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New bioactive metabolites produced by Phomopsis cassiae, an endophytic fungus in Cassia spectabilis

DOI: 10.1590/S0103-50532005000800029

Keywords: endophytic fungi, phomopsis cassiae, cassia spectabilis, cytotoxic metabolites, antifungal activity.

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two new metabolites, ethyl 2,4-dihydroxy-5,6-dimethylbenzoate (1) and phomopsilactone (2) were isolated from phomopsis cassiae, an endophytic fungus in cassia spectabilis. their structures were elucidated by 1d and 2d nmr, ms and ir spectral data. compounds 1 and 2 displayed strong antifungal activity against the phytopatogenic fungi cladosporium cladosporioides and c. sphaerospermum, as well as cytotoxicity against human cervical tumor cell line (hela), in in vitro assays.


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