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Clinical and Pathological Value of MACC-1 Expression in Gastric Carcinoma

DOI: 10.4236/jct.2019.107050, PP. 609-618

Keywords: Gastric Cancer, MACC-1, HGF/MET Signaling

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Background: Gastric adenocarcinoma is known to be a markedly invasive disease with high potential for metastasis. Hepatocyte growth factor (HGF)/HGF receptor (MET) signaling pathway activation is an assumed mechanism of malignant transformation and metastatic potential of tumors. Metastasis associated with colon cancer-1 (MACC-1) has been identified as a key regulator of HGF/MET signaling. However, its role in gastric cancer is not well understood. Aim of this study is to assess the expression of MACC-1 in gastric cancer, its relation to other clinical and pathologic parameters and its impact on progression free and overall survival. Patient and Methods: Evaluation of MACC-1 protein expression by immune-histochemistry


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