All Title Author
Keywords Abstract

A Rare Case of Synchronous Presentation of Acute Myeloid Leukemia and Lung Cancer

DOI: 10.4236/jct.2019.106039, PP. 471-475

Keywords: Synchronous Malignancy, Lung Cancer, Acute Myeloid Leukemia

Full-Text   Cite this paper   Add to My Lib


Background: There are very few publications on synchronous presentation of dual malignancies in the literature. Occurrence of second malignancy in a patient with a known malignant tumor is not uncommon, though synchronous primary malignancies are unusual. Case Presentation: A 77-year-old man was diagnosed elsewhere as squamous cell carcinoma of lung came to our oncology department for further management. He underwent bone marrow evaluation with the suspicious of metastasis in view of pancytopenia. On bone marrow evaluation, found to have prominence of blasts more than 20%, which were CD34 positive and CD117 positive and. Conclusion: Here we describe an unusual rare combination of synchronous presentation of acute myeloid leukemia and squamous cell carcinoma of lung.


[1]  Braakhuis, B.J., Tabor, M.P., Leemans, C.R., van der Waal, L., Snow, G.B. and Brakenhoff, R.H. (2002) Second Primary Tumors and Field Cancerization in Oral and Oropharyngeal Cancer: Molecular Techniques Provide New Insights and Definitions. Head & Neck, 24, 198-206.
[2]  Chakrabarti, S., Chakrabatri, P.R., Desai, S.M., Agarwal, D., Mehta, D.Y. and Somanath, S. (2015) Spectrum of Second Primary Malignant Neoplasms in Central India: Case Series from a Tertiary Care Centre. The Nigerian Postgraduate Medical Journal, 22, 233-236.
[3]  Curtiz, R.E., Freedom, D.M., Ron, E., Ries, L.A., Hacker, D.G., Edwards, B.K., et al. (2006) New Malignancies among Cancer Survivors: SEER Cancer Registries, 1973-2000. National Cancer Institute.
[4]  Howe, H.L. (2003) A Review of the Definition for Multiple Primary Cancers in the United States. Workshop Proceedings from December 4-6, 2002, in Princeton New Jersey. Springfield, IL.
[5]  Varadarajan, R., Ford, L.A., Sait, S.N.J., Block, A.M.W., Barcos, M., Wallace, P.K., et al. (2009) Metachronous and Synchronous Presentation of Acute Myeloid Leukemia and Lung Cancer. Leukemia Research, 33, 1208-1211.
[6]  Sheridan, W.P., Ellims, P.H., Hancock, W.W. and Forster, D.C. (1984) Simultaneous Occurrence of Acute Myeloid Leukemia and Carcinomatosis. British Journal of Haematology, 58, 199-200.
[7]  Sandler, D.P., Shore, D.L., Anderson, J.R., et al. (1993) Cigarette Smoking and Risk of Acute Leukemia: Associations with Morphology and Cytogenetic Abnormalities in Bone Marrow. Journal of the National Cancer Institute, 85, 1994-2003.
[8]  Lichtman, M.A. (2007) Cigarette Smoking, Cytogenetic Abnormalities, and Acute Myelogenous Leukemia. Leukemia, 21, 1137-1140.
[9]  Hecht, S.S., Abbaspour, A. and Hoffman, D. (1988) A Study of Tobacco Carcinogenesis. XLII. Bioassay in A/J Mice of Some Structural Analogues of Tobacco-Specific Nitrosamines. Cancer Letters, 42, 141-145.
[10]  Snyder, R. (2002) Benzene and Leukemia. Critical Reviews in Toxicology, 32, 155-210.
[11]  Crane, M.M., Strom, S.S., Halabi, S., Berman, E.L., Fueger, J.J., Spitz, M.R., et al. (1996) Correlation between Selected Environmental Exposures and Karyotype in Acute Myelocytic Leukemia. Cancer Epidemiology, Biomarkers & Prevention, 5, 639-644.
[12]  Di Martino, E., Sellhaus, B., Hausmann, R., Minkenberg, R., Lohmann, M. and Esthofen, M.W. (2002) Survival in Second Primary Malignancies of Patients with Head and Neck Cancer. The Journal of Laryngology & Otology, 116, 831-838.
[13]  Agarwal, R. (2007) Synchronous Dual Malignancy; Successfully Treated Cases. Journal of Cancer Research and Therapeutics, 3, 153-156.


comments powered by Disqus

Contact Us


微信:OALib Journal