in the present study the genetic compositon of esquel, city located in the argentinean andean patagonia, was estimated in a population sample. a total of 59 non-related blood donors from the zonal hospital were included. five eritrocitary systems, gm allotypes, amerindian, european and african mitochondrial haplogroups, and the m3 mutation in y chromosome were analysed. a survey was done to obtain genealogical information about the donors. genetic admixture was estimated employing the admix program. protein markers showed the presence of 46.9% for the indigenous component and 1.9% for the african component. amerindians mitochondrial haplogroups represented a 79.6%, no subsaharian lineage was present. 23% of males analysed exhibited the aboriginal variant m3. this difference in the sex-specifi c genetic contribution would reveal a gender asimetry in the population history. the data were compared to those obtained previously in the buenos aires metropolitan area, bahía blanca and comodoro rivadavia and also with migrants to buenos aires coming from the north and the west from the country. genetic admixture showed higher values for the amerindian contribution in the argentinian northwest followed by esquel, where the subsaharian component was the lowest found. when considering uniparental markers the higher percentages of autoctonal lineages were observed in esquel and the north of the country, although the patagonic village presented the highest paternal native component considering all the samples analysed, probably due to the late incorporation of the patagonian region to the national state, keeping the autoctonal communities for a longer their authonomy.