All Title Author
Keywords Abstract


磁性介孔二氧化硅纳米药物载体的制备及其研究
Study on the Construction of Nanocarriers Based on Mesoporous Silica

DOI: 10.12677/CC.2018.22007, PP. 39-46

Keywords: 药物释放,性介孔材料,癌症治疗
Drug Delivery
, Magnetic Mesoporous Materials, Cancer Therapy

Full-Text   Cite this paper   Add to My Lib

Abstract:

人们正在努力攻克癌症的治愈,努力探索治疗癌症的方法与技术。磁性介孔二氧化硅纳米药物载体的制备给癌症治疗提供了一个新的研究方向。利用共沉淀法制备Fe3O4纳米粒子,用CTAB做模板剂在Fe3O4的表面包裹SiO2,随后在NaCl的乙醇溶液中搅拌去模版基,使Fe3O4外面形成介孔。实验中通过控制包裹时间,改变TEOS的用量,制备成形貌良好的磁性介孔二氧化硅纳米药物载体。最后对Fe3O4@mSiO2进行表面巯基化修饰,使表面巯基化的Fe3O4@mSiO2不仅能通过介孔载药,还能通过化学键载药,提高载体载药率。磁性介孔二氧化硅纳米药物载体的成功制备,为癌症治疗的靶向治疗带来新的研究方向。
Human beings are working hard to conquer the cure of cancer and strive to explore the methods and techniques of treating cancer. The preparation of magnetic mesoporous silica nano-drug carrier provides a new research direction for cancer treatment. Fe3O4 nanoparticles were prepared by solvothermal method. SiO2 was coated on the surface of Fe3O4 with CTAB as template. Then the template was stirred in the ethanol solution of NaCl to form mesopores outside Fe3
References

[1]  Qiu, H.J., Cui, B., Li, G.M., et al. (2014) Novel Fe3O4@ZnO@mSiO2 Nanocarrier for Targeted Drug Delivery and Controllable Release with Microwave Irradiation. The Journal of Physical Chemistry, C. Nanomaterials and Interfaces, 118, 14929-14937.
https://doi.org/10.1021/jp502820r
[2]  Zhao, C.-X., Yu, L., Middelberg, A.P.J., et al. (2013) Magnetic Mesoporous Silica Nanoparticles End-Capped with Hydroxyapatite for pH-Responsive Drug Release. Journal of Materials Chemistry, B. Materials for Biology and Medicine, 1, 4828-4833.
https://doi.org/10.1039/c3tb20641f
[3]  Yang, C.Y., Guo, W., Cui, L.R., et al. (2015) Fe3O4@mSiO2 Core-Shell Nanocomposite Capped with Disulfide Gatekeepers for Enzyme-Sensitive Controlled Release of Anti-Cancer Drugs. Journal of Materials Chemistry, B. Materials for Biology and Medicine, 3, 1010-1019.
https://doi.org/10.1039/C4TB01788A
[4]  Zhang, H., Xue, Y., Huang, J., Xia, X., Song, M., Wen, K., Zhang, X., Luo, X., Cai, N., Long, S. and Yu, F. (2014) Tailor-Made Magnetic Nanocarriers with pH-Induced Charge Reversal and pH-Responsiveness to Guide Subcellular Release of Doxorubicin. Journal of Materials Science, 50, 2429-2442.
https://doi.org/10.1007/s10853-014-8798-7
[5]  Wu, H., Zhu, H., Li, X., Liu, Z., Zheng, W., Chen, T., Yu, B. and Wong, K.-H. (2013) Induction of Apoptosis and Cell Cycle Arrest in A549 Human Lung Adenocarcinoma Cells by Surface-Capping Selenium Nanoparticles: An Effect Enhanced by Polysaccharide-Protein Complexes from Polyporus Rhinocerus. Journal of Agricultural and Food Chemistry, 61, 9859-9866.
https://doi.org/10.1021/jf403564s
[6]  Jiang, D., Huan, Y., Sun, C., Hu, C., Guo, J., Long, J., Khan, M.A., Young, D.P. and Guo, Z. (2016) Thermal, Mechanical and Magnetic Properties of Functionalized Magnetite/Vinyl Ester Nanocomposites. RSC Advances, 6, 91584-91593.
https://doi.org/10.1039/C6RA17190G
[7]  Yantasee, W., Rutledge, R.D., Chouyyok, W., Sukwarotwat, V., Orr, G., Warner, C.L., Warner, M.G., Fryxell, G.E., Wiacek, R.J., Timchalk, C. and Addleman, R.S. (2010) Functionalized Nanoporous Silica for the Removal of Heavy Metals from Biological Systems: Adsorption and Application. ACS Applied Materials & Interfaces, 2, 2749-2758.
https://doi.org/10.1021/am100616b
[8]  Swami, S., Agarwala, A. and Shrivastava, R. (2016) Sulfonic Acid Functionalized Silica-Coated CuFe2O4 Core-Shell Nanoparticles: An Efficient and Magnetically Separable Heterogeneous Catalyst for the Synthesis of 2-Pyrazole-3-Amino-Imidazo-Fused Polyheterocycles. New Journal of Chemistry, 40, 9788-9794.
https://doi.org/10.1039/C6NJ02264B
[9]  Bakhshaei, S., Kamboh, M.A., Nodeh, H.R., Md Zain, S., Mahmad Rozi, S.K., Mohamad, S. and Mohammed Mohialdeen, I.A. (2016) Magnetic Solid Phase Extraction of Polycyclic Aromatic Hydrocarbons and Chlorophenols Based on Cyano-Ionic Liquid Functionalized Magnetic Nanoparticles and Their Determination by HPLC-DAD. RSC Advances, 6, 77047-77058.
https://doi.org/10.1039/C6RA13702D
[10]  Zhang, H., Zhang, Y., Zhou, Y., Zhang, C., Wang, Q., Xu, Y. and Zhang, M. (2016) Synthesis and Characterization of a Multifunctional Nanocatalyst Based on a Novel Type of Bina-ry-Metal-Oxide-Coated Fe3O4-Au Nanoparticle. RSC Advances, 6, 18685-18694.
https://doi.org/10.1039/C5RA27136C

Full-Text

comments powered by Disqus