, p<0.001). the regression formula was y = 0.541 + 0.395 * x, where y = vh mg and x = plasma mg. although we recommended to bear in mind that any vh mg value below 0.831 mm gl/l, would be consistent with plasma mg levels below 0.741 mmol/l, the use of the regression formula allows only a gross estimation of the plasma mglevels from vh analysis
Diagnostic Contribution of Postmortem Needle Biopsies in Neonates
?zgü Suna CEL?LO?LU,Can CEL?LO?LU,Erdal KURNAZ,Ramazan ?ZDEM?R
Türk Patoloji Dergisi , 2013, DOI: 10.5146/tjpath.2013.01162
Abstract: Objective: We examined the contribution of neonatal postmortem needle biopsy in circumstances of autopsy denial where magnetic resonance imaging cannot be performed.Material and Method: 247 postmortem needle biopsy specimens of 76 neonatal cases who died in the neonatal intensive care ward of a tertiary hospital between 2005 and 2010 and where the family did not give permission for an autopsy were retrospectively evaluated.Results: 90 needle biopsy attempts (36.4%) were unsuccessful among the 247 biopsies. Liver needle biopsies were found to yield the most valuable diagnostic contribution. A total of 53 liver biopsies provided clinical information that contributed to the diagnosis.Conclusion: The postmortem needle biopsy should be applied in all cases in which standard biopsy cannot be performed. Success rates and level of information gained by extrahepatic needle organ biopsies in neonates were found to be quite low whereas needle biopsies of the liver yielded valuable results. We believe it is more appropriate to perform percutaneous postmortem biopsies solely on the liver in neonates.
Distribution of Postmortem Tissue in Acute Endosulfan Poisoining: Case Report
Nebile Daglioglu,Pinar Efeoglu,Mete K. Gulmen,Necmi Cekin
Cukurova Medical Journal , 2013,
Abstract: In this study, we aimed to determine the distribution of endosulfan in the two postmortem cases, who died due to accidental poisoning. The blood, liver, kidney, brain and stomach content samples obtained from cases were studied with Gas Chromatography-Mass Spectrometry (GC/MS). In the biologic samples, endosulfan isomer (α-Endosulfan and β- Endosulfan) and metabolites (endosulfan sulfate and endosulfan ether) levels were examined. The endosulfan concentrations in the blood were determined as: α- endosulfan was 0.47 mg/l and β-endosulfan was 0.05 mg/l in the first case; α-endofulsan was 0.24 mg/l and β-endosulfan was 0.03 mg/l in the second case. The highest levels of endosulfan were found in the stomach contents. The endosulfan concentrations in the stomach contents were determined as: α-endofulsan was 2.4 mg/kg and β-endosulfan was 1.1 mg/kg in the first case, α- endosulfan was 3.4 mg/kg and β-endosulfan was 2.65 mg/kg in the second case. The liver, brain and the kidney; α- endosulfan, β-endosulfan, endosulfan sulfate and endosulfan ether levels of both cases were examined in our studies as well. [Cukurova Med J 2013; 38(3.000): 515-519]
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