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Modulation of nociceptive-like behavior in zebrafish (Danio rerio) by environmental stressors

DOI: 10.3922/j.psns.2011.1.017

Keywords: nociception, defensive behavior, fear, anxiety, stress, zebrafish.

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zebrafish have been demonstrated to react consistently to noxious chemical stimuli and present reliable phenotypes of stress, fear, and anxiety. in this article, we describe the modulation of nociceptive-like responses of zebrafish to fear-, stress-, and anxiety-eliciting situations. animals were exposed to an alarm substance, confinement stress, or a novel environment before being injected with 1% acetic acid in the tail. the alarm substance and confinement stress reduced the display of erratic movements and tail-beating behavior elicited by acetic acid. the novelty of the environment, in contrast, increased the frequency of tail-beating behavior. the results suggest that descending modulatory control of nociception exists in zebrafish, with apparent fear- and stress-induced analgesia and anxiety-induced hyperalgesia.


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