We investigated preparation of film dosage form (FD) from natural polysaccharides using the casting method without organic solvents, heating or pH control. Ferulic acid (FA) and catechin were employed as model compounds incorporated in the FD, and the release profile of each compound from the form was investigated in the limited medium. Film formation was affected by the addition of the model compound to the polysaccharide solution. Rigid FD was obtained with 2% low-molecular-weight alginate (L-ALG; thickness, 65 µm), and it hardened after the addition of 0.5% polygalacturonic acid, although the thickness of the film did not change. The FDs immediately released the model compound, and the forms dissolved in phosphate-buffered saline. FD modification did not affect the FA release rate except in the early stage. FD would be a useful dosage form, especially for preventing or treating localized problems in the oral cavity.
A. Nishida, M. Yamada, T. Kanazawa, Y. Takashima, K. Ouchi and H. Okada, “Sustained-release of protein from biodegradable sericin film, gel and sponge,” International Journal of Pharmaceutics, Vol. 407, 2011, pp. 44-52.
M. Nishimura, K. Matsuura, T. Tsukioka, H. Yamashita, N. Inagaki, T. Sugiyama and Y. Itoh, “In vitro and in vivo characteristics of prochlorperazine oral disintegration film,” International Journal of Pharmaceutics, Vol. 368, 2009, pp. 98-102.
M. F. Senyucel, M. B. Kologlu, R. Vargun, C, Akbay, F. N. Sarac, N. Renda, N. Hasirci, G. Gollu and H. Dindar, “The effect of local and sustained release of fibroblast growth factor on wound healing in esophageal anastomoses,” Journal of Pediatric Surgery, Vol. 43, 2008, pp. 290-295.
A. M. Smith, A. Ingham, L. M. Grover and Y. Perrie, “Polymer film formulations for the preparation of enteric pharmaceutical capsules,” Journal of Pharmacy and Pharmacology, Vol. 62, 2010, pp. 167-172.
J. Alamed, W. Chaiyasit, D. J. McClements and E. A. Decker, “Relationships between free radical scavenging and antioxidant activity in foods,” Journal of Agricultural and Food Chemistry, Vol. 57, No. 7, 2009, pp. 2969- 2976.
M. Ohnishi, T. Matsuo, T. Tsuno, A. Hosoda, E. Nomura, H. Taniguchi, H. Sasaki and H. Morishita, “Antioxidant activity and hypoglycemic effect of ferulic acid in STZ- induced diabetic mice and KK-Ay mice,” Biofactors, Vol. 21, No. 1-47, 2004, pp. 315-319.
A. Suzuki, D. Kagawa, A. Fujii, R. Ochiai, I. Tokimitsu and I. Saito, “Short- and long-term effects of ferulic acid on blood pressure in spontaneously hypertensive rats,” American Journal of Hypertension, Vol. 15, No. 4, 2002, pp. 351-357.
B. Wang, J. Ouyang, Y. Liu, J. Yang, L. Wei, K. Li and H. Yang, “Sodium ferulate inhibits atherosclerogenesis in hyperlipidemia rabbits,“ Journal of Cardiovascular Pharmacology, Vol. 43, No. 4, 2004, pp. 549-554.
X. Xu, X. D. Zhou and C. D. Wu, “The tea catechin epigallocatechin gallate suppresses cariogenic virulence factors of Streptococcus mutans,” Antimicrobial Agents and Chemotherapy, Vol. 55, No. 3, 2011, pp. 1229-1236.
S. M. S. Miguel, L. A. Opperman, E. P. Allen, J. Zielinski and K. K. H. Svoboda, “Antioxidants counteract nicotine and promote migration via RacGTP in oral fibroblast cells,” Journal of Periodontology, Vol. 81, No. 11, 2010, pp. 1675-1690.
M. Kohno, S. Suzuki,T. Kanaya, T. Yoshino, Y. Matsuura, M. Asada and S. Kitamura, “Structural characterization of the extracellular polysaccharide produced by Bifidobacterium longum JBL05,” Carbohydate Polymers, Vol. 77, 2009, pp. 351-357.
T. Fu, J. Liang, G. Han, L. Lv and N. Li, “Simultaneous determination of the major active components of tea polyphenols in rat plasma by a simple and specific HPLC assay,” Journal of Chromatography B, Vol. 875, 2008, pp. 363-367.
B. Nauntofte, J. O. Tenovuo and F. Lagerlof, “Secretion and composition of saliva. In Dental Caries the Disease and Its Clinical Management“ (O. Fejerskov and E. A. M. Kidd, Eds. Chapter 2, pp. 7-27, Blackwell Munksgaad, Oxford, UK), 2003.