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Mitomicina C e "Excimer laser"

DOI: 10.1590/S0004-27492005000600031

Keywords: cornea, wound healing, mitomycin [therapeutic use], refractive errors [surgery], excimer laser photorefractive surgery [methods].

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mitomycin c is an antimetabolite agent that blocks dna and rna replication and protein synthesis. it has been used in several ophthalmologic areas, and recently as a modulator of corneal wound healing in excimer laser surgeries. a single application of mitomycin c during surface corneal photoablative surgery seems a safe and efficient therapeutic option for eyes with corneal opacity and/or as prophylaxis in eyes with high risk for corneal opacity development. the use of this drug in photoablative surgery should be cautious until long-term safety results have been reported. the present text presents a review about corneal wound healing with the use of mitomycin c.


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