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-  2018 


DOI: 10.13543/j.bhxbzr.2018.05.012

Keywords: 抗肿瘤纳米药物,N-(2-羟丙基)甲基丙烯酰胺(HPMA),化学组成,拓扑结构,
anticancer nanomedicine
,N-(2-hydroxypropyl) methacrylamide (HPMA),chemical composition,topological structure

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Abstract:Cancer is one of the most fatal diseases and greatly threatens the health of Chinese citizens. Recent progress in nanotechnology has brought various new options for cancer treatment. Various nanostructures including nanoparticles, liposomes and polymer-drug conjugates have attracted tremendous research interest. Many polymers have been successfully applied in the development of anticancer nanomedicines. Due to their excellent biocompatibility, structural diversity and the optimal "stealth" properties, poly (N-(2-hydroxypropyl)methacrylamide) (PHPMA) copolymers have been widely used in the design of various novel nanomedicines. This work reviews the recent progress in PHPMA nanomedicines, and summarizes the influence of composition and structure on the biological properties of these nanomedicines. The interpretation of relevant structure-property correlations may provide new guidelines for the design of future PHPMA-based nanomedicines.


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