Salvia officinalishas been commonly used in
Syria and other Middle East countries in popular medicine for many medical
purposes. One of the strong claims about its properties is the spasmolytic
effect. The aim of this research was to investigate the spasmolytic effect of
ethanolic extract of Salvia officinalisin isolated rabbit ileum preparations. Male rabbits were sacrificed and
portions of ileum were isolated and mounted in Tyrode’s solution. Afterwards, the experiments were performed according to different groups withdifferent spasmogenic agents: the firstgroupwas only with spontaneous contraction, the
second was KCl-induced contractions and the third was Carbachol-induced contractions. The examined extract was added cumulativelyin all previous groups.Verapamil was used as
a reference. The results showed profound relaxing effect ofS.officinalis extract in mentioned
groups, especially in the group ofKCl-induced contraction. These findings suggest that the main mechanism
of the spasmolytic action is related to the
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