Introduction: Leukocyte and platelet-rich fibrin (L-PRF) is an emerging material in dentistry, however, there are controversies surrounding its effectiveness. Despite the amount of literature available, debates regarding its effect continue. This review aims to summarize and clarify the data surrounding the use of L-PRF in promoting the healing of extraction sockets, which may offer a better outcome for future treatments. Purpose: The purpose of this review is to evaluate the current literature on the use of L-PRF in promoting the healing of extraction sockets, and to provide a comprehensive overview of the available evidence. Methods: A comprehensive computer-based search of databases such as PubMed, Medline, and Cochrane Library was conducted. Results: The results of this review suggest that L-PRF has shown promise in promoting early healing of extraction sockets, but the evidence for its effectiveness over a longer period is limited. Conclusion: Although L-PRF has shown promising results in the early healing periods, its effectiveness over a longer healing period cannot be confirmed based on the available data. More clinical trials with standardized protocols and consistent measurement methods are needed to establish the role of L-PRF in enhancing the healing of extraction sockets.
References
[1]
Awadalkreem, F., Khalifa, N., Satti, A. and Suleiman, A.M. (2020) The Influence of Immediately Loaded Basal Implant Treatment on Patient Satisfaction. International Journal of Dentistry, 2020, Article ID: 6590202. https://doi.org/10.1155/2020/6590202
[2]
Alrabiah, M., Al Deeb, M., Alsahhaf, A., AlFawaz, Y.F., Al-Aali, K.A., Vohra, F., et al. (2020) Clinical and Radiographic Assessment of Narrow-Diameter and Regular-Diameter Implants in the Anterior and Posterior Jaw: 2 to 6 Years of Follow-Up. Journal of Periodontal and Implant Science, 50, 97-105. https://doi.org/10.5051/jpis.2020.50.2.97
[3]
Araújo, M.G., Silva, C.O., Misawa, M. and Sukekava, F. (2015) Alveolar Socket Healing: What Can We Learn? Periodontology 2000, 68, 122-134. https://doi.org/10.1111/prd.12082
[4]
Cawood, J.I. and Howell, R.A. (1988) A Classification of the Edentulous Jaws. International Journal of Oral and Maxillofacial Surgery, 17, 232-236. https://doi.org/10.1016/S0901-5027(88)80047-X
[5]
Esposito, M., Koukoulopoulou, A., Coulthard, P. and Worthington, H.V. (2006) Interventions for Replacing Missing Teeth: Dental Implants in Fresh Extraction Sockets (Immediate, Immediate-Delayed and Delayed Implants). Cochrane Database of Systematic Reviews, 4, CD005968. https://doi.org/10.1002/14651858.CD005968.pub2
[6]
Lops, D., Romeo, E., Chiapasco, M., Procopio, R.M. and Oteri, G. (2013) Behaviour of Soft Tissues Healing around Single Bone-Level-Implants Placed Immediately after Tooth Extraction a 1 Year Prospective Cohort Study. Clinical Oral Implants Research, 24, 1206-1213. https://doi.org/10.1111/j.1600-0501.2012.02531.x
[7]
McAllister, B.S. and Haghighat, K. (2007) Bone Augmentation Techniques. Journal of Periodontology, 78, 377-396. https://doi.org/10.1902/jop.2007.060048
[8]
Juodzbalys, G., Stumbras, A., Goyushov, S., Duruel, O. and Tozüm, T.F. (2019) Morphological Classification of Extraction Sockets and Clinical Decision Tree for Socket Preservation/Augmentation after Tooth Extraction: A Systematic Review. Journal of Oral and Maxillofacial Surgery, 10, e3. https://doi.org/10.5037/jomr.2019.10303
[9]
Tan, Z., Kang, J., Liu, W. and Wang, H. (2018) The Effect of the Heights and Thicknesses of the Remaining Root Segments on Buccal Bone Resorption in the Socket-Shield Technique: An Experimental Study in Dogs. Clinical Implant Dentistry and Related Research, 20, 352-359. https://doi.org/10.1111/cid.12588
[10]
Anwandter, A., Bohmann, S., Nally, M., Castro, A.B., Quirynen, M. and Pinto, N. (2016) Dimensional Changes of the Post Extraction Alveolar Ridge, Preserved with Leukocyte and Platelet Rich Fibrin: A Clinical Pilot Study. Journal of Dentistry, 52, 23-29. https://doi.org/10.1016/j.jdent.2016.06.005
[11]
Artzi, Z., Nemcovsky, C.E. and Dayan, D. (2002) Bovine-HA Spongiosa Blocks and Immediate Implant Placement in Sinus Augmentation Procedures. Histopathological and Histomorphometric Observations on Different Histological Stainings in 10 Consecutive Patients. Clinical Oral Implants Research, 13, 420-427. https://doi.org/10.1034/j.1600-0501.2002.130411.x
[12]
Ghanaati, S., Booms, P., Orlowska, A., Kubesch, A., Lorenz, J., Rutkowski, J., et al. (2014) Advanced Platelet-Rich Fibrin: A New Concept for Cell-Based Tissue Engineering by Means of Infammatory Cells. Journal of Oral Implantology, 40, 679-689. https://doi.org/10.1563/aaid-joi-D-14-00138
[13]
Schar, M.O., Diaz-Romero, J., Kohl, S., Zumstein, M.A. and Nesic, D. (2015) Platelet-Rich Concentrates Differentially Release Growth Factors and Induce Cell Migration in Vitro. Clinical Orthopaedics and Related Research, 473, 1635-1643. https://doi.org/10.1007/s11999-015-4192-2
[14]
Kubesch, A., Barbeck, M., Al-Maawi, S., Orlowska, A., Booms, P.F., Sader, R.A., et al. (2018) A Low-Speed Centrifugation Concept Leads to Cell Accumulation and Vascularization of Solid Platelet-Rich Fibrin: An Experimental Study in Vivo. Platelets, 30, 329-340. https://doi.org/10.1080/09537104.2018.1445835
[15]
Kobayashi, E., Flückiger, L., Fujioka-Kobayashi, M., Sawada, K., Sculean, A., Schaller, B., et al. (2016) Comparative Release of Growth Factors from PRP, PRF, and Advanced-PRF. Clinical Oral Investigations, 20, 2353-2360. https://doi.org/10.1007/s00784-016-1719-1
[16]
Anitua, E., Sánchez, M., Orive, G. and Andía, I. (2017) The Potential Impact of the Preparation Rich in Growth Factors (PRGF) in Different Medical Fields. Biomaterials, 28, 4551-4560. https://doi.org/10.1016/j.biomaterials.2007.06.037
[17]
Dohan, D.M., Choukroun, J., Diss, A., Dohan, S.L., Dohan, A.J.J., Mouhyi, J., et al. (2006) Platelet-Rich Fibrin (PRF): A Second-Generation Platelet Concentrate. Part I: Technological Concepts and Evolution. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 101, e37-e44. https://doi.org/10.1016/j.tripleo.2005.07.008
[18]
Castro, A.B., Van Dessel, J., Temmerman, A., Jacobs, R. and Quirynen, M. (2021) Effect of Different Platelet-Rich Fibrin Matrices for Ridge Preservation in Multiple Tooth Extractions: A Split-Mouth Randomized Controlled Clinical Trial. Journal of Clinical Periodontology, 48, 984-995. https://doi.org/10.1111/jcpe.13463
[19]
de Almeida Barros Mourao, C.F., de Mello-Machado, R.C., Javid, K. and Moraschini, V. (2020) The Use of Leukocyte- and Platelet-Rich Fibrin in the Management of Soft Tissue Healing and Pain in Post-Extraction Sockets: A Randomized Clinical Trial. Journal of Cranio-Maxillofacial Surgery, 48, 452-457. https://doi.org/10.1016/j.jcms.2020.02.020
[20]
dos Canellas, J.V.S., da Costa, R.C., Breves, R.C., de Oliveira, G.P., da Figueredo, C.M.S., Fischer, R.G., et al. (2020) Tomographic and Histomorphometric Evaluation of Socket Healing after Tooth Extraction Using Leukocyte- and Platelet-Rich Fibrin: A Randomized, Single-Blind, Controlled Clinical Trial. Journal of Cranio-Maxillofacial Surgery, 48, 24-32. https://doi.org/10.1016/j.jcms.2019.11.006
[21]
Srinivas, B., Das, P., Rana, M.M., Qureshi, A.Q., Vaidya, K.C., Raziuddin, S.J.A. (2018) Wound Healing and Bone Regeneration in Postextraction Sockets with and without Platelet-Rich Fibrin. Annals of Maxillofacial Surgery, 8, 28-34. https://doi.org/10.4103/ams.ams_153_17
[22]
Ahmed, N., Gopalakrishna, V., Shetty, A., Nagraj, V., Imran, M. and Kumar, P. (2019) Efficacy of PRF vs PRF + Biodegradable Collagen Plug in Post-Extraction Preservation of Socket. Journal of Contemporary Dental Practice, 20, 1323-1328. https://doi.org/10.5005/jp-journals-10024-2673
[23]
Areewong, K., Chantaramungkorn, M. and Khongkhunthian, P. (2019) Platelet-Rich Fibrin to Preserve Alveolar Bone Sockets Following Tooth Extraction: A Randomized Controlled Trial. Clinical Implant Dentistry and Related Research, 21, 1156-1163. https://doi.org/10.1111/cid.12846
[24]
Ustaoglu, G., Goller Bulut, D. and Gümüs, K. (2019) Evaluation of Diferent Platelet-Rich Concentrates Efects on Early Soft Tissue Healing and Socket Preservation after Tooth Extraction. Journal of Stomatology, Oral and Maxillofacial Surgery, 121, 539-544. https://doi.org/10.1016/j.jormas.2019.09.005
[25]
Giudice, A., Esposito, M., Bennardo, F., Brancaccio, Y., Buti, J. and Fortunato, L. (2019) Dental Extractions for Patients on Oral Antiplatelet: A Within-Person Randomised Controlled Trial Comparing Haemostatic Plugs, Advanced Platelet-Rich Fibrin (A-PRF+) Plugs, Leukocyte- and Platelet-Rich Fibrin (L-PRF) Plugs and Suturing Alone. International Journal of Oral Implantology (Berl), 12, 77-87.
[26]
Zhang, Y., Ruan, Z., Shen, M., Tan, L., Huang, W., Wang, L., et al. (2018) Clinical Effect of Platelet-Rich Fibrin on the Preservation of the Alveolar Ridge Following Tooth Extraction. Experimental and Therapeutic Medicine, 15, 2277-2286. https://doi.org/10.3892/etm.2018.5696
[27]
Temmerman, A., Vandessel, J., Castro, A., Jacobs, R., Teughels, W., Pinto, N., et al. (2016) The Use of Leucocyte and Platelet-Rich Fibrin in Socket Management and Ridge Preservation: A Split-Mouth, Randomized, Controlled Clinical Trial. Journal of Clinical Periodontology, 43, 990-999. https://doi.org/10.1111/jcpe.12612
[28]
Marenzi, G., Riccitiello, F., Tia, M., di Lauro, A. and Sammartino, G. (2015) Infuence of Leukocyte- and Platelet-Rich Fibrin (L-PRF) in the Healing of Simple Postextraction Sockets: A Split-Mouth Study. Biomed Research International, 2015, Article ID: 369273. https://doi.org/10.1155/2015/369273
[29]
Suttapreyasri, S. and Leepong, N. (2013) Infuence of Platelet-Rich Fibrin on Alveolar Ridge Preservation. Journal of Craniofacial Surgery, 24, 1088-1094. https://doi.org/10.1097/SCS.0b013e31828b6dc3
[30]
Horowitz, R., Holtzclaw, D. and Rosen, P.S. (2012) A Review on Alveolar Ridge Preservation Following Tooth Extraction. Journal of Evidence-Based Dental Practice, 12, 149-160. https://doi.org/10.1016/S1532-3382(12)70029-5
[31]
Dohan, E.D., de Peppo, G.M., Doglioli, P. and Sammartino, G. (2009) Slow Release of Growth Factors and Thrombospondin-1 in Choukroun’s Platelet-Rich Fibrin (PRF): A Gold Standard to Achieve for All Surgical Platelet Concentrates Technologies. Growth Factors, 27, 63-69. https://doi.org/10.1080/08977190802636713
[32]
Aroca, S., Keglevich, T., Barbieri, B., Gera, I. and Etienne, D. (2009) Clinical Evaluation of a Modified Coronally Advanced Flap Alone or in Combination with a Platelet-Rich Fibrin Membrane for the Treatment of Adjacent Multiple Gingival Recessions: A 6-Month Study. Journal of Periodontology, 80, 244-252. https://doi.org/10.1902/jop.2009.080253
[33]
Jankovic, S., Aleksic, Z., Klokkevold, P., et al. (2012) Use of Platelet-Rich Fibrin Membrane Following Treatment of Gingival Recession: A Randomized Clinical Trial. International Journal of Periodontics and Restorative Dentistry, 32, 41-50.
[34]
Bastami, F. and Khojasteh, A. (2016) Use of Leukocyte- and Platelet-Rich Fibrin for Bone Regeneration: A Systematic Review. Regeneration Reconstruction Restoration, 1, 47-68.
[35]
Moraschini, V. and Barboza, E.S. (2015) Effect of Autologous Platelet Concentrates for Alveolar Socket Preservation: A Systematic Review. International Journal of Oral and Maxillofacial Surgery, 44, 632-641. https://doi.org/10.1016/j.ijom.2014.12.010
[36]
Del Fabbro, M., Bortolin, M. and Taschieri, S. (2011) Is Autologous Platelet Concentrate Beneficial for Post-Extraction Socket Healing? A Systematic Review. International Journal of Oral and Maxillofacial Surgery, 40, 891-900. https://doi.org/10.1016/j.ijom.2011.04.009
[37]
Kotsakis, G.A., Javed, F., Hinrichs, J.E., Karoussis, I.K. and Romanos, G.E. (2015) Impact of Cigarette Smoking on Clinical Outcomes of Periodontal Flap Surgical Procedures: A Systematic Review and Meta-Analysis. Journal of Periodontology, 86, 254-263. https://doi.org/10.1902/jop.2014.140452
[38]
Saldanha, J.B., Casati, M.Z., Neto, F.H., Sallum, E.A. and Nociti, F.J. (2006) Smoking May Affect the Alveolar Process Dimensions and Radiographic Bone Density in Maxillary Extraction Sites: A Prospective Study in Humans. Journal of Oral and Maxillofacial Surgery, 64, 1359-1365. https://doi.org/10.1016/j.joms.2006.05.021
