Background:Gastric adenocarcinoma is known to be a markedly
invasivedisease with
high potential formetastasis. Hepatocyte growth factor (HGF)/HGF receptor (MET) signaling
pathway activation is an assumed mechanism of malignant transformation and
metastatic potential of tumors. Metastasisassociated
with colon cancer-1 (MACC-1) has been identified as a key regulator of HGF/MET signaling.However,
its role in gastric cancer is not well understood.Aim of
this studyis to assess the expression of MACC-1 in gastric cancer, its relation to
other clinical and pathologic parameters and its impact on progression free and
overall survival. Patient and
Methods:Evaluation of MACC-1 protein expression by immune-histochemistry
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