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Nutritional Quality and Effect on Disease Prevention of Vegetables

DOI: 10.4236/fns.2019.104029, PP. 369-402

Keywords: Vegetables, Health Benefits, Healthier Life, Nutrition, ANDI, Bioactive Compounds, Antioxidants, Dietary Fiber, Vitamins, Minerals, Phytochemicals

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Abstract:

Vegetables have remarkable nutritional and health benefits. There are good reasons to include vegetables in human diet since they are enriched in bioactive compounds and by this reason they may help reduce the risk of some diseases. In this paper it was analyzed the nutrition quality and effect on disease prevention of vegetables. Each vegetable family and each vegetable contain a unique combination of bioactive compounds. The health benefit of vegetables should not be linked to one type of vegetable. It is presented some experimental research evidences that vegetables exert anti-oxidative, anti-carcinogenic, anti-diabetic and cardiovascular disease lowering effects. The mechanism by which vegetable bioactive compounds decrease the risk of some of these diseases is complex and sometimes unknown.

References

[1]  Dias, J.S. and Ryder, E. (2011) World Vegetable Industry: Production, Breeding, Trends. Horticultural Reviews, 38, 299-356.
[2]  Dias, J.S. (2012) Major Classes of Phytonutriceuticals in Vegetables and Health Benefits: A Review. Journal of Nutritional Therapeutics, 1, 31-62.
https://doi.org/10.6000/1929-5634.2012.01.01.5
[3]  Dias, J.S. (2012) Vegetable Breeding for Nutritional Quality and Health Benefits. In: Carbone, K., Ed., Cultivar: Chemical Properties, Antioxidant Activities and Health Benefits, Nova Science Publishers Inc., New York, 1-81.
https://doi.org/10.4236/fns.2012.39159
[4]  Prior, R.L. and Cao, G. (2000) Antioxidant Phytochemicals in Fruit and Vegetables, Diet and Health Implications. HortScience, 35, 588-592.
https://doi.org/10.21273/HORTSCI.35.4.588
[5]  Hyson, D. (2002) The Health Benefits of Fruit and Vegetables. A Scientific Overview for Health Professionals. Produce for Better Health Foundation, Wilmington DE.
[6]  Golberg, G. (2003) Plants: Diet and Health. The Report of a British Nutrition Foundation Task Force. Blackwell Science, Oxford.
https://doi.org/10.1002/9780470774465
[7]  International Fruit and Vegetable Alliance (IFAVA) (2006) Fruit, Vegetables and Health: A Scientific Overview. International Fruit and Vegetable Alliance, Ottawa, Canada.
[8]  Malaterreb, A.S., Remizeb, F. and Pouchereta, P. (2018) Fruits and Vegetables, as a Source of Nutritional Compounds and Phytochemicals. Changes in Bioactive Compounds during Lactic Fermentation. Food Research International, 104, 86-99.
https://doi.org/10.1016/j.foodres.2017.09.031
[9]  Saura-Calixto, F. and Goni, I. (2006) Antioxidant Capacity of the Spanish Mediterranean Diet. Food Chemistry, 94, 442-447.
https://doi.org/10.1016/j.foodchem.2004.11.033
[10]  Saura-Calixto, F., Serrano, J. and Goni, I. (2007) Intake and Bioaccessibility of Total Polyphenols in a Whole Diet. Food Chemistry, 101, 492-501.
https://doi.org/10.1016/j.foodchem.2006.02.006
[11]  Kays, S.J. and Dias, J.S. (1995) Common Names of Commercially Cultivated Vegetables of the World in 15 Languages. Economic Botany, 49, 115-152.
https://doi.org/10.1007/BF02862917
[12]  Kays, S.J. (2011) Cultivated Vegetables of the World: A Multilingual Onomasticon. Wageningen Academic Publishers, Netherlands.
https://doi.org/10.3920/978-90-8686-720-2
[13]  Dias, J.S. (2014) Major Classes of Phytonutriceuticals in Vegetables and Health Benefits: A Review. In: Nath, P., Ed., The Basics of Human Civilization-Food, Agriculture and Humanity, Volume-II-Food, Prem Nath Agricultural Science Foundation (PNASF), Bangalore & New India Publishing Agency (NIPA), New Delhi, India, 305-370.
[14]  Nielsen, S.E., Young, J.F., Daneshvar, B., Lauriden, S.T., Knuthsen, P., Sandrstromand, B. and Dragsted, L.O. (1999) Effect of Parsley (Petroselinum crispum) Intake on Urinary Apigenin Excretion, Blood Antioxidant Enzymes and Biomarkers for Oxidative Stress in Human Subjects. British Journal of Nutrition, 81, 447-455.
https://doi.org/10.1017/S000711459900080X
[15]  Horbowicz, M., Kosson, R., Grzesiuk, A. and Bski, H.D. (2008) Anthocyanins of Fruits and Vegetables: Their Occurrence Analysis and Role in Human Nutrition. Vegetable Crops Research Bulletin, 68, 5-22.
https://doi.org/10.2478/v10032-008-0001-8
[16]  Lila, M.A. (2004) Anthocyanins and Human Health: An in Vitro Investigative Approach. Journal of Biomedicine and Biotechnology, 5, 306-313.
https://doi.org/10.1155/S111072430440401X
[17]  Ching, L.S. and Mohamed, S. (2001) Alpha-Tocopherol Content of 62 Edible Tropical Plants. Journal of Agricultural and Food Chemistry, 49, 3101-3105.
https://doi.org/10.1021/jf000891u
[18]  Crozier, A., Burns, J., Aziz, A.A, Stewart, A.J., Rabiasz, H.S., Jenkins, G.I., Edwards, C.A. and Lean, M.E.J. (2000) Antioxidant Flavonols from Fruits, Vegetables and Beverages: Measurements and Bioavailability. Biological Research, 33, 79-88.
https://doi.org/10.4067/S0716-97602000000200007
[19]  Prakash, D., Nath, P. and Pal, M. (1993) Composition, Variation of Nutritional Contents in Leaves, Seed Protein, Fat and Fatty Acid Profile of Chenopodium species. Journal of the Science of Food and Agriculture, 62, 203-205.
https://doi.org/10.1002/jsfa.2740620214
[20]  Sienera, R. (2006) Oxalate Contents of Species of the Polygonaceae, Amaranthaceae and Chenopodiaceae Families. Food Chemistry, 98, 220-224.
https://doi.org/10.1016/j.foodchem.2005.05.059
[21]  Dhillon, N.P.S., Monforte, A.J. and Pitrat, M. (2012) Melon Landraces of India: Contributions and Importance. Plant Breeding Reviews, 35, 85-150.
[22]  Burger, Y., Yeselson, Y., Saar, U., Paris, H.S., Katzir, N., Tadmor, Y. and Schaffer, A.A. (2004) Screening of Melon (Cucumis melo) Germplasm for Consistently High Sucrose Content and for High Ascorbic Acid Content. In: Lebeda, A. and Paris, H.S., Eds., Progress in Cucurbit Genetics and Breeding Research, Palacky University, Olomouc, Czech Republic, 151-155.
[23]  Crosby, K.M., Lester, G.E. and Leskovar, D.I. (2006) Genetic Variation for Beneficial Phytochemical Levels in Melons (Cucumis melo) In: Holmes, G.J., Ed., Cucurbitaceae 2006, Universal Press, Raleigh, NC, 70-76.
[24]  Misra, S.K. (2012) Anti-Nutritive Bioactive Compounds Present in Unconventional Pulses and Legumes. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 3, 586-597.
[25]  Mallillin, A.C., Trinidad, T.P., Raterta, R., Dagbay, K. and Loyola, A.S. (2008) Dietary Fiber and Fermentability Characteristics of Root Crops and Legumes. British Journal of Nutrition, 100, 485-488.
https://doi.org/10.1017/S000711450891151X
[26]  Trinidad, T.P., Mallillin, A.C., Loyola, A.S., Sagum, R.S. and Encabo, R.R. (2010) The Potential Health Benefits of Legumes as a Good Source of Dietary Fiber. British Journal of Nutrition, 103, 569-574.
https://doi.org/10.1017/S0007114509992157
[27]  Dias, J.S. (2011) World Importance, Marketing and Trading of Vegetables. Acta Horticulturae, 921, 153-169.
https://doi.org/10.17660/ActaHortic.2011.921.18
[28]  Fahey, J.W., Zalcmann, A.T. and Talalay, P. (2001) The Chemical Diversity and Distribution of Glucosinolates and Isothiocyanates among Plants. Phytochemistry, 56, 5-51.
https://doi.org/10.1016/S0031-9422(00)00316-2
[29]  VanEtten, C.H., Dzenbichler, M.E., Williams, P. and Kwolek, W.F. (1976) Glucosinolates and Derived Products in Cruciferous Vegetables. Analysis in the Edible Part from Twenty-Two Varieties of Cabbage. Journal of Agricultural and Food Chemistry, 24, 452-455.
https://doi.org/10.1021/jf60205a049
[30]  Carlson, D.G., Daxenbichler, M.E., Van Etten, C.H., Tookey, H.L. and Williams, P.H. (1981) Glucosinolates in Crucifer Vegetables: Turnip and Rutabagas. Journal of Agricultural and Food Chemistry, 29, 1235-1239.
https://doi.org/10.1021/jf00108a034
[31]  Carlson, D.G., Daxenbichler, M.E., VanEtten, C.H., Hill, C.B. and Williams, P.H. (1985) Glucosinolates in Radish Cultivars. Journal of the American Society for Horticultural Science, 110, 634-638.
[32]  Carlson, D.G., Daxenbichler, M.E., VanEtten, C.H., Hill, C.B. and Williams, P.H. (1987) Glucosinolates in Crucifer Vegetables: Broccoli, Brussels Sprouts, Cauliflower, Collards, Kale, Mustard Green, and Kohlrabi. Journal of the American Society for Horticultural Science, 112, 173-178.
[33]  Carlson, D.G., Daxenbichler, M.E., VanEtten, C.H., Hill, C.B. and Williams, P.H. (1987) Glucosinolates in Turnip Tops and Roots: Cultivars Grown for Greens and/or Roots. Journal of the American Society for Horticultural Science, 112, 179-183.
[34]  Kushad, M.K., Brown, A.F., Kurillicn, A.C., Juvik, J.A., Klein, B.P., Wallig, M.A. and Jeffery, E.H. (1999) Variation in Glucosinolates in Vegetable Crops of Brassica oleracea. Journal of Agricultural and Food Chemistry, 47, 1541-1548.
https://doi.org/10.1021/jf980985s
[35]  Ciska, E., Martyniak-Przybyszewska, B. and Kozlowska, H. (2000) Content of Glucosinolates in Cruciferous Vegetables Grown at the Same Site for Two Years under Different Climatic Condition. Journal of Agricultural and Food Chemistry, 48, 2862-2867.
https://doi.org/10.1021/jf981373a
[36]  Vallejo, F., Tomas-Barberan, F.A., Banavent-Garcia, A.G. and Garcia-Viguera, C. (2003) Total and Individual Glucosinolate Contents in Inflorescences of Eight Broccoli Cultivars Grown under Various Climatic and Fertilization Conditions. Journal of the Science of Food and Agriculture, 83, 307-313.
https://doi.org/10.1002/jsfa.1320
[37]  Nilsson, J., Olsson, K., Engqvist, G., Ekvall, J., Olsson, M., Nyman, M. and Akesson, B. (2006) Variation in the Content of Glucosinolates, Hydroxycinnamic Acids, Carotenoids, Total Antioxidant Capacity and Low-Molecular-Weight Carbohydrates in Brassica Vegetables. Journal of the Science of Food and Agriculture, 86, 528-538.
https://doi.org/10.1002/jsfa.2355
[38]  Borkowski, J., Szajdek, A., Borkowska, E.J., Ciska, E. and Zielinski, H. (2008) Content of Selected Bioactive Components and Anti Oxidant Properties of Broccoli (Brassica oleracea L.). European Food Research and Technology, 226, 459-465.
https://doi.org/10.1007/s00217-006-0557-9
[39]  Cartea, M.E., Velasco, P., Obregón, S., Padilla, G. and de Haro, A. (2008) Seasonal Variation in Glucosinolate Content in Brassica oleracea Crops Grown in Northwestern Spain. Phytochemistry, 69, 403-410.
https://doi.org/10.1016/j.phytochem.2007.08.014
[40]  Hansen, M., Bengtsson, G.B., Borge, G.I., Berge, L. and Wold, A.B. (2010) Red Cabbage, a Vegetable Rich in Health-Related Glucosinolates. Acta Horticulturae, 867, 61-65.
https://doi.org/10.17660/ActaHortic.2010.867.6
[41]  Fahey, J.W., Zhang, Y.S. and Talalay, P. (1997) Broccoli Sprouts: An Exceptionally Rich Source of Inducers of Enzymes That Protects against Chemical Carcinogens. Proceedings of the National Academy of Sciences of the United States of America, 94, 10367-10372.
https://doi.org/10.1073/pnas.94.19.10367
[42]  Goodrich, R.M., Anderson, J.L. and Stoewsand, G. (1989) Glucosinolate Changes in Blanched Broccoli and Brussels Sprouts. Journal of Food Processing and Preservation, 13, 275-280.
https://doi.org/10.1111/j.1745-4549.1989.tb00106.x
[43]  Vallejo, F., Tomas-Barberan, F.A. and Garcia-Viguera, C. (2002) Potential Bioactive Compounds in Health Promotion from Broccoli Cultivars Grown in Spain. Journal of the Science of Food and Agriculture, 82, 1293-1297.
https://doi.org/10.1002/jsfa.1183
[44]  Kusznierewics, B., Bartoszek, A., Wolska, L., Drzewiwcki, J., Gorinstein, S. and Namiesnik, J. (2008) Partial Characterization of White Cabbages (Brassica oleracea var. capitata f. alba) from Different Regions by Glucosinolates, Bioactive Compounds, Total Antioxidant Activities and Proteins. LWT, 41, 1-9.
https://doi.org/10.1016/j.lwt.2007.02.007
[45]  Cao, G., Sofic, E. and Prior, R.L. (1996) Antioxidant Capacity of Tea and Common Vegetables. Journal of Agricultural and Food Chemistry, 4, 3426-3431.
https://doi.org/10.1021/jf9602535
[46]  Scott, J., Releille, F. and Fletcher, J. (2000) Folic Acid and Folates: The Feasibility for Nutricional Enhancement in Plant Foods. Journal of the Science of Food and Agriculture, 80, 795-824.
https://doi.org/10.1002/(SICI)1097-0010(20000515)80:7<795::AID-JSFA599>3.0.CO;2-K
[47]  Konings, E.J.M., Roomans, H.H., Dorant, E., Goldbohm, R.A., Saris, W.H. and van den Brandt, P.A. (2001) Folate Intake of the Dutch Population According to Newly Established Liquid Chromatography Data for Foods. American Journal of Clinical, 73, 765-776.
https://doi.org/10.1093/ajcn/73.4.765
[48]  Banuelos, G. and Meek, D. (1989) Selenium Accumulation in Selected Vegetables. Journal of Plant Nutrition, 12, 1255-1272.
https://doi.org/10.1080/01904168909364034
[49]  Nencini, C., Cavallo, F., Capasso, A., Franchi, G.G., Giorgio, G. and Micheli, L. (2007) Evaluation of Antioxidative Properties of Allium Species Growing Wild in Italy. Phytotherapy Research, 21, 874-878.
https://doi.org/10.1002/ptr.2168
[50]  Kalra, N., Arora, A. and Shukla, Y. (2006) Involvement of Multiple Signaling Pathways in Diallyl Sulfide Mediated Apoptosis in Mouse Skin Tumors. Asian Pacific Journal of Cancer Prevention, 7, 556-562.
[51]  Rose, P., Whiterman, M., Moore, P.K. and Zhu, Y.Z. (2005) Bioactive S-alk(en)yl Cysteine Sulfoxide Metabolites in the Genus Allium: The Chemistry of Potential Therapeutic Agents. Natural Product Reports, 22, 351-368.
https://doi.org/10.1039/b417639c
[52]  Rubec, R., Svobodovaand, M. and Velisek, J. (1999) Gas Chromatographic Determination of S-alk(en)yl-L-Cysteine Sulfoxides. Journal of Chromatography, 862, 85-94.
https://doi.org/10.1016/S0021-9673(99)00902-4
[53]  Thomas, D.J. and Parkin, K.L. (1994) Quantification of Alk(en)yl-L-Cysteine Sulfoxide and Related Amino Acids in Alliums by High-Performance Liquid Chromatography. Journal of Agricultural and Food Chemistry, 42, 1632-1638.
https://doi.org/10.1021/jf00044a010
[54]  Yoo, K.S. and Pike, L.M. (1998) Determination of Flavor Precursor Compound S-alk(en)yl-L-Cysteine Sulfoxides by HPLC Method and Their Distribution in Allium Species. Scientia Horticulturae, 75, 1-10.
https://doi.org/10.1016/S0304-4238(98)00107-1
[55]  Kubec, R., Svobodova, M. and Velisek, J. (1999) Gas-Chromatographic Determination of S-alk(eny)lylcysteine Sulfoxide. Journal of Chromatography, 862, 85-94.
https://doi.org/10.1016/S0021-9673(99)00902-4
[56]  Miean, K.H. and Mohamed, S. (2001) Flavonoid (Myricetin, Quercetin, Kaempferol, Luteolinand Apigenin) Content of Edible Tropical Plants. Journal of Agricultural and Food Chemistry, 49, 106-112.
https://doi.org/10.1021/jf000892m
[57]  Hertog, M.G., Hollman, P.C. and Katan, M.B. (1992) Content of Potentially Anticarcinogenic Flavonoids of 28 Vegetables and Fruits Commonly Consumed in the Netherlands. Journal of Agricultural and Food Chemistry, 40, 2379-2383.
https://doi.org/10.1021/jf00024a011
[58]  Bilyk, A. and Sapers, G.M. (1985) Distribution of Quercetin and Kaemperol in Lettuce, Kale, Chive, Garlic Chive Leek, Horseradish, Red Radish and Red Cabbage Tissue. Journal of Agricultural and Food Chemistry, 33, 226-228.
https://doi.org/10.1021/jf00062a017
[59]  Ip, C. and Lisk, D.J. (1994) Enrichment of Selenium in Allium Vegetables for Cancer Prevention. Carcinogenesis, 15, 1881-1885.
https://doi.org/10.1093/carcin/15.9.1881
[60]  Clinton, S. (1998) Lycopene: Chemistry, Biology and Implication for Human Health and Disease. Nutrition Reviews, 56, 35-51.
https://doi.org/10.1111/j.1753-4887.1998.tb01691.x
[61]  Scott, K.J. and Hart, D.J. (1995) Development and Evolution of an HPLC Method for the Analysis of Carotenoids Food and the Measurement of the Carotenoid Content Vegetables and Fruits Commonly Consumed in the UK. Food Chemistry, 54, 101-111.
https://doi.org/10.1016/0308-8146(95)92669-B
[62]  Tonucci, L.H., Holden, J.M., Beecher, G.R., Khachik, F., Davis, C.S. and Mulokozi, G. (1995) Carotenoid Content of Thermally Processed Tomato-Based Food Products. Journal of Agricultural and Food Chemistry, 43, 579-586.
https://doi.org/10.1021/jf00051a005
[63]  Gerster, H. (1997) The Potential Role of Lycopene for Human Health. Journal of the American College of Nutrition, 16, 109-126.
https://doi.org/10.1080/07315724.1997.10718661
[64]  Agarwal, S. and Rao, A.K. (2000) Tomato Lycopene and Its Role in Human Health and Chronic Diseases. Canadian Medical Association Journal, 163, 739-744.
[65]  Rao, A.V. (2006) Tomatoes, Lycopene and Human Health Preventing Chronic Diseases. Caledonian Science Press, Stranraer, Scotland.
[66]  Leonardi, C., Ambrosino, P., Esposito, F. and Fogliano, V. (2000) Antioxidant Activity and Caroteoid and Tomatine Contentes in Diferent Typologies of Fresh Consumption Tomatoes. Journal of Agricultural and Food Chemistry, 48, 4723-4727.
https://doi.org/10.1021/jf000225t
[67]  Arab, L. and Steck, S. (2000) Lycopene and Cardiovascular Disease. American Journal of Clinical Nutrition, 71, 1691S-1695S.
https://doi.org/10.1093/ajcn/71.6.1691S
[68]  Rao, A.V. and Rao, L.G. (2007) Carotenoids and Human Health. Pharmacological Research, 55, 207-216.
https://doi.org/10.1016/j.phrs.2007.01.012
[69]  Albushita, A.A., Daood, H.G. and Biacs, P.A. (2000) Change in Carotenoids and Antioxidant Vitamins in Tomato as a Function of Varietal and Technological Factors. Journal of Agricultural and Food Chemistry, 48, 2075-2081.
https://doi.org/10.1021/jf990715p
[70]  Albushita, A.A., Hebshi, E.A., Daood, H.G. and Biacs, P.A. (1997) Determination of Antioxidant Vitamins in Tomato. Food Chemistry, 60, 207-212.
https://doi.org/10.1016/S0308-8146(96)00321-4
[71]  Crozier, A., Lean, M.E., McDonaldand, M.S. and Black, C. (1997) Quantitative Analysis of the Flavonoid Content of Commercial Tomatoes, Onions, Lettuce and Celery. Journal of Agricultural and Food Chemistry, 45, 590-595.
https://doi.org/10.1021/jf960339y
[72]  Stewart, A.J. and Bozonnet, S. (2000) Mullen W. Jenkins GI, Lean ME, Crozier A. Occurrence of Flavonols in Tomatoes and Tomato-Based Products. Journal of Agricultural and Food Chemistry, 48, 2663-2669.
https://doi.org/10.1021/jf000070p
[73]  Craig, W. and Beck, L. (1999) Phytochemicals: Health Protective Effects. Canadian Journal of Dietetic Practice and Research, 60, 78-84.
[74]  Dias, J.S. (2012) Nutritional Quality and Health Benefits of Vegetables: A Review. Food and Nutrition Research, 3, 1354-1347.
https://doi.org/10.4236/fns.2012.310179
[75]  Bosland, P.W. (1996) Capsicums: Innovative Uses of an Ancient Crop. In: Janick, J., Ed., Progress in New Crops, ASHS Press, Arlington, VA, 479-487.
[76]  Howard, L.R., Talcott, S.T., Brenes, C.H. and Villalon, B. (2000) Changes in Phytochemical and Antioxidant Activity of Selected Pepper Cultivars (Capsicum species) as Influenced by Maturity. Journal of Agricultural and Food Chemistry, 48, 1713-1720.
https://doi.org/10.1021/jf990916t
[77]  Howard, L.R., Smith, R.T., Wagner, A.B., Villalon, B. and Burns, E.E. (1994) Provitamin A and Ascorbic Acid Content of Fresh Pepper Cultivars (Capsicum annum) and Processed Jalapenos. Journal of Food Science, 59, 362-365.
https://doi.org/10.1111/j.1365-2621.1994.tb06967.x
[78]  Lee, Y., Howard, R. and Villalon, B. (1995) Flavonoids and Antioxidant Activity of Fresh Pepper (Capsicum annum) Cultivars. Journal of Food Science, 60, 473-476.
https://doi.org/10.1111/j.1365-2621.1995.tb09806.x
[79]  Suzuki, T. and Iwai, K. (1984) The Alkaloids. In: Brossi, A., Ed., The Alkaloids Chemistry and Pharmacology, Vol. 13, Academic Press, San Diego, CA, 227-229.
[80]  Thomas, B.V., Schreilber, A.A. and Weisskopf, C.P. (1998) Simple Method for Quantitation of Capsaicinoids in Pepper Using Capillary Gas Chromatography. Journal of Agricultural and Food Chemistry, 46, 2655-2663.
https://doi.org/10.1021/jf970695w
[81]  Frei, B. and Lawson, S. (2008) Vitamin C and Cancer Revisited. Proceedings of the National Academy of Sciences of the United States of America, 105, 11037-11038.
https://doi.org/10.1073/pnas.0806433105
[82]  Noda, Y., Kaneyuki, T., Igarashi, K., Moriand, A. and Pacer, L. (1998) Antioxidant Activity of Nasunin, an Anthocyanin in Eggplant. Research Communications in Chemical Pathology and Pharmacology, 102, 175-187.
[83]  Kayamori, F. and Igarashi, K. (1994) Effect of Dietary Nasunin on the Serum Cholesterol Level in Rats. Bioscience, Biotechnology, and Biochemistry, 58, 570-571.
https://doi.org/10.1271/bbb.58.570
[84]  Noda, Y., Kneyuki, T. and Igarashi, K. (2000) Antioxidant Activity of Nasunin, an Anthocyanin in Eggplant Peels. Toxicology, 148, 119-123.
https://doi.org/10.1016/S0300-483X(00)00202-X
[85]  Matsuzoe, N., Yamaguchi, M., Kawanobu, S., Watanabe, Y., Higashi, H. and Sakata, Y. (1999) Effect of Dark Treatment of the Eggplant on Fruit Skin Color and Its Anthocyanin Components. Journal of the Japanese Society for Horticultural Science, 68, 138-145.
https://doi.org/10.2503/jjshs.68.138
[86]  Whitaker, B.D. and Stommel, J.R. (2003) Distribution of Hydroxycinnamic Acid Conjugates in Fruit of Commercial Eggplant (Solanum melongena L.) Cultivars. Journal of Agricultural and Food Chemistry, 51, 3448-3454.
https://doi.org/10.1021/jf026250b
[87]  Ben-Amos, A. and Fishler, R. (1998) Analysis of Carotenoids with Emphasis on 9-cis β-Carotene in Vegetables and Fruits Commonly Consumed in Israel. Food Chemistry, 62, 515-520.
https://doi.org/10.1016/S0308-8146(97)00196-9
[88]  Assimos, D.G. and Holmes, R.P. (2000) Role of Diet in the Therapy of Urolithiasis. Urologic Clinics of North America, 27, 255-268.
https://doi.org/10.1016/S0094-0143(05)70255-X
[89]  Britton, G. and Khachik, F. (2009) Carotenoids in Food. In: Britton, G., Pfander, H. and Liaaen-Jensens, S., Eds., Carotenoids, Birkhquser, Basel, 45-66.
https://doi.org/10.1007/978-3-7643-7501-0_3
[90]  Fuhrman, J. (2013) The End of Diabetes: The Eat to Live Plan to Prevent and Reverse Diabetes. Harper Collins Publishers, New York.
[91]  Pyo, Y.H., Lee, T.C., Logendrac, L. and Rosen, R.T. (2004) Antioxidant Activity and Phenolic Compounds of Swiss Chard (Beta vulgaris Subspecies cycla) Extracts. Food Chemistry, 85, 19-26.
https://doi.org/10.1016/S0308-8146(03)00294-2
[92]  Bolkent, S., Yanarda, R., Tabakolu-Oguz, A. and Ozsoy-Sacan, O. (2000) Effects of Chard (Beta vulgaris L. var. cicla) Extract on Pancreatic β Cells in Streptozotocin-Diabetic Rats: A Morphological and Biochemical Study. Journal of Ethnopharmacology, 73, 251-259.
https://doi.org/10.1016/S0378-8741(00)00328-7
[93]  Mateljan, G. (2016) The World’s Healthiest Foods. George Mateljan Foundation. Glendale, California.
[94]  Kugler, F., Stintzing, F.C. and Carle, R. (2004) Identification of Betalains from Petioles of Differently Colored Swiss chard (Beta vulgaris L. ssp. cicla [L.] Alef. cv. Bright Lights) by High-Performance Liquid Chromatography-Electrospray Ion. Journal of Agricultural and Food Chemistry, 52, 2975-2981.
https://doi.org/10.1021/jf035491w
[95]  Dias, J.S. and Imai, S. (2017) Vegetables Consumption and Its Benefits on Diabetes. Journal of Nutritional Therapeutics, 6, 1-10.
https://doi.org/10.6000/1929-5634.2017.06.01.1
[96]  Poudyal, H., Panchal, S. and Brown, L. (2010) Comparison of Purple Carrot Juice and β-Carotene in a High-Carbohydrate, High-Fat Diet-Fed Rat Model of the Metabolic Syndrome. British Journal of Nutrition, 104, 1322-1332.
https://doi.org/10.1017/S0007114510002308
[97]  Dias, J.S. (2014) Nutritional and Health Benefits of Carrots and Their Seed Extracts. Food and Nutrition Research, 5, 2147-2156.
https://doi.org/10.4236/fns.2014.522227
[98]  Ferracane, R., Pellegrini, N., Visconti, A., Graziani, G., Chiavaro, E., Miglio, C. and Fogliano, V. (2008) Effects of Different Cooking Methods on Antioxidant Profile, Antioxidant Capacity, and Physical Characteristics of Artichoke. Journal of Agricultural and Food Chemistry, 56, 8601-8608.
https://doi.org/10.1021/jf800408w
[99]  World Health Organization (WHO) (2018) Increasing Fruit and Vegetable Consumption to Reduce the Risk of Non-Communicable Diseases. World Health Organization, E-Library of Evidence for Nutrition Actions (eLENA) World Health Organization, Geneva, Switzerland.
[100]  Fergunson, L.R. (1999) Prospect of Cancer Prevention. Mutation Research, 428, 329-338.
https://doi.org/10.1016/S1383-5742(99)00058-7
[101]  American Institute of Cancer Research (AICR) (2007) Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective. AIRC/World Cancer Research Fund, Washington DC.
[102]  Potter, J.D., Slattery, M.L. and Bostick, R.M. (1993) Colon Cancer: A Review of the Epidemiology. Epidemiologic Reviews, 15, 499-545.
https://doi.org/10.1093/oxfordjournals.epirev.a036132
[103]  Van Duijnhoven, F.J., Bueno-de-Mesquita, H.B., Ferrari, P., Jenab, M., Boshuizen, H.C., Ros, M.M., Casagrande, C., Tjonneland, A., Olsen, A. and Overvad, K. (2009) Fruit, Vegetables and Colorectal Cancer Risk: The European Prospective Investigation into Cancer and Nutrition. American Journal of Clinical Nutrition, 89, 1441-1452.
https://doi.org/10.3945/ajcn.2008.27120
[104]  Trock, B., Lanza, E. and Greenwald, P. (1990) Dietary Fiber, Vegetables, and Colon cancer: Critical Review and Meta-Analysis of the Epidemiologic Evidence. Journal of the National Cancer Institute, 82, 650-661.
https://doi.org/10.1093/jnci/82.8.650
[105]  Neugut, A.I., Jacobson, J.S. and DeVivo, L. (1993) Epidemiology of Colorectal Adenomas: Macronutrients, Cholesterol and Fiber. Journal of the National Cancer Institute, 85, 884-891.
https://doi.org/10.1093/jnci/85.11.884
[106]  Steinmetz, K.A., Kushi, L.H., Bostick, R., Folisom, A.R. and Potter, J.D. (1994) Vegetable, Fruit and Colon Cancer in the Iowa Women’s Health Study. American Journal of Epidemiology, 139, 1-15.
https://doi.org/10.1093/oxfordjournals.aje.a116921
[107]  Witte, J.S., Longnecker, M.P., Bird, S.L., Lee, E.R., Frakl, H.D. and Haile, R.W. (1996) Relation of Vegetable, Fruit and Grain Consumption to Colorectal Adenomatous Polyps. American Journal of Epidemiology, 144, 1015-1025.
https://doi.org/10.1093/oxfordjournals.aje.a008872
[108]  Iscovich, J.M., L’Abbe, K.A., Castelleto, R., Calzona, A., Bernaedo, A., Chopita, N.A., Jmelnitzsky, A.C. and Kaldor, J. (1992) Colon Cancer in Argentina. Risk from Intake of Dietary Items. International Journal of Cancer, 51, 851-857.
https://doi.org/10.1002/ijc.2910510603
[109]  Zaridize, D., Filipchenco, V. and Kustov, V. (1993) Diet and Colorectal Cancer: Results of Two Case-Control Studies in Russia. European Journal of Cancer, 29, 113-115.
https://doi.org/10.1016/0959-8049(93)90586-5
[110]  Tanaka, S., Haruma, K., Yoshihara, M., Kajiyama, G., Kira, K., Amagase, H. and Chayama, K. (2006) Aged Garlic Extract Has Potential Suppressive Effect on Colorectal Adenomas in Humans. Journal of Nutrition, 136, 821S-826S.
https://doi.org/10.1093/jn/136.3.821S
[111]  Radhika, G., Sudha, V., Sathya, R.M., Ganesan, A. and Mohan, V. (2008) Association of Fruit and Vegetable Intake with Cardiovascular Risk Factors in Urban South Indians. British Journal of Nutrition, 99, 398-405.
https://doi.org/10.1017/S0007114507803965
[112]  Soh, Y., Shin, M., Lee, J., Jang, J., Kim, O.H., Kang, H. and Surh, Y. (2003) Oxidative DNA Damage and Glioma Cell Death Induced by Tetrahydropapaveroline. Mutation Research, 544, 129-142.
https://doi.org/10.1016/j.mrrev.2003.06.023
[113]  Tao, J., Li, Y., Li, S. and Li, H.B. (2018) Plant Foods for the Prevention and Management of Colon Cancer. Journal of Functional Foods, 42, 95-110.
https://doi.org/10.1016/j.jff.2017.12.064
[114]  Tewani, R., Sharma, J.K. and Rao, S.V. (2016) Spinach (Palak) Natural Laxative. International Journal of Applied Research and Technology, 1, 140-148.
[115]  Verhoeven, D.T.H., Goldbohm, R.A., van Poppel, G., Verhagen, H. and van den Brandt, P.A. (1996) Epidemiological Studies on Brassica Vegetables and Cancer Risk. Cancer Epidemiology Biomarkers & Prevention, 5, 733-751.
[116]  Ambrosone, C.B., McCann, S.E., Freudenheim, J.L., Marshall, J.R., Zhang, Y. and Shields, P.G. (2004) Breast Cancer Risk in Premenopausal Women Is Inversely Associated with Consumption of Broccoli, a Source of Isothiocyanates, but Is Not Modified by GST Genotype. Journal of Nutrition, 134, 1134-1138.
https://doi.org/10.1093/jn/134.5.1134
[117]  Brennan, P., Hsu, C.C., Moullan, N., Szeszenia-Dabrowska, N., Lissowska, J., Zaridze, D., Rudnai, P., Fabianova, E., Mates, D. and Benckoet, V. (2005) Effect of Cruciferous Vegetables on Lung Cancer in Patients Stratified by Genetic Status: A Mendelian Randomisation Approach. The Lancet, 366, 1558-1560.
https://doi.org/10.1016/S0140-6736(05)67628-3
[118]  Kirsh, V.A., Peters, U., Mayne, S.T., Subar, A.F., Chatterjee, N., Johnson, C.C. and Hayes, R.B. (2007) Prospective Study of Fruit and Vegetable Intake and Risk of Prostate Cancer. Journal of the National Cancer Institute, 99, 1200-1209.
https://doi.org/10.1093/jnci/djm065
[119]  Traka, M. (2010) Broccoli Consumption Interferes with Prostate Cancer Progression: Mechanisms of Action. Acta Horticulturae, 867, 19-25.
https://doi.org/10.17660/ActaHortic.2010.867.1
[120]  Seow, A., Yuan, J.M., Sun, C.L., Van Den Berg, D., Lee, H.P. and Yu, M.C. (2002) Dietary Isothiocyanates, Glutathione S-Transferase Polymorphisms and Colorectal Cancer Risk in the Singapore Chinese Health Study. Carcinogenesis, 23, 2055-2061.
https://doi.org/10.1093/carcin/23.12.2055
[121]  London, S.J., Yuan, J.M., Chung, F.L., Gao, Y.T., Coetzee, G.A., Ross, R.K. and Yu, M.C. (2000) Isothiocyanates, Glutathione S-Transferase M1 and T1 Polymorphisms, and Lung-Cancer Risk: A Propective Study of Men in Shanghai, China. The Lancet, 356, 724-729.
https://doi.org/10.1016/S0140-6736(00)02631-3
[122]  Fowke, J.H., Chung, F.L., Jin, F., Qi, D., Cai, Q., Conaway, C., Cheng, J.R., Shu, X.O., Gao, Y.T. and Zheng, W. (2003) Urinary Isothiocyanate Levels, brassica, and Human Breast Cancer. Cancer Research, 63, 3980-3986.
[123]  Joseph, M.A., Moysich, K.B., Freudenheim, J.L., Shields, P.G., Bowman, E.D., Zhamg, Y., Marshall, J.R. and Ambrosone, C.B. (2004) Cruciferous Vegetables, Generic Polymorphism in Glutathione S-Transferases M1 and T1, and Protate Cancer Risk. Nutrition and Cancer, 50, 206-213.
https://doi.org/10.1207/s15327914nc5002_11
[124]  Juge, N., Mithen, R.F. and Traka, M. (2007) Molecular Basis for Chemoprevention by Sulforaphane: A Comprehensive Review. Cellular and Molecular Life Sciences, 64, 1105-1127.
https://doi.org/10.1007/s00018-007-6484-5
[125]  Zhang, Y. and Talalay, P. (1994) Anticarcinogenic Activities of Organic Isothiocyanate: Chemistry and Mechanisms. Cancer Research, 54, 1976s-1981s.
[126]  Mithen, R., Faulkner, K., Magrath, R., Rose, P., Williamson, G. and Marquez, J. (2003) Development of Isothiocyanate Enriched Broccoli and Its Enhanced Ability to Induce Phase 2 Detoxification Enzymes in Mammalian Cells. Theoretical and Applied Genetics, 106, 727-734.
https://doi.org/10.1007/s00122-002-1123-x
[127]  Rosa EAS, Heaney RK, Fenewick GR, Portas CAM. (1997) Glucosinolates in Crop Plants. Horticultural Reviews, 19, 99-215.
[128]  Abbaoui, B., Lucas, C.R. and Riedl, K.M. (2018) Cruciferous Vegetables, Isothiocyanates, and Bladder Cancer Prevention. Molecular Nutrition & Food Research, 62, 1-50.
https://doi.org/10.1002/mnfr.201800079
[129]  Dorant, E., van Den Brandt, A., Goldbohm, R.A. and Sturnmans, F. (1996) Comsumption of Onions and a Reduced Risk of Stomach Carcinoma. Gastroenterology, 110, 12-20.
https://doi.org/10.1053/gast.1996.v110.pm8536847
[130]  You, W.C., Li, J.Y., Zhang, L., Jin, M.L., Chang, Y.S., Ma, J.L. and Pan, K.F. (2005) Etiology and Prevention of Gastric Cancer: A Population Study in High Risk Area of China. Chinese Journal of Digestive Disease, 6, 149-154.
https://doi.org/10.1111/j.1443-9573.2005.00222.x
[131]  Galeone, C., Pelucchi, C., Levi, F., Negri, E., Franceschi, S., Talamini, R., Giacosa, A. and La Vecchia, C. (2006) Onion and Garlic Use and Human Cancer. American Journal of Clinical Nutrition, 84, 1027-1032.
https://doi.org/10.1093/ajcn/84.5.1027
[132]  Grant, W.B. (2004) A Multicountry Ecologic Study of Risk and Risk Reduction Factors for Prostate Cancer Mortality. European Urology, 45, 271-279.
https://doi.org/10.1016/j.eururo.2003.08.018
[133]  Shon, M.Y., Choi, S.D., Kahng, G.G., Nam, S.H. and Sung, N.J. (2004) Antimutagenic, Antioxidant and Free Radical Scavenging Activity of Ethyl Acetate Extracts from White, Yellow and Red Onions. Food and Chemical Toxicology, 42, 659-666.
https://doi.org/10.1016/j.fct.2003.12.002
[134]  Yang, J., Meyers, K.J., vanderHeide, J. and Liu, R.H. (2004) Varietal Differences in Phenolic Content and Antioxidant and Antiproliferative Activities of Onions. Journal of Agricultural and Food Chemistry, 52, 6787-6793.
https://doi.org/10.1021/jf0307144
[135]  Kim, J.Y. and Kwon, O. (2009) Garlic Intake and Cancer Risk: An Analysis Using the Food and Drug Administration’s Evidence-Based Review System for the Scientific Evaluation of Health Claims. American Journal of Clinical Nutrition, 89, 257-264.
https://doi.org/10.3945/ajcn.2008.26142
[136]  Salem, S., Salahi, M., Mohseni, M., Ahmadi, H., Mehrsai, A., Jahani, Y. and Pourmand, G. (2011) Major Dietary Factors and Prostate Cancer Risk: A Prospective Multicenter Case-Control Study. Nutrition and Cancer, 63, 21-27.
[137]  Iciek, M., Kwiecien, I. and Wlodek, L. (2009) Biological Properties of Garlic and Garlic-Derived Organosulfur Compounds. Environmental and Molecular Mutagenesis, 50, 247-265.
https://doi.org/10.1002/em.20474
[138]  Melino, S., Sabelli, R. and Paci, M. (2011) Allyl Sulfur Compounds and Cellular Detoxification System: Effects and Perspectives in Cancer Therapy. Amino Acids, 41, 103-112.
https://doi.org/10.1007/s00726-010-0522-6
[139]  You, W.C., Zhang, L., Gail, M.H., Ma, J.L., Chang, Y.S., Blot, W.J., Li, J.Y., Zhao, C.L., Liu, W.D., Li, H.Q., Hu, Y.R., Bravo, J.C., Correa, P., Xu, G.W. and Fraumeni, J.F. (1998) Helicobacter pylori Infection, Garlic Intake and Precancerous Lesions in a Chinese Population at Low Risk of Gastric Cancer. International Journal of Epidemiology, 27, 941-944.
https://doi.org/10.1093/ije/27.6.941
[140]  Tanaka, S., Haruma, K., Kunihiro, M., Nagata, S., Kitadai, Y., Manabe, N., Sumii, M., Yoshihara, M., Kajiyama, G. and Chayama, K. (2004) Effects of Aged Garlic Extract (AGE) on Colorectal Adenomas: A Double-Blinded Study. Hiroshima Journal of Medical Sciences, 53, 39-45.
[141]  Fleischauer, A.T., Poole, C. and Arab, L. (2000) Garlic Consumption and Cancer Prevention: Meta-Analyses of Colorectal and Stomach Cancers. American Journal of Clinical Nutrition, 72, 1047-1052.
https://doi.org/10.1093/ajcn/72.4.1047
[142]  Hsing, A.W., Chokkalingam, A.P., Gao, Y.T., Madigan, M., Deng, J., Gridley, G. and Fraumeni, J.F. (2002) Allium Vegetables and Risk of Prostate Cancer: A Population-Based Study. Journal of the National Cancer Institute, 94, 1648-1651.
https://doi.org/10.1093/jnci/94.21.1648
[143]  Challier, B., Perarnau, J.M. and Viel, J.F. (1998) Garlic, Onion and Cereal Fibre as Protective Factors for Breast Cancer: A French Case-Control Study. European Journal of Epidemiology, 14, 737-747.
https://doi.org/10.1023/A:1007512825851
[144]  Galeone, C., Pelucchi, C., Dal Maso, L., Negri, E., Montella, M., Zucchetto, A., Talamini, R. and La Vecchia, C. (2009) Allium Vegetables Intake and Endometrial Cancer Risk. Public Health Nutrition, 12, 1576-1579.
https://doi.org/10.1017/S1368980008003820
[145]  Satia, J.A., Littman, A., Slatore, C.G., Galanko, J.A. and White, E. (2009) Associations of Herbal and Specialty Supplements with Lung and Colorectal Cancer Risk in the Vitamins and Lifestyle Study. Cancer Epidemiology Biomarkers & Prevention, 18, 1419-1428.
https://doi.org/10.1158/1055-9965.EPI-09-0038
[146]  Wang, Y., Tian, W. and Ma, X. (2012) Inhibitory Effects of Onion (Allium cepa L.) Extract on Proliferation of Cancer Cells and Adipocytes via Inhibiting Fatty Acid Synthase. Asian Pacific Journal of Cancer Prevention, 13, 5573-5579.
https://doi.org/10.7314/APJCP.2012.13.11.5573
[147]  Burney, P.G., Comstock, G.W. and Morris, J.S. (1989) Serologic Precursors of Cancer: Serum Micronutrients and the Subsequent Risk of Pancreatic Cancer. American Journal of Clinical Nutrition, 49, 895-900.
https://doi.org/10.1093/ajcn/49.5.895
[148]  Van Eenwyk, J., Davis, F.G. and Bowen, P.E. (1991) Dietary and Serum Carotenoids and Cervical Intraepithelial Neoplasia. International Journal of Cancer, 48, 34-38.
https://doi.org/10.1002/ijc.2910480107
[149]  Franceschi, S., Bidoli, E., La Vecchia, C., Talamini, R., D’Avanzo, B. and Negri, E. (1994) Tomatoes and Risk of Digestive-Tract Cancers. International Journal of Cancer, 59, 181-184.
https://doi.org/10.1002/ijc.2910590207
[150]  Helzlsouer, K.J., Comstock, G.W. and Morris, J.S. (1989) Selenium, Lycopene, Alpha-Tocopherol, Beta-Carotene, Retinol, and Subsequent Bladder Cancer. Cancer Research, 49, 6144-6148.
[151]  Gann, P.H., Ma, J. and Giovannucci, E. (1999) Lower Prostate Cancer Risk in Men with Elevated Plasma Lycopene Levels: Results of a Prospective Analysis. Cancer Research, 59, 1225-1230.
[152]  Yuan, J.M., Ross, R.K., Gao, Y.T., Qu, Y.H., Chu, X.D. and Yu, M.C. (2004) Prediagnostic Levels of Serum Micronutrients in Relation to Risk of Gastric Cancer in Shanghai, China. Cancer Epidemiology Biomarkers & Prevention, 13, 1772-1780.
[153]  Wakai, K., Ando, M. and Ozasa, K. (2005) Updated Information on Risk Factors for Lung Cancer: Findings from the JACC Study. Journal of Epidemiology, 15, S134-S139.
https://doi.org/10.2188/jea.15.S134
[154]  Giovannucci, E. (1999) Tomatoes, Tomato Based Products, Lycopene and Cancer: Review of the Epidemiological Literature. Journal of the National Cancer Institute, 91, 917-331.
https://doi.org/10.1093/jnci/91.4.317
[155]  Jang, J. and Surh, Y. (2003) Potentiation of Cellular Antioxidant Capacity by Bcl-2: Implications for Its Antiapoptotic Function. Biochemical Pharmacology, 66, 1371-1379.
https://doi.org/10.1016/S0006-2952(03)00487-8
[156]  Hadley, C.W., Miller, E.C., Schwartz, S.J. and Clinton, S.K. (2002) Tomatoes, Lycopene, and Prostate Cancer: Progress and Promise. Experimental Biology and Medicine, 227, 869-880.
https://doi.org/10.1177/153537020222701006
[157]  Giovannucci, E., Ashcerio, A. and Rimm, E.B. (1995) Intake of Carotenoids and Retinol in Relation to Risk of Prostate Cancer. Journal of the National Cancer Institute, 87, 1767-1776.
https://doi.org/10.1093/jnci/87.23.1767
[158]  Clark, R. and Lee, S.H. (2016) Anticancer Properties of Capsaicin against Human Cancer. Anticancer Research, 36, 837-844.
[159]  Nagase, H., Sasaki, K., Kito, H., Haga, A. and Sato, T. (1998) Inhibitory Effect of Delphinidin from Solanum Melongena on Human Fibrosarcoma HT-1080 Invasiveness in Vitro. Planta Medica, 64, 216-219.
https://doi.org/10.1055/s-2006-957412
[160]  Goldwyn, S., Lazinskyand, A., Wei, H. (2000) Promotion of Health by Soy Isoflavones: Efficacy, Benefitand Safety Concerns. Drug Metabolism and Drug Interactions, 17, 261-289.
https://doi.org/10.1515/DMDI.2000.17.1-4.261
[161]  Sarkar, F.H. and Li, Y. (2006) Isoflavones, Soybean Phytoestrogens, and Cancer. In: Awad, A.B. and Bradford, P.G., Eds., Nutrition and Cancer Prevention, CRC Press, Boca Raton, 295-312.
[162]  Ziegler, R.G., Hooverand, R.N. and Hildeshein, R.N. (1993) Migration Patterns and Breast Cancer Risk in Asian-America Women. Journal of the National Cancer Institute, 85, 1819-1827.
https://doi.org/10.1093/jnci/85.22.1819
[163]  Lamartiniere, C. (2000) Protection against Breast Cancer with Genistein: A Component of Soy. American Journal of Clinical Nutrition, 71, 1705S-1707S.
https://doi.org/10.1093/ajcn/71.6.1705S
[164]  Steiner, C., Arnould, S., Scalbert, A. and Manach, C. (2008) Isoflavones and the Prevention of Breast and Prostate Cancer: New Perspectives Opened by Nutrigenomics. British Journal of Nutrition, 99, 78-108.
https://doi.org/10.1017/S0007114508965788
[165]  Messina, M.J. and Wood, C.E. (2008) Soy Isoflavones, Estrogen Therapy, and Breast Cancer Risk: Analysis and Commentary. Nutrition Journal, 7, 17.
https://doi.org/10.1186/1475-2891-7-17
[166]  Dong, J.Y. and Qin, L.Q. (2011) Soy Isoflavones Consumption and Risk of Breast Cancer Incidence or Recurrence: A Meta-Analysis of Prospective Studies. Breast Cancer Research and Treatment, 125, 315-323.
https://doi.org/10.1007/s10549-010-1270-8
[167]  Jiang, H.Y., Lv, F.J. and Tai, J.Q. (2000) Bioactive Components of Soybean and Their Function. Soybean Science, 19, 160-164.
[168]  Sarkar, F.H. and Li, Y. (2003) Soy Isoflavones and Cancer Prevention. Cancer Investigation, 21, 744-757.
https://doi.org/10.1081/CNV-120023773
[169]  Zaini, R., Clench, M.R. and Maitre, C.L. (2011) Bioactive Chemicals from Carrot (Daucus carota) Juice Extracts for the Treatment of Leukemia. Journal of Medicinal Food, 14, 1303-1312.
https://doi.org/10.1089/jmf.2010.0284
[170]  Larsen, M.K., Christensen, L.P., Vach, W., Hoitinga, R.J. and Brant, K. (2005) Inhibitory Effects of Feeding with Carrots or Falcarinol on Development of Azoxymethame-Induced Preneoplastic Lesions in the Rat Colon. Journal of Agricultural and Food Chemistry, 53, 1823-1827.
https://doi.org/10.1021/jf048519s
[171]  Purup, S., Larsen, E. and Christesen, L.P. (2009) Differential Effects of Falcarinol and Related Aliphatic C17-Polyacetylenes on Intestinal Cell Proliferation. Journal of Agricultural and Food Chemistry, 57, 8290-8296.
https://doi.org/10.1021/jf901503a
[172]  Pisani, P., Berrino, F., Macaluso, M., Pastorino, U., Crosignani, P. and Baldasseroni, A. (1986) Carrots, Green Vegetables and Lung Cancer: A Case-Control Study. International Journal of Epidemiology, 15, 463-468.
https://doi.org/10.1093/ije/15.4.463
[173]  Mullie, P. and Clarys, P. (2011) Association between Cardiovascular Disease Risk Factor Knowledge and Lifestyle. Food and Nutrition Research, 2, 1048-1053.
https://doi.org/10.4236/fns.2011.210140
[174]  Roth, G.A., Forouzanfar, M.H., Moran, A.E., Barber, R., Nguyen, G., Feigin, V.L., Murray, C.J. (2015) Demographic and Epidemiologic Drivers of Global Cardiovascular Mortality. New England Journal of Medicine, 372, 1333-1341.
https://doi.org/10.1056/NEJMoa1406656
[175]  Liu, S., Lee I.M., Ajani, U., Cole, S.R., Buring, J.E. and Manson, J.E. (2001) Intake of Vegetables Rich in Carotenoids and Risk of Coronary Heart Disease in Men: The Physicians’ Health Study. International Journal of Epidemiologyiol, 30, 130-135.
https://doi.org/10.1093/ije/30.1.130
[176]  American Heart Association (AHA) (2017) Heart and Stroke Statistical Update. American Heart Association, Dallas, TX.
[177]  Yeh, Y.Y. and Liu, L. (2001) Cholesterol-Lowering Effect of Garlic Extracts and Organosulfur Compounds: Human and Animal Studies. Journal of Nutrition, 131, 989-993.
https://doi.org/10.1093/jn/131.3.989S
[178]  Moriguchi, T., Takasugi, N. and Itakura, Y. (2001) The Effects of Aged Garlic Extract on Lipid Peroxidation and the Deformability of Erythrocytes. Journal of Nutrition, 131, 1016-1019.
https://doi.org/10.1093/jn/131.3.1016S
[179]  Chang, H.S., Yamato, O., Yamasaki, M. and Maede, Y. (2005) Modulatory Influence of Sodium 2-Propenylthiosulfate from Garlic on Cyclooxygenase Activity in Canine Platelets: Possible Mechanism for the Anti-Aggregatory Effect. Prostaglandins, Leukotrienes and Essential Fatty Acids, 72, 351-355.
https://doi.org/10.1016/j.plefa.2005.01.003
[180]  Osmont, K.S., Arnt, C.R. and Goldman, I.L. (2003) Temporal Aspects of Onion-Induced Antiplatelet Activity. Plant Foods for Human Nutrition, 58, 27-40.
https://doi.org/10.1023/A:1024062330700
[181]  Hubbard, G.P., Wolffram, S., Lovegrove, J.A. and Gibbins, J.M. (2006) Ingestion of Quercetin Inhibits Platelet Aggregation and Essential Components of the Collagen-Stimulated Platelet Activation Pathway in Man: A Pilot Study. Journal of Thrombosis and Haemostasis, 2, 2138-2145.
https://doi.org/10.1111/j.1538-7836.2004.01067.x
[182]  Briggs, W.H., Folt, J.D., Osman, H.E. and Goldman, I.L. (2001) Administration of Raw Onion Inhibits Platelet-Mediated Thrombosis in Dogs. Journal of Nutrition, 131, 2619-2622.
https://doi.org/10.1093/jn/131.10.2619
[183]  Ried, K., Frank, O.R. and Stocks, N.P. (2013) Aged Garlic Extract Reduces Blood Pressure in Hypertensives: A Dose-Response Trial. European Journal of Clinical Nutrition, 67, 64-70.
https://doi.org/10.1038/ejcn.2012.178
[184]  Freudenheim, J.L., Graham, S., Marshall, J.R., Haughey, B.P. and Wilkinson, G. (1990) A Case-Control Study of Diet and Rectal Cancer in Western New York. American Journal of Epidemiology, 131, 612-624.
https://doi.org/10.1093/oxfordjournals.aje.a115545
[185]  Knekt, P., Jarvinen, R., Reunanen, A. and Maatela, J. (1996) Flavonoid Intake and Coronary Mortality in Finland: A Cohort Study. BMJ, 312, 478-481.
https://doi.org/10.1136/bmj.312.7029.478
[186]  Rastogi, T., Reddy, K.S., Vaz, M., Spiegelman, D., Prabhakaran, D., Willett, W.C. and Ascherio, A. (2004) Diet and Risk of Ischemic Heart Disease in India. American Journal of Clinical Nutrition, 79, 582-592.
https://doi.org/10.1093/ajcn/79.4.582
[187]  Saluk, J., Bijak, M., Kolodziejczyk-Czepas, J., Posmyk, M., Janas, K. and Wachowicz, B. (2012) Anthocyanins from Red Cabbage Extract—Evidence of Protective Effects on Blood Platelets. Open Life Sciences, 7, 655-663.
https://doi.org/10.2478/s11535-012-0057-9
[188]  Manchali, S., Murthy, K.N.C. and Patil, B.S. (2012) Crucial Facts about Health Benefits of Popular Cruciferous Vegetables. Journal of Functional Foods, 4, 94-106.
https://doi.org/10.1016/j.jff.2011.08.004
[189]  Jeffery, E.H. and Araya, M. (2009) Physiological Effects of Broccoli Consumption. Phytochemistry Reviews, 8, 283-298.
https://doi.org/10.1007/s11101-008-9106-4
[190]  Murashima, M., Watanabe, S., Zhuo, X.G., Uehara, M. and Kurashige, A. (2004) Phase 1 Study of Multiple Biomarkers for Metabolism and Oxidative Stress after One-Week Intake of Broccoli Sprouts. BioFactors, 22, 271-275.
https://doi.org/10.1002/biof.5520220154
[191]  Jorge, P.A., Neyra, L.C. and Osaki, R.M. (1998) Effect of Eggplant on Plasma Lipid Levels, Lipidic Peroxidation and Reversion of Endothelial Dysfunction in Experimental Hypercholesterolemia. Arquivos Brasileiros de Cardiologia, 70, 87-91.
https://doi.org/10.1590/S0066-782X1998000200004
[192]  Guimaraes, P.R., Galvao, A.M., Batista, C.M., Azevedo, G.S., Oliveira, R.D., Lamounier, R., Freire, N., Barros, A., Sakurai, E., Oliveira, J., Vieira, E. and Alvarez-Leite, J. (2000) Eggplant (Solanum melongena) Infusion has a Modest and Transitory Effect on Hypercholesterolemic Subjects. Brazilian Journal of Medical and Biological Research, 33, 1027-1036.
https://doi.org/10.1590/S0100-879X2000000900006
[193]  Kwon, Y.I., Apostolidis, E. and Shetty, K. (2008) In Vitro Studies of Eggplant (Solanum melongena) Phenolics as Inhibitors of Key Enzymes Relevant for Type 2 Diabetes and Hypertension. Bioresource Technology, 99, 2981-2988.
https://doi.org/10.1016/j.biortech.2007.06.035
[194]  Anderson, J.W., Deakins, D.A., Floore, T.L., Smith, B.M. and Whitis, S.E. (1990) Dietary Fiber and Coronary Heart Disease. Critical Reviews in Food Science and Nutrition, 29, 95-147.
https://doi.org/10.1080/10408399009527518
[195]  Menotti, A., Kromhout, D., Blackburn, H., Fidanza, F., Buzina, R. and Nissinen, A. (1999) Food Intake Patterns and 25-Year Mortality from Coronary Heart Disease: Cross-Cultural Correlations in the Seven Countries Study. European Journal of Epidemiology, 15, 507-515.
https://doi.org/10.1023/A:1007529206050
[196]  Nothlings, U., Schulze, M.B., Weikert, C., Boeing, H., Van der Schouw, Y.T., Bamia, C. and Peeters, P.H. (2008) Intake of Vegetables, Legumes, and Fruit, and Risk for All-Cause, Cardiovascular, and Cancer Mortality in a European Diabetic Population. Journal of Nutrition, 138, 775-781.
https://doi.org/10.1093/jn/138.4.775
[197]  Lattimer, J.M. and Haub, M.D. (2010) Effects of Dietary Fiber and Its Components on Metabolic Health. Nutrients, 2, 1266-1289.
https://doi.org/10.3390/nu2121266
[198]  Nicolle, C., Cardinault, N., Aprikian, O., Busserolles, J., Grolier, P., Rock, E., Demigné, C., Mazur, A., Scalbert, A., Amouroux, P. and Rémésy, C. (2003) Effect of Carrot Intake on Cholesterol Metabolism and on Antioxidant Status in Cholesterol-Fed Rat. European Journal of Nutrition, 42, 254-261.
https://doi.org/10.1007/s00394-003-0419-1
[199]  Gramenzi, A., Gentile, A., Fasoli, M., Negri, E., Parazzini, F. and La Vecchia, C. (1990) Association between Certain Foods and Risk of Acute Myocardial Infarction in Women. BMJ, 300, 771-773.
https://doi.org/10.1136/bmj.300.6727.771
[200]  Gilani, A.H., Shaheeri, F., Saeed, S.A., Bibi, S., Irfamillah-Sadiq, M. and Faiz, S. (2000) Hypotensive Action of Coumarin Glycoside from Daucus Carot. Phytomedicine, 7, 423-426.
https://doi.org/10.1016/S0944-7113(00)80064-1
[201]  Carter, P., Gray, L.J., Troughton, J., Khunti, K. and Davies, M.J. (2010) Fruit and Vegetable Intake and Incidence of Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis. BMJ, 341, c4229.
https://doi.org/10.1136/bmj.c4229
[202]  Bazzano, L.A., Li, T.Y., Joshipura, K.J. and Hu, F.B. (2008) Intake of Fruit, Vegetables and Fruit Juices and Risk of Diabetes in Women. Diabetes Care, 31, 1311-1317.
https://doi.org/10.2337/dc08-0080
[203]  Khan, B.A., Abraham, A. and Leelamma, S. (1995) Hypoglycemic Action of Murraya koeingii (Curry Leaf) and Brassica juncea (Mustard): Mechanism of Action. Indian Journal of Biochemistry & Biophysics, 32, 106-108.
[204]  Tundis, R., Loizzo, M.R. and Menichini, F. (2010) Natural Products as Alpha-Amylase and Alpha-Glucosidase Inhibitors and Their Hypoglycaemic Potential in the Treatment of Diabetes: An Update. Mini-Reviews in Medicinal Chemistry, 10, 315-331.
https://doi.org/10.2174/138955710791331007
[205]  Yoshikawa, M., Murakami, T., Kadoya, M., Yamahara, J. and Matsuda, H. (1996) Medicinal Foodstuff. III. Sugar Beet. Hypoglicemic Oleanolic Acid Oligoglycosides, Betavulgarosides I, II, III, and IV, from the Root of Beta vulgaris L. (Chenopodiaceae). Chemical and Pharmaceutical Bulletin, 44, 1212-1217.
https://doi.org/10.1248/cpb.44.1212
[206]  American Diabetes Association (ADA) (2016) Standards of Care. Diabetes Care, 39, S1-S119.
[207]  Gu, J.F., Zheng, Z.Y., Yuan, J.R., Zhao, B.J., Wang, C.F., Zhang, L., Xu, Q.Y., Yin, Q.W., Feng, L. and Jia, X.B. (2015) Comparison on Hypoglycemic and Antioxidant Activities of the Fresh and Dried Portulaca oleracea L. in Insulin-Resistant HepG2 Cells and Streptozotocin-Induced C57BL/6J Diabetic Mice. Journal of Ethnopharmacologyogy, 161, 214-223.
https://doi.org/10.1016/j.jep.2014.12.002
[208]  Wainstein, J., Landau, Z., Dayan, Y.B., Jakubowicz, D., Grothe, T., Perrinjaquet-Moccetti, T. and Boaz, M. (2016) Purslane Extract and Glucose Homeostasis in Adults with Type 2 Diabetes: A Double-Blind, Placebo-Controlled Clinical Trial of Efficacy and Safety. Journal of Medicinal Food, 19, 133-140.
https://doi.org/10.1089/jmf.2015.0090
[209]  Swamy, K.R.M., Nath, P. and Ahuja, K.G. (2013) Vegetables for Human Nutrition and Health. In: Nath, P., Ed., The Basics of Human Civilization-Food, Agriculture and Humanity, Volume-II-Food, Prem Nath Agricultural Science Foundation (PNASF), Bangalore & New India Publishing Agency (NIPA), New Delhi, India, 145-198.
[210]  El-Demerdash, F.M., Yousef, M.I. and El-Naga, N.A. (2005) Biochemical Study on the Hypoglycemic Effects of Onion and Garlic in Alloxan-Induced Diabetic Rats. Food and Chemical Toxicology, 43, 57-63.
https://doi.org/10.1016/j.fct.2004.08.012
[211]  Ogunmodede, O.S., Saalu, L.C., Ogunlade, B., Akunna, G.G. and Oyewopo, A.O. (2012) An Evaluation of the Hypoglycemic, Antioxidant and Hepatoprotective Potentials of Onion (Allium cepa L.) on Alloxan-Induced Diabetic Rabbits. International Journal of Pharmacology, 8, 21-29.
https://doi.org/10.3923/ijp.2012.21.29
[212]  Yoshinari, O., Shiojima, Y. and Igarashi, K. (2012) Anti-Obesity Effects of Onion Extract in Zucker Diabetic Fatty Rats. Nutrients, 4, 1518-1526.
https://doi.org/10.3390/nu4101518
[213]  Wang, H., Kruszewki, A. and Brautigan, D.L. (2005) Cellular Chromium Activation of Insulin Receptor Kinase. Biochemistry, 44, 8167-8175.
https://doi.org/10.1021/bi0473152
[214]  Chau, C.F., Chen, C.H. and Lee, M.H. (2004) Comparison of the Characteristics, Functional Properties, and in Vitro Hypoglycemic Effects of Various Carrot Insoluble Fiber-Rich Fractions. Lebensmittel-Wissenshaff und Technologie, 37, 155-160.
https://doi.org/10.1016/j.lwt.2003.08.001
[215]  Coyne, T., Ibiebele, T.I. and Baade, P.D. (2005) Diabetes Mellitus and Serum Carotenoids: Findings of a Population-Based Study in Queensland, Australia. American Journal of Clinical Nutrition, 82, 685-693.
https://doi.org/10.1093/ajcn/82.3.685
[216]  Chen, Q., Chan, L.L.Y. and Li, E. (2003) Bitter Melon (Momordica charantia) Reduces Adiposity, Lowers Serum Insulin and Normalizes Glucose Tolerance in Rats Fed a High Fat Diet. Journal of Nutrition, 133, 1088-1093.
https://doi.org/10.1093/jn/133.4.1088
[217]  Patil, B., Jayaprakasha, G.K. and Vikram, A. (2012) Indigenous Crops of Asia and Southeast Asia: Exploring Health-Promoting Properties. HortScience, 47, 821-827.
https://doi.org/10.21273/HORTSCI.47.7.821
[218]  Chao, P.M. (2015) One More Support for Recruiting Bitter Melon in Therapeutic Diet for Diabetes and Its Comorbidity Management-Bitter Melon Ameliorates Hepatic Steatosis Related with Hyperglycemia. BIT’s 4th Annual World Congress of Diabetes, Kaohsiung, 13-16 November 2014, 236.
[219]  Ahmad, N., Hassan, M., Halder, H. and Bennoor, K. (1999) Effect of Momordica charantia (Karolla) Extracts on Fasting and Postprandial Serum Glucose Levels in NIDDM Patients. Bangladesh Medical Research Council Bulletin, 25, 11.
[220]  Yeh, G., Eisenberg, D., Kaptchuk, T. and Phillips, R. (2003) Systematic Review of Herbs and Dietary Supplements for Glycemic Control in Diabetes. Diabetes Care, 26, 1277.
https://doi.org/10.2337/diacare.26.4.1277
[221]  Chen, J., Tian, R., Qiu, M., Lu, L., Zheng, Y. and Zhang, Z. (2008) Trinorcucurbitane and Cucurbitane Triterpenoids from the Roots of Momordica charantia. Phytochemistry, 69, 1043-1048.
https://doi.org/10.1016/j.phytochem.2007.10.020
[222]  Saxena, A. and Vikram, N. (2004) Role of Selected Indian Plants in Management of Type 2 Diabetes: A Review. Journal of Alternative and Complementary Medicine, 10, 369-378.
https://doi.org/10.1089/107555304323062365
[223]  Singh, L.W. (2011) Traditional Medicinal Plants of Manipur as Anti-Diabetics. Journal of Medicinal Plant Research, 5, 677-687.
[224]  Villegas, R., Gao, Y.T., Yang, G., Li, H.L., Elasy, T.A., Zheng, W. and Shu, X.O. (2008) Legume and Soy Food Intake and the Incidence of Type 2 Diabetes in the Shanghai Women’s Health Study. American Journal of Clinical Nutrition, 87, 162-167.

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