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Homology modelling and insilico analysis of neuraminidase protein in H1N1 Influenza A virus

DOI: 10.1590/S1516-89132011000100003

Keywords: h1n1, neuraminidase, modelling, in silico analysis.

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Abstract:

in this work, modelling of neuraminidase protein of influenza a virus (a/himeji/1/2009(h1n1)) neuraminidase (na) protein was done using modeller 9v2. modelled structure was submitted to protein model database and could be downloaded using accession number pm0075830. the modelled protein structure was subjected to in silco analysis using various bioinformatics tools. two anti-influenza drugs currently being used to treat infected patients are oseltamivir (tamiflu) and zanamivir (relenza), both of which target the neuraminidase enzyme of the virus. reports of the emergence of drug resistance make the development of new anti-influenza molecules a priority. hence the modelled structure of h1ni neuraminidase could be very useful for in silico analysis of potential neuraminidase inhibitors.

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