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Viscoelastic Evaluation of Different Hyaluronic Acid Based Fillers Using Vibrational Optical Coherence Tomography

DOI: 10.4236/msa.2019.105031, PP. 423-431

Keywords: Hyaluronic Acid, Injectable Filler, Dermal Filler, Plastic Surgery, Cosmetic Surgery, Viscoelastic, Mechanical Properties, Facial Surgery, Optical Coherence Tomography, Vibrational Optical Coherence Tomography

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Abstract:

Hylauronic acid (HA) is used as a viscoelastic in Ophthalmology during cataract surgery based on its high viscosity at rest, its ability to shear thin and dissipate energy during phacoemulsification. However, these properties of HA solutions would make them susceptible to migration when used as dermal filler materials. In this study, we apply a new technique termed vibrational optical coherence tomography (VOCT) to compare the physical properties of different HA solutions and fillers used in facial aesthetics. Results presented in this study suggest that HA solutions and HA dermal fillers have markedly different physical properties. HA solutions are highly viscoelastic with high % viscous losses while fillers tend to have lower viscous energy dissipation properties. Clinical observations suggest that the high loss fillers are injected more superficially in the face where tension and internal and external forces are more likely minimized giving tissue of the hands and lips more volume and allowing more natural movement. In contrast, the lower loss gels that are used to lift tissue, generally have a higher G’, and are injected deeper into the face where injection and internal forces are likely to be higher. It is concluded that HA filler gel design can be optimized by use of VOCT to evaluate the % viscous energy loss both in vitro and in vivo.

References

[1]  Dicker, K.T., Gurski, L.A., Pradhan-Bhat, S., Witt, R.L., Farach-Carson, M.C. and Jia, X. (2014) Hyaluronan: A Simple Polysaccharide with Diverse Biological Functions. Acta Biomaterialia, 10, 1558-1570.
https://doi.org/10.1016/j.actbio.2013.12.019
[2]  Silver, F.H. and Benedetto, D. (1996) Polysaccharides Used in Ophthalmology. In: Dumitriu, S., Ed., Polysaccharides Used in Medicinal Applications, Marcel Dekker Inc., New York, 689-703.
[3]  Fallacara, A., Manfredini, S., Durini, E. and Vertuani, S. (2017) Hyaluronic Acid Fillers in Soft Tissue Regeneration. Facial Plastics Surgery, 33, 87-96.
https://doi.org/10.1055/s-0036-1597685
[4]  Greene, J.J. and Sidle, D.M. (2015) The Hyaluronic Acid Fillers Current Understanding of the Tissue Device Interface. Facial Plastic Surgery Clinics of North America, 23, 423-432.
https://doi.org/10.1016/j.fsc.2015.07.002
[5]  Urdiales-Gálvez, F., Escoda Delgado, N., Figueiredo, V., Lajo-Plaza, J.V., Mira, M., Mar Mira, Ortíz-Martí, F., del Rio-Reyes, R., Romero-á lvarez, N., Ruiz del Cueto, S., Martía A. Segurado, M.A. and Villanueva Rebenaque, C. (2017) Preventing the Complications Associated with the Use of Dermal Fillers in Facial Aesthetic Procedures: An Expert Group Consensus Report. Aesthetic Plastic Surgery, 41, 667-677.
https://doi.org/10.1007/s00266-017-0798-y
[6]  Vedamurthy, M. (2018) Beware What You Inject: Complications of Injectables-Dermal Fillers. Journal of Cutaneous and Aesthetic Surgery, 11, 60-66.
https://doi.org/10.4103/JCAS.JCAS_68_18
[7]  Shah, R., DeVore, D. and Pierce, M.G. (2016) Morphomechanics of Dermis: A Method for Non-Destructive Testing and Collagenous Tissues. Skin Research and Technology, 23.
[8]  Shah, R., Pierce, M.C. and Silver, F.H. (2017) A Method for Non-Destructive Mechanical Testing of Tissues and Implants. Journal of Biomedical Materials Research Part A, 105, 5-22.
https://doi.org/10.1002/jbm.a.35859
[9]  Silver, F.H. and Silver, L.L. (2017) Non-Invasive Viscoelastic Behavior of Human Skin and Decellularized Dermis Using Vibrational OCT. Dermatology Clinics & Research, 3, 174-179.
[10]  Shah, R.G., DeVore, D. and Silver, F.H. (2018). Biomechanical Analysis of Decellularized Dermis and Skin: Initial in Vivo Observations Using OCT and Vibrational Analysis. JJournal of Biomedical Materials Research Part A, 106.
https://doi.org/10.1002/jbm.a.36344
[11]  Silver, F.H., DeVore, D. and Shah, R. (2017) Biochemical, Biophysical and Mechanical Characterization of Decellularized Dermal Implants. Material Sciences and Applications, 8, 873-888.
https://doi.org/10.4236/msa.2017.812064
[12]  Silver, F.H. and Shah, R.G. (2018) Mechanical Spectroscopy and Imaging of Skin Components in Vivo: Assignment of the Observed Moduli. Skin Research and Technology, 25.
https://doi.org/10.1111/srt.12594
[13]  Silver, F.H. and Silver, L.L. (2018) Use of Vibrational Optical Coherence Tomography in Dermatology. Archives of Dermatology and Skin Care, 1, 3-8.
[14]  Silver, F.H., Shah, R.G., Benedetto, D., Dulur, A. and Kirn, T. (2019) Virtual Biopsy and Physical Characterization of Tissues, Biofilms, Implants and Viscoelastic Liquids Using Vibrational Optical Coherence Tomography. World Journal Mechanics, 9, 1-6.
https://doi.org/10.4236/wjm.2019.91001

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