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May 19, 2023Open    AccessArticle

Effective drug combination for Caenorhabditis elegans nematodes discovered by output-driven feedback system control technique

Ding, X. Njus, Z. Kong, T. Su, W. Ho, C.-M. Pandey, S.
Infections from parasitic nematodes (or roundworms) contribute to a significant disease burden and productivity losses for humans and livestock. The limited number of anthelmintics (or antinematode drugs) available today to treat these infections are rapidly losing their efficacy as multidrug resistance in parasites becomes a global health challenge. We propose an engineering approach to discover an anthelmintic drug combination that is more potent at killing wild-type Caenorhabditis elegans wor...

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