可见光引发的活性接枝聚合及其生物应用

活性光接枝聚合具有步骤简单、反应活化能低、反应时间/区域易于控制的特点，是表面改性的重要方法。与紫外光引发体系相比，可见光辐照反应条件更加温和、副反应少、对生物活性物质无损害，在生物相关领域具有更广阔的应用前景。基于多年的研究基础，北京化工大学有机材料表面工程研究室近年来开发了基于硫杂蒽酮衍生物的可见光引发表面活性接枝新方法。本文系统介绍了相关方法涉及的反应机理及其在酶固定化、生物芯片及细胞包覆方面的应用，并对今后的发展前景予以展望。
Abstract：Photo-induced living graft polymerization has become one of most important surface modification methods due to its advantages of simple operation, low activation energy and spatial/temporal controllability. Compared to the more common UV initiation systems, visible light irradiation has lower energy and has no adverse effects on biologically active substances. Based on the results of two decades of research in the photografting field, researchers in Organic Materials Surface Science and Engineering Lab in Beijing University of Chemical Technology have developed a novel visible light-induced living graft polymerization strategy based on derivative of thioxanthone. Here we systematically describe the mechanism of this method and its application in enzyme immobilization, biochip formation and cell encapsulation. Finally, possible future developments in this field are discussed.