All Title Author
Keywords Abstract

PLOS ONE  2012 

Mismatch and G-Stack Modulated Probe Signals on SNP Microarrays

DOI: 10.1371/journal.pone.0007862

Full-Text   Cite this paper   Add to My Lib


Single nucleotide polymorphism (SNP) arrays are important tools widely used for genotyping and copy number estimation. This technology utilizes the specific affinity of fragmented DNA for binding to surface-attached oligonucleotide DNA probes. We analyze the variability of the probe signals of Affymetrix GeneChip SNP arrays as a function of the probe sequence to identify relevant sequence motifs which potentially cause systematic biases of genotyping and copy number estimates.


comments powered by Disqus

Contact Us


微信:OALib Journal