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Clinics  2011 

High admission levels of γ-glutamyltransferase predict poor myocardial perfusion after primary percutaneous intervention

DOI: 10.1590/S1807-59322011001000010

Keywords: myocardial infarction, no-reflow phenomenon, gamma-glutamyltransferase.

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Abstract:

objective: this retrospective study aimed to investigate the relationship between admission levels of serum y-glutamyltransferase and poor myocardial perfusion after primary percutaneous coronary intervention in patients with acute myocardial infarction. introduction: reperfusion injury caused by free radical release and increased oxidative stress is responsible for the pathophysiology of the no-reflow phenomenon in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention. serum ?-glutamyltransferase is an established marker of increased oxidative stress. methods: the study population consisted of 80 patients (64 men and 16 women, mean age = 67.5 + 6.6 years) with thrombolysis in myocardial infarction 0/1 flow pre-procedurally. the patients were divided into two groups according to thrombolysis in myocardial perfusion grades that were assessed immediately following primary percutaneous coronary intervention. the two groups (group 1 and group 2) each consisted of 40 patients with thrombolysis in myocardial perfusion grades 0-1 and thrombolysis in myocardial perfusion grades 2-3, respectively. results: admission pain to balloon time, ?-glutamyltransferase and creatine kinase-mb isoenzyme levels of group 1 patients were significantly higher than those of group 2 patients. pain to balloon time, ?-glutamyltransferase, peak creatine kinase-mb isoenzyme, low left ventricular ejection fraction and poor pre-procedural thrombolysis in myocardial infarction grade were significantly associated with poor myocardial perfusion by univariate analysis. however, only pain to balloon time and ?-glutamyltransferase levels showed a significant independent association with poor myocardial perfusion by backward logistic regression analysis. adjusted odds ratios were calculated as 4.92 for pain to balloon time and 1.13 for ?-glutamyltransferase. conclusion: high admission ?-glutamyltransferase levels are associated with poor myocardial perfusion in pa

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