全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
PLOS ONE  2012 

Mismatch and G-Stack Modulated Probe Signals on SNP Microarrays

DOI: 10.1371/journal.pone.0007862

Full-Text   Cite this paper   Add to My Lib

Abstract:

Single nucleotide polymorphism (SNP) arrays are important tools widely used for genotyping and copy number estimation. This technology utilizes the specific affinity of fragmented DNA for binding to surface-attached oligonucleotide DNA probes. We analyze the variability of the probe signals of Affymetrix GeneChip SNP arrays as a function of the probe sequence to identify relevant sequence motifs which potentially cause systematic biases of genotyping and copy number estimates.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133