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Efficacy evaluation of a test CINtec® p16INK4a in screening for cervical HPV infection

DOI: 10.4236/ojpm.2011.13020, PP. 154-163

Keywords: Screening, Cervical Infection, HPV Test

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Abstract:

We submitted 437 patients with cytological alterations that suggest viral infections to HPV test. 154 patients (35.24%) resulted positive for HPV; among these, 128 (83.11%) with a low degree of infectivity, 19 (12.33%), with an average degree of infectivity and 7 (4.54%) with a high degree of infectivity).

References

[1]  IARC Working Group (1995) IARC Monographs on the evaluation of carcinogenic risks to humans. International Agency for Research on Cancer, Lyon, 64.
[2]  Frazer, I.H., Cox, J.T., Mayeaux, E.J., Franco, E.L., et al. (2006) Advances in prevention of cervical cancer and other human papillomavirus-related diseases. Pediatric Infectious Disease Journal, 25, S65-S81. doi:10.1097/01.inf.0000196485.86376.46
[3]  Munger, K., et al. (1989) The E6 and E7 genes of the human papillomavius type 16 together are necessary and sufficient for transformation of primary human keratinocytes. Journal of Virology, 63, 4417-4421.
[4]  Zur-Hausen, H., de Villiers, E.M. (1994) Human papillomaviruses. Annual Review of Microbiology, 48, 427- 447. doi:10.1146/annurev.mi.48.100194.002235
[5]  Zur-Hausen H., (2000) Papillomaviruses causing cancer: Evasion from host-cell control in early events in carcinogenesis. Journal of the National Cancer Institute, 92, 690-698. doi:10.1093/jnci/92.9.690
[6]  Von Knebel-Doeberitz, M. (2002) New markers for cervical dysplasia to visualize the genomic chaos created by aberrant oncogenic papillomavirus infections. European Journal of Cancer, 38, 2229-2242. doi:10.1016/S0959-8049(02)00462-8
[7]  Benevolo, M., et al. (2006) Immunohistochemical expression of p16INK4a is predictive of HR-HPV infection in cervical low-grade lesion. Modern Pathology, 19, 384- 391. doi:10.1038/modpathol.3800551
[8]  Passamonti, B., et al. (2006) P16: A method for directed research on abnormal convenzional pap-test. Pathologica, 98, 417.
[9]  Bibbo, M., et al. (2002) Procedure for immunocytochemical detection of p16INK4a antigen in thin-layer, liquid-based specimens. Acta Cytologica, 46, 25-29. doi:10.1159/000326711
[10]  Nicolas, W., et al. (2009) Triage of women with ASCUS and LSIL cytology. Cancer Epidemiol Biomarkers Prevention, 18, 1341-1349.
[11]  Meyer, J.L., et al. (2007) Evalution of p16INK4 expression in thin-prep cervical specimens with the CINtec? 16INK4a assay. Cancer Cytopathology, 11, 83-92.

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