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Clinical and Pathological Value of MACC-1 Expression in Gastric Carcinoma

DOI: 10.4236/jct.2019.107050, PP. 609-618

Keywords: Gastric Cancer, MACC-1, HGF/MET Signaling

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Abstract:

Background: Gastric adenocarcinoma is known to be a markedly invasive disease with high potential for metastasis. Hepatocyte growth factor (HGF)/HGF receptor (MET) signaling pathway activation is an assumed mechanism of malignant transformation and metastatic potential of tumors. Metastasis associated with colon cancer-1 (MACC-1) has been identified as a key regulator of HGF/MET signaling. However, its role in gastric cancer is not well understood. Aim of this study is to assess the expression of MACC-1 in gastric cancer, its relation to other clinical and pathologic parameters and its impact on progression free and overall survival. Patient and Methods: Evaluation of MACC-1 protein expression by immune-histochemistry

 References

[1]  Duan, J., Chen, L., Zhou, M. and Liao, W. (2017) MACC1 Decreases the Chemosensitivity of Gastric Cancer Cells to Oxaliplatin by Regulating FASN Expression. Oncology Reports, 37, 2583-2592.
https://doi.org/10.3892/or.2017.5519
[2]  Smith, B.R. and Stabile, B.E. (2009) Extreme Aggressiveness and Lethality of Gastric Adenocarcinoma in the Very Young. The Archives of Surgery, 144, 506-510.
https://doi.org/10.1001/archsurg.2009.77
[3]  Ma, J., Ma, J., Meng, Q., Zhao, Z.-S. and Xu, W.-J. (2013) Prognostic Value and Clinical Pathology of MACC-1 and c-MET Expression in Gastric Carcinoma. Pathology & Oncology Research, 19, 821-832.
https://doi.org/10.1007/s12253-013-9650-0
[4]  Okines, A.F., Reynolds, A.R. and Cunningham, D. (2011) Target in Angiogenesis in Esophagogastric Adenocarcinoma. Oncologist, 16, 844-858.
https://doi.org/10.1634/theoncologist.2010-0387
[5]  Lai, L. and Gold Schneider, I. (2001) Cutting Edge: Identification of a Hybrid Cytokine Consisting of IL-7 and the Beta-Chain of the Hepatocyte Growth Consisting of IL-7 and the Beta-Chain of the Hepatocyte Growth Factor/Scatter Factor. Immunology, 167, 3550-3554.
https://doi.org/10.4049/jimmunol.167.7.3550
[6]  Fock, K.M. (2014) Review Article: The Epidemiology and Prevention of Gastric Cancer. Alimentary Pharmacology & Therapeutics, 40, 250-260.
https://doi.org/10.1111/apt.12814
[7]  Mikuriya, Y., Tashiro, H., Kuroda, S., Nambu, J., Kobayashi, T., Amano, H., Tanaka, Y. and Ohdan, H. (2015) Fatty Liver Creates a Pro-Metastatic Microenvironment for Hepatocellular Carcinoma through Activation of Hepatic Stellate Cells. International Journal of Cancer, 136, E3-E13.
https://doi.org/10.1002/ijc.29096
[8]  Stein, U., Dahlmann, M. and Walther, W. (2010) MACC1-More than Metastasis? Facts and Predictions about a Novel Gene. Journal of Molecular Medicine, 88, 11-18.
https://doi.org/10.1007/s00109-009-0537-1
[9]  Sierra, J.R. and Tsao, M.S. (2011) c-MET as a Potential Therapeutic Target and Biomarker in Cancer. Therapeutic Advances in Medical Oncology, 3, S21-S35.
https://doi.org/10.1177/1758834011422557
[10]  Xie, Q.P., Xiang, C., Wang, G., Lei, K.F. and Wang, Y. (2016) MACC1 Upregulation Promotes Gastric Cancer Tumor Cell Metastasis and Predicts a Poor Prognosis. Journal of Zhejiang University Science B, 17, 361-366.
https://doi.org/10.1631/jzus.B1500236
[11]  Wang, L., Wu, Y., Lin, L., Liu, P., Huang, H., Liao, W., Zheng, D., Zuo, Q., Sun, L., Huang, N., et al. (2013) Metastasis-Associated in Colon Cancer 1 Upregulation Predicts a Poor Prognosis of Gastric Cancer, and Promotes Tumor Cell Proliferation and Invasion. International Journal of Cancer, 133, 1419-1430.
https://doi.org/10.1002/ijc.28140
[12]  Wang, G., Fu, Z. and Li, D. (2015) MACC1 Overexpression and Survival in Solid Tumors: A Meta-Analysis. Tumor Biology, 36, 1055-1065.
https://doi.org/10.1007/s13277-014-2736-9
[13]  Kokoszyńska, K., Kryński, J., Rychlewski, L., et al. (2009) Unexpected Domain Composition of MACC1 Links MET Signaling and Apoptosis. Acta Biochimica Polonica, 56, 317-323.
https://doi.org/10.18388/abp.2009_2464
[14]  Lang, A.H., Geller-Rhomberg, S., Winder, T., et al. (2012) A Common Variant of the MACC1 Gene Is Significantly Associated with Overall Survival in Colorectal Cancer Patients. BMC Cancer, 12, 20.
https://doi.org/10.1186/1471-2407-12-20
[15]  Lee, H.S., Cho, S.B., Lee, H.E., et al. (2007) Protein Expression Profiling and Molecular Classification of Gastric Cancer by the Tissue Array Method. Clinical Cancer Research, 13, 4154-4163.
https://doi.org/10.1158/1078-0432.CCR-07-0173
[16]  Mizokami, K., Kakeji, Y., Oda, S., et al. (2006) Clinicopathologic Significance of Hypoxia-Inducible Factor 1 Alpha Overexpression in Gastric Carcinomas. Journal of Surgical Oncology, 94, 149-154.
https://doi.org/10.1002/jso.20568
[17]  Song, L.B., Liao, W.T., Mai, H.Q., et al. (2006) The Clinical Significance of Twist Expression in Nasopharyngeal Carcinoma. Cancer Letters, 242, 258-265.
https://doi.org/10.1016/j.canlet.2005.11.013
[18]  Kolev, Y., Uetake, H., Iida, S., Ishikawa, T., Kawano, T. and Sugihara, K. (2007) Prognostic Significance of VEGF Expression in Correlation with COX-2, Micro-Vessel Density, and Clinicopathological Characteristics in Human Gastric Carcinoma. Annals of Surgical Oncology, 14, 2738-2747.
https://doi.org/10.1245/s10434-007-9484-7
[19]  Ferlay, J., Soerjomataram, I., Ervik, M., Dikshit, R., Eser, S. and Mathers, C. (2015) Cancer Incidence and Mortality Worldwide. International Journal of Cancer, 136, E359-E386.
https://doi.org/10.1002/ijc.29210
[20]  Xu, Z.Y., Chen, J.S. and Shu, Y.Q. (2010) Gene Expression Profile towards the Prediction of Patient Survival of Gastric Cancer. Biomedicine & Pharmacotherapy, 64, 133-139.
https://doi.org/10.1016/j.biopha.2009.06.021
[21]  Lin, L., Huang, H., Liao, W., Ma, H., Liu, J., Wang, L., Huang, N., Liao, Y. and Liao, W. (2015) MACC1 Supports Human Gastric Cancer Growth under Metabolic Stress by Enhancing the Warburg Effect. Oncogene, 34, 2700-2710.
https://doi.org/10.1038/onc.2014.204
[22]  Sun, L., Duan, J., Jiang, Y., Wang, L., Huang, N., Lin, L., Liao, Y. and Liao, W. (2015) Metastasis-Associated in Colon Cancer-1 Upregulates Vascular Endothelial Growth Factor-C/D to Promote Lymphangiogenesis in Human Gastric Cancer. Cancer Letters, 357, 242-253.
https://doi.org/10.1016/j.canlet.2014.11.035

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