Background: Acute graft-versus-host disease (aGVHD) is the most
frequent and severe complication after allogeneic hematopoietic stem cell
transplantation (HSCT). Objective:To determine if a history of prior infection in the allogeneic
HSTC recipient is a risk factor to develop aGVHD. Methods: A
retrospective cohort study based on data collected from the Department
of Hematopoietic Stem Cell Transplantation at the Instituto Nacional de Pediatría
(INP) from January 1998 to December 2016 was performed to identify if prior
infection was a predictive risk factor for aGVHD. Results:27
patients developed aGVHD (36.4%). Median time to aGVHD presentation was 82 days
(9 to 273 days). Most patients developed grade III aGVHD. Following the
multivariate analysis peripheral blood > bone marrow (OR 12.3; p <
0.001), cell dose > 8.3 × 106/kg (OR 7.1; p = 0.05), peripheral
blood (OR: 11.4; p < 0.001), infection 3 months prior to allogeneic
transplant (OR: 4.5; p < 0.03) and CMV infection in the recipient (OR: 4.68;
p < 0.03) were significant. Conclusions: Either bacterial infection or CMV infection
in the recipient was significant risk factor
within the aGVHD recipients; it is important to
consider these factors for patients that are going to receive an allogeneic
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