bioprospecting, defined as the exploration of biodiversity targeted for commercial purposes, has recently become a potential strategy whereby biodiversity-rich countries can enhance their endogenous capacities to perform s&t activities, especially by interacting with more technologically developed countries. therefore, this work focuses on analyzing the mechanism of international cooperation of a megadiverse country, as colombia, through analysis of 342 jointly authored articles published in journals indexed in isi and scopus, information that is complemented by 12 interviews of colombian group leaders. results thereof evidence that spain is the country with the highest cooperation level with colombia. cooperation with american countries is considered as a third priority and is intensified with the participation of a european country. the poor cooperation among colombian groups creates a disperse research agenda on widely varied topics lacking orientation and strategic priorities.