Background Healthy lifestyle including sufficient physical activity may mitigate or prevent adverse long-term effects of childhood cancer. We described daily physical activities and sports in childhood cancer survivors and controls, and assessed determinants of both activity patterns. Methodology/Principal Findings The Swiss Childhood Cancer Survivor Study is a questionnaire survey including all children diagnosed with cancer 1976–2003 at age 0–15 years, registered in the Swiss Childhood Cancer Registry, who survived ≥5years and reached adulthood (≥20years). Controls came from the population-based Swiss Health Survey. We compared the two populations and determined risk factors for both outcomes in separate multivariable logistic regression models. The sample included 1058 survivors and 5593 controls (response rates 78% and 66%). Sufficient daily physical activities were reported by 52% (n = 521) of survivors and 37% (n = 2069) of controls (p<0.001). In contrast, 62% (n = 640) of survivors and 65% (n = 3635) of controls reported engaging in sports (p = 0.067). Risk factors for insufficient daily activities in both populations were: older age (OR for ≥35years: 1.5, 95CI 1.2–2.0), female gender (OR 1.6, 95CI 1.3–1.9), French/Italian Speaking (OR 1.4, 95CI 1.1–1.7), and higher education (OR for university education: 2.0, 95CI 1.5–2.6). Risk factors for no sports were: being a survivor (OR 1.3, 95CI 1.1–1.6), older age (OR for ≥35years: 1.4, 95CI 1.1–1.8), migration background (OR 1.5, 95CI 1.3–1.8), French/Italian speaking (OR 1.4, 95CI 1.2–1.7), lower education (OR for compulsory schooling only: 1.6, 95CI 1.2–2.2), being married (OR 1.7, 95CI 1.5–2.0), having children (OR 1.3, 95CI 1.4–1.9), obesity (OR 2.4, 95CI 1.7–3.3), and smoking (OR 1.7, 95CI 1.5–2.1). Type of diagnosis was only associated with sports. Conclusions/Significance Physical activity levels in survivors were lower than recommended, but comparable to controls and mainly determined by socio-demographic and cultural factors. Strategies to improve physical activity levels could be similar as for the general population.
Diller L, Chow EJ, Gurney JG, Hudson MM, Kadin-Lottick NS, et al. (2009) Chronic Disease in the Childhood Cancer Survivor Study Cohort: A Review of Published Findings. Journal of Clinical Oncology 27: 2339–2355.
Reulen RC, Winter DL, Frobisher C, Lancashire ER, Stiller CA, et al. (2010) Long-term Cause-Specific Mortality Among Survivors of Childhood Cancer. JAMA: The Journal of the American Medical Association 304: 172–179.
Blaauwbroek R, Bouma M, Tuinier W, Groenier K, de Greef M, et al. (2009) The effect of exercise counselling with feedback from a pedometer on fatigue in adult survivors of childhood cancer: a pilot study. Supportive Care in Cancer 17: 1041–1048.
Hartman A, Winkel MLt, Beek RDv, Keizer-Schrama SMPFdM, Kemper HCG, et al. (2009) A randomized trial investigating an exercise program to prevent reduction of bone mineral density and impairment of motor performance during treatment for childhood acute lymphoblastic leukemia. Pediatric Blood & Cancer 53: 64–71.
Mayer EIE, Reuter M, Dopfer RE, Ranke MB (2000) Energy Expenditure, Energy Intake and Prevalence of Obesity after Therapy for Acute Lymphoblastic Leukemia during Childhood. Hormone Research in Paediatrics 53: 193–199.
Meacham LR, Chow EJ, Ness KK, Kamdar KY, Chen Y, et al. (2010) Cardiovascular Risk Factors in Adult Survivors of Pediatric Cancer—A Report from the Childhood Cancer Survivor Study. Cancer Epidemiology Biomarkers & Prevention 19: 170–181.
Tillmann V, Darlington ASE, Eiser C, Bishop NJ, Davies HA (2002) Male Sex and Low Physical Activity Are Associated With Reduced Spine Bone Mineral Density in Survivors of Childhood Acute Lymphoblastic Leukemia. Journal of Bone and Mineral Research 17: 1073–1080.
Speck R, Courneya K, Masse L, Duval S, Schmitz K (2010) An update of controlled physical activity trials in cancer survivors: a systematic review and meta-analysis. Journal of Cancer Survivorship 4: 87–100.
Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, Galvao DA, et al. (2010) American College of Sports Medicine Roundtable on Exercise Guidelines for Cancer Survivors. Medicine & Science in Sports & Exercise 42: 1409–1426.
Naylor AS, Bull C, Nilsson MKL, Zhu C, Bj？rk-Eriksson T, et al. (2008) Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young mouse brain. Proceedings of the National Academy of Sciences 105: 14632–14637.
Haskell WL, Lee IM, Pate RR, Powel KE, Bair SN, et al. (2007) Physical Activity and Public Health: Updated Recommendation for Adults from the American College of Sports Medicine and the American Heart Association. Medicine & Science in Sports & Exercise 39: 1423–1434.
Samitz G, Egger M, Zwahlen M (2011) Domains of physical activity and all-cause mortality: systematic review and dose–response meta-analysis of cohort studies. International Journal of Epidemiology 40: 1382–1400.
Florin TA, Fryer GE, Miyoshi T, Weitzman M, Mertens AC, et al. (2007) Physical Inactivity in Adult Survivors of Childhood Acute Lymphoblastic Leukemia: A Report from the Childhood Cancer Survivor Study. Cancer Epidemiology Biomarkers & Prevention 16: 1356–1363.
J？rvel？ LS, Niinikoski H, L？hteenm？ki PM, Heinonen OJ, Kapanen J, et al. (2010) Physical activity and fitness in adolescent and young adult long-term survivors of childhood acute lymphoblastic leukaemia. J Cancer Surviv 4: 339–345.
Michel G, von der Weid NX, Zwahlen M, Adam M, Rebholz CE, et al. (2007) The Swiss Childhood Cancer Registry: rationale, organisation and results for the years 2001–2005. Swiss Medical Weekly 137: 502–509.
Feller M, Adam M, Zwahlen M, Brazzola P, Niggli F, et al. (2010) Family Characteristics as Risk Factors for Childhood Acute Lymphoblastic Leukemia: A Population-Based Case-Control Study. PLoS ONE 5: e13156.
Hawkins M, Lancashire E, Winter D, Frobisher C, Reulen R, et al. (2008) The British Childhood Cancer Survivor Study: Objectives, methods, population structure, response rates and initial descriptive information. Pediatric Blood & Cancer 50: 1018–1025.
M？kinen T, Kestil？ L, Borodulin K, Martelin T, Rahkonen O, et al. (2010) Effects of childhood socio-economic conditions on educational differences in leisure-time physical activity. The European Journal of Public Health 20: 346–353.
San Juan AF, Chamorro-Vi？a C, Moral S, Fernández del Valle M, Madero L, et al. (2008) Benefits of Intrahospital Exercise Training after Pediatric Bone Marrow Transplantation. Int J Sports Med 29: 439–446.
Barr-Anderson DJ, AuYoung M, Whitt-Glover MC, Glenn BA, Yancey AK (2011) Integration of Short Bouts of Physical Activity Into Organizational Routine: A Systematic Review of the Literature. American Journal of Preventive Medicine 40: 76–93.
US Department of Health and Human Services (1996) Physical Activity and Health: A Report of the Surgeon General. Washington, DC: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion.