All Title Author
Keywords Abstract

Publish in OALib Journal
ISSN: 2333-9721
APC: Only $99


Relative Articles

Efficacy evaluation of a test CINtec® p16INK4a in screening for cervical HPV infection

Efficacy of Vaccination against HPV Infections to Prevent Cervical Cancer in France: Present Assessment and Pathways to Improve Vaccination Policies

Promoter Methylation of p16INK4A, hMLH1, and MGMT in Liquid-Based Cervical Cytology Samples Compared with Clinicopathological Findings and HPV Presence

Detección de virus papiloma humano (HPV) a partir de muestras celulares de cuello uterino en base líquida: Correlación con la inmunorreactividad de la proteína p16INK4a Detection of human papilloma virus (HPV) in liquid-based cervical samples: Correlation with protein p16INK4a expression

Reliability of the CINtecTM p16INK4a immunocytochemical test in screening cervical precancerous lesions

Guidelines of the Italian Society for Virology on HPV testing and vaccination for cervical cancer prevention

Efficacy and Safety of Prophylactic Vaccines against Cervical HPV Infection and Diseases among Women: A Systematic Review & Meta-Analysis

Human papillomavirus (HPV) vaccination for the prevention of HPV 16/18 induced cervical cancer and its precursors

Detection of HPV and the role of p16INK4A overexpression as a surrogate marker for the presence of functional HPV oncoprotein E7 in colorectal cancer

Role of Protein Biomarkers in the Detection of High-Grade Disease in Cervical Cancer Screening Programs

Efficacy in treatment of subclinical cervical HPV infection without intraepithelial neoplasia: systematic review


Efficacy evaluation of a test CINtec® p16INK4a in screening for cervical HPV infection

DOI: 10.4236/ojpm.2011.13020, PP. 154-163

Keywords: Screening, Cervical Infection, HPV Test

Full-Text   Cite this paper   Add to My Lib


We submitted 437 patients with cytological alterations that suggest viral infections to HPV test. 154 patients (35.24%) resulted positive for HPV; among these, 128 (83.11%) with a low degree of infectivity, 19 (12.33%), with an average degree of infectivity and 7 (4.54%) with a high degree of infectivity).


[1]  IARC Working Group (1995) IARC Monographs on the evaluation of carcinogenic risks to humans. International Agency for Research on Cancer, Lyon, 64.
[2]  Frazer, I.H., Cox, J.T., Mayeaux, E.J., Franco, E.L., et al. (2006) Advances in prevention of cervical cancer and other human papillomavirus-related diseases. Pediatric Infectious Disease Journal, 25, S65-S81. doi:10.1097/01.inf.0000196485.86376.46
[3]  Munger, K., et al. (1989) The E6 and E7 genes of the human papillomavius type 16 together are necessary and sufficient for transformation of primary human keratinocytes. Journal of Virology, 63, 4417-4421.
[4]  Zur-Hausen, H., de Villiers, E.M. (1994) Human papillomaviruses. Annual Review of Microbiology, 48, 427- 447. doi:10.1146/annurev.mi.48.100194.002235
[5]  Zur-Hausen H., (2000) Papillomaviruses causing cancer: Evasion from host-cell control in early events in carcinogenesis. Journal of the National Cancer Institute, 92, 690-698. doi:10.1093/jnci/92.9.690
[6]  Von Knebel-Doeberitz, M. (2002) New markers for cervical dysplasia to visualize the genomic chaos created by aberrant oncogenic papillomavirus infections. European Journal of Cancer, 38, 2229-2242. doi:10.1016/S0959-8049(02)00462-8
[7]  Benevolo, M., et al. (2006) Immunohistochemical expression of p16INK4a is predictive of HR-HPV infection in cervical low-grade lesion. Modern Pathology, 19, 384- 391. doi:10.1038/modpathol.3800551
[8]  Passamonti, B., et al. (2006) P16: A method for directed research on abnormal convenzional pap-test. Pathologica, 98, 417.
[9]  Bibbo, M., et al. (2002) Procedure for immunocytochemical detection of p16INK4a antigen in thin-layer, liquid-based specimens. Acta Cytologica, 46, 25-29. doi:10.1159/000326711
[10]  Nicolas, W., et al. (2009) Triage of women with ASCUS and LSIL cytology. Cancer Epidemiol Biomarkers Prevention, 18, 1341-1349.
[11]  Meyer, J.L., et al. (2007) Evalution of p16INK4 expression in thin-prep cervical specimens with the CINtec? 16INK4a assay. Cancer Cytopathology, 11, 83-92.


comments powered by Disqus