Total of 5 articles.
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May 19, 2023Open AccessArticle
We describe a planar MEMS silicon structure to record ion channel currents in biological cells. The conventional method of performing an electrophysiological experiment, 'patch-clamping', employs a glass micropipette. The micropipette tip is a source of thermal noise because of its inherent, tapered, conical structure, giving rise to a large pipette resistance. This pipette resistance, when coupled with the biological cell capacitance, limits the available bandwidth of single ion channel recordi...
Taxonomy
Microbiology
Biochemistry
Biodiversity
Developmental Biology
Bioengineering
Bioinformatics
Environmental Sciences
Agricultural Science
Computational Biology
Genetics
Cell Biology
Food Science & Technology
Parasitology
Synthetic Biology
May 19, 2023Open AccessArticle
Computer simulations of realistic ion channel structures have always been challenging and a subject of rigorous study. Simulations based on continuum electrostatics have proven to be computationally cheap and reasonably accurate in predicting a channel's behavior. In this paper we discuss the use of a device simulator, SILVACO, to build a solid-state model for KcsA channel and study its steady-state response. SILVACO is a well-established program, typically used by electrical engineers to simula...
Biological Chemistry
Photochemistry
Taxonomy
Medicinal Chemistry
Ecosystem Science
Developmental Biology
Computational Robotics
Complex network models
Artificial Intelligence
Genetics
Theoretical Chemistry
Analytical Chemistry
Neuroscience
Biological Materials
Nanometer Materials
Green Chemistry
Mathematical Biology
Molecular Biology
Microbiology
Biochemistry
Biodiversity
Bioengineering
Bioinformatics
Biophysics
Biotechnology
Functional Materials
Computational Biology
Synthetic Biology
May 19, 2023Open AccessArticle
Infections from parasitic nematodes (or roundworms) contribute to a significant disease burden and productivity losses for humans and livestock. The limited number of anthelmintics (or antinematode drugs) available today to treat these infections are rapidly losing their efficacy as multidrug resistance in parasites becomes a global health challenge. We propose an engineering approach to discover an anthelmintic drug combination that is more potent at killing wild-type Caenorhabditis elegans wor...
Neuroscience
Marine Biology
Toxicology
Taxonomy
Microbiology
Ecosystem Science
Biodiversity
Developmental Biology
Bioengineering
Environmental Sciences
Animal Behavior
Agricultural Science
Biotechnology
Computational Biology
Food Science & Technology
Parasitology
Plant Science
Synthetic Biology
May 19, 2023Open AccessArticle
In this paper, we present a movement-based assay to observe adaptability in Caenorhabditis elegans locomotion behavior. The assay comprises a series of sinusoidal microchannels with a fixed wavelength and modulating (increasing or decreasing) amplitude. The channel width is comparable to the body diameter of the organism. Worms are allowed to enter the channel from the input port and migrate toward the output port. Within channel sections that closely match the worm's natural undulations, the wo...
Animal Behavior
Agricultural Science
Veterinary Medicine
Parasitology
Plant Science
Soil Science
Biodiversity
Bioengineering
Jul 09, 2015Open AccessArticle
Grewia asiatica L., is a species native to south Asia from Pakistan, east to Cambodia, cultivated primarily for its edible fruit and well-reputed for its diverse medicinal uses. Fruits are a rich source of nutrients such as proteins, amino acids, vitamins, and minerals and contain various bioactive compounds, like anthocyanins, tannins, phenolics and flavonoids. Different parts of this plant possess different pharmacological properties. Leaves have antimicrobial, anticancer, antiplatelet and ant...
Biological Chemistry
Cardiology
Toxicology
Photochemistry
Taxonomy
Medicinal Chemistry
Environmental Sciences
Agricultural Science
Genetics
Food Science & Technology
Nutrition
Analytical Chemistry
Biological Materials
Environmental Chemistry
Green Chemistry
Pharmacology
Public Health
Organic Chemistry
Evidence Based Medicine
Gastroenterology & Hepatology
Microbiology
Global Health
Biochemistry
Biodiversity
Biophysics
Biotechnology
Translational Medicine
Respiratory Medicine
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