We report a nematode electrotactic-response valve (NERV) to control the locomotion of Caenorhabditis elegans (C. elegans) in microfluidic devices. This nonmechanical, unidirectional valve is based on creating a confined region of lateral electric field that is switchable and reversible. We observed that C. elegans do not prefer to pass through this region if the field lines are incident to its forward movement. Upon reaching the boundary of the NERV, the incident worms partially penetrate the fi...

Animal Behavior  Zoology  Mathematical Biology  Veterinary Medicine  Cell Biology  Parasitology  Developmental Biology  Evolutionary Studies  Bioengineering  Bioinformatics  Environmental Sciences  Biophysics 

Doi:10.1063/1.3570629

We describe a planar MEMS silicon structure to record ion channel currents in biological cells. The conventional method of performing an electrophysiological experiment, 'patch-clamping', employs a glass micropipette. The micropipette tip is a source of thermal noise because of its inherent, tapered, conical structure, giving rise to a large pipette resistance. This pipette resistance, when coupled with the biological cell capacitance, limits the available bandwidth of single ion channel recordi...

Taxonomy  Microbiology  Biochemistry  Biodiversity  Developmental Biology  Bioengineering  Bioinformatics  Environmental Sciences  Agricultural Science  Computational Biology  Genetics  Cell Biology  Food Science & Technology  Parasitology  Synthetic Biology 

Doi:10.1016/j.sse.2004.05.072

Computer simulations of realistic ion channel structures have always been challenging and a subject of rigorous study. Simulations based on continuum electrostatics have proven to be computationally cheap and reasonably accurate in predicting a channel's behavior. In this paper we discuss the use of a device simulator, SILVACO, to build a solid-state model for KcsA channel and study its steady-state response. SILVACO is a well-established program, typically used by electrical engineers to simula...

Biological Chemistry  Photochemistry  Taxonomy  Medicinal Chemistry  Ecosystem Science  Developmental Biology  Computational Robotics  Complex network models  Artificial Intelligence  Genetics  Theoretical Chemistry  Analytical Chemistry  Neuroscience  Biological Materials  Nanometer Materials  Green Chemistry  Mathematical Biology  Molecular Biology  Microbiology  Biochemistry  Biodiversity  Bioengineering  Bioinformatics  Biophysics  Biotechnology  Functional Materials  Computational Biology  Synthetic Biology 

Doi:10.1016/j.cmpb.2006.08.007

All life forms use a seamless integration of physical and chemical sensing mechanisms to enhance their performance and survival skills. To mimic the integrative sensing abilities found in nature, there is a significant interest in developing wearable devices that can smartly track the physiological and biochemical signals of the human body. Progress in wearable physical sensors has been remarkable giving rise to a number of consumer electronics products meant to measure parameters related to act...

Electric Engineering  Green Chemistry  Electrochemistry  Biological Chemistry  Mathematical Biology  Biochemistry  Bioengineering  Bioinformatics  Fundamentals of Material Science  Biophysics  Environmental Sciences  Functional Materials  Chemical Engineering & Technology  Genomics  Computational Biology  Plant Science  Synthetic Biology  Materials Engineering  Analytical Chemistry 

Doi:10.1016/j.sna.2019.07.020

Rubus fruticosus L. is a shrub famous for its fruit called blackberry fruit or more commonly blackberry. The fruit has medicinal, cosmetic and nutritive value. It is a concentrated source of valuable nutrients, as well as bioactive constituents of therapeutic interest highlighting its importance as a functional food. Besides use as a fresh fruit, it is also used as ingredient in cooked dishes, salads and bakery products like jams, snacks, desserts, and fruit preserves. R. fruticosus contains vit...

Biological Materials  Diabetes & Endocrinology  Green Chemistry  Biological Chemistry  Evidence Based Medicine  Gastroenterology & Hepatology  Toxicology  Taxonomy  Clinical Trials  Biochemistry  Bioinformatics  Biophysics  Environmental Sciences  Agricultural Science  Food Science & Technology  Translational Medicine  Plant Science  Analytical Chemistry 

Doi:10.3390/molecules190810998