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As bases neurobiológicas do transtorno obsessivo-compulsivo e da síndrome de Tourette

DOI: 10.1590/S0021-75572004000300006

Keywords: obsessive-compulsive disorder, tourette syndrome, tic disorders, neuroscience.

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objective: to describe and discuss evidence-based articles on the neurobiology of obsessive-compulsive disorder and tourette syndrome. sources of data: a review of the most relevant papers on the phenomenology, neuroanatomy, neuroimaging, genetic and immunological aspects of these two disorders was performed. summary of the findings: ritualistic behaviors and repetitive thoughts have been extensively studied in the last years. the definitions of obsessive-compulsive disorder and tourette syndrome emphasize the existence of a continuum of symptoms, with high prevalence in the general population. neurobiological findings have implicated genetic and immunological factors in the etiology of these two disorders. conclusions: advances in neuroscience triggered genetic and immunological research studies, allowing new perspectives on the treatment of obsessive-compulsive disorder and tourette syndrome patients.


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