introduction. kikuchi-fujimoto's disease is a histiocytic necrotizing lymphadenitis, not frequent in children. case report. nine year-old girl with history of fever, adenomegaly and loss of weight that required a lymph node biopsy which was interpreted as necrotizing lymphadenitis (kikuchi-fujimoto's disease), she responded to anti inflammatory medication but presented a relapse 5 years later. conclusion. kikuchi-fujimoto's disease should be suspected in the patients with fever, lymphadenitis, and weight loss after infectious and malignant etiologies have been ruled out. the definitive diagnosis is skin biopsy.