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Química Nova  2012 

In vitro trypanocidal evaluation of pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae)

DOI: 10.1590/S0100-40422012000400017

Keywords: schinus terebinthifolius raddi, anacardiaceae, trypanocidal activity.

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Abstract:

essential oils of ripe fruits from schinus terebinthifolius (anacardiaceae), obtained using a pilot extractor and a clevenger apparatus were chemically characterized. due the high amount of (-)- α-pinene in both oils, this monoterpene was tested against the protozoan parasite trypanosoma cruzi, showing a moderate potential (ic50 63.56 μg/ml) when compared to benznidazole (ic50 43.14 μg/ml). otherwise, (-)- α-pinene oxide did not showed anti-trypanosomal activity (ic50 > 400 μg/ml) while (-)-pinane showed an ic50 of 56.50 μg/ml. the obtained results indicated that the epoxydation of α-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity.

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