All Title Author
Keywords Abstract

Publish in OALib Journal
ISSN: 2333-9721
APC: Only $99


Relative Articles

Chemopreventive response of diclofenac, a non-steroidal anti-inflammatory drug in experimental carcinogenesis Respuesta quimiopreventiva del diclofenaco, un fármaco antiinflamatorio no esteroideo en la carcinogénesis de colon experimental

Altered membrane lipid dynamics and chemoprevention by non-steroidal anti inflammatory drugs during colon carcinogenesis

The effect of the non-steroidal anti-inflammatory drug diclofenac sodium on thefetuses of albino mice

Antimicrobial activity of non-steroidal anti-inflammatory drugs with respect to immunological response: Diclofenac sodium as a case study

Non-Steroidal Anti-Inflammatory Drugs in the Carcinogenesis of the Gastrointestinal Tract

P-glycoprotein Modulates Morphine Uptake into the CNS: A Role for the Non-steroidal Anti-inflammatory Drug Diclofenac

Structures, Lipophilicity, Dipole Moments, Acidity and Spectroscopic Properties of Non-Steroidal Anti-Inflammatory Drugs Diclofenac, Bromfenac and Amfenac: A Theoretical Study

Prevalence of Nsaids (Non Steroidal Inflammatory Drugs) as a Chemopreventive Agent in Different Types of Cancer: Retrospective Detail Studies

Evaluation of chemopreventive response of two cycloxygenase-2 inhibitors, etoricoxib and diclofenac in rat colon cancer using FTIR and NMR spectroscopic techniques

Mechanisms of Action of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Mesalazine in the Chemoprevention of Colorectal Cancer


Chemopreventive response of diclofenac, a non-steroidal anti-inflammatory drug in experimental carcinogenesis

Keywords: colon cancer, chemoprevention, diclofenac, apoptosis.

Full-Text   Cite this paper   Add to My Lib


the chemopreventive response was evaluated of nonsteroidal anti-inflammatory drug, diclofenac, a preferential cyclooxygenase-2 (cox-2) inhibitor in 1,2-dimethyhydrazine (dmh)-induced colon cancer in rat model. the signs of neoplasm were evident in the animals receiving 30mg of dmh per kg body weight in a weekly s.c injection for six weeks. the putative biomarker of carcinogenesis was visible in the form of multiple plaque lesions in dmh treatment and then regression seen in those animals which also received an oral dose of diclofenac, 8 mg/kg body weight whereas no such macroscopic neoplastic lesions were seen in the animals receiving diclofenac only or the control animals receiving the vehicle of the drug. histopathological results showed the presence of early aberrant changes in the form of severe dysplasia and also numerous crypt fissions in the apical surface of the colonic mucosa. a very high expression of cox-2 was seen in the colonic epithelium of dmh-treated rats, as analyzed by immunohistochemistry. also, the apoptotic events were assessed by terminal deoxynucleotidyl dutp nick end labeling (tunel) assay, where the dmh group shows few number of tunel positive cells which dramatically increased in the diclofenac treatment. the results suggest that diclofenac could be an effective chemopreventive agent in colon cancer, where perhaps apoptosis plays a very dominant end effect in cancer cell killings.


comments powered by Disqus