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-  2018 


DOI: 10.13543/j.bhxbzr.2018.05.010

Keywords: 代谢工程,芳香族化合物,糖代谢网络,原子经济性,
metabolic engineering
,aromatic compounds,glycometabolic network,atomic economy

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Abstract:In order to reduce harmful effects on the environment, sustainable development of the modern chemical industry requires an alternative to fossil fuels as the source of organic compounds. Metabolic engineering has become a promising alternative approach for synthesis of compounds originally derived from petroleum. Currently, a variety of compounds can be synthesized on an industrial scale by using both metabolic engineering and synthetic biology methods in microorganisms. However, some limitations still exist in metabolic engineering and synthetic biology approaches. In order to further the development of metabolic engineering and synthetic biology methods, our research group in Beijing University of Chemical Technology has developed many new methods for the production of a wide range of target compounds. Using these novel methods, our group has reported the biosynthesis of aromatic compounds, rearrangement of microbial glycometabolic networks and improvements in atom economy. Our work offers ways to address the drawbacks in current methods for the biosynthesis of products originally derived from petroleum using engineered microorganisms.


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