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Química Nova  2002 

Estratégia de simplifica??o molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo

DOI: 10.1590/S0100-40422002000700018

Keywords: new cardiotonic derivative, bioactive n-acylhydrazone compound, lassbio-294.

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Abstract:

in this article are described examples of the successful use of molecular simplification strategy in the discovery of new drugs from bioactive natural products and synthetic compounds. the discovery of a new cardiotonic derivative (37, 2-thienylidene-3,4-methylenedioxybenzoylhydrazine; lassbio-294), efficiently synthesized from brazilian natural product and structurally designed by molecular simplification of active pyridazinone compounds reported in the literature, is described. a brief description of the pharmacological profile of this new cardiotonic lead-compound, belonging to the n-acylhydrazone (nah) class, is also reported herein.

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