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-  2018 

术前SII、NLR、PLR在分化型甲状腺癌中的诊断价值分析 Diagnostic value of preoperative systemic immune-inflammation index, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in differentiated thyroid carcinoma

Keywords: 分化型甲状腺癌,系统性免疫性炎症指数,中性粒细胞和淋巴细胞比值,血小板和淋巴细胞比值,鉴别诊断

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目的分析系统性免疫性炎症指数(SII)、外周血中性粒细胞和淋巴细胞比值(NLR)、血小板和淋巴细胞比值(PLR)分别在分化型甲状腺癌(DTC)和甲状腺良性结节中的差异,研究SII、NLR、PLR在甲状腺良、恶性结节鉴别诊断中的价值。方法回顾性分析2014年6月—2017年12月于中国人民武装警察部队特色医学中心经手术治疗的甲状腺结节病人临床资料,根据术后病理结果将其分为DTC组和良性结节组,分别讨论SII、NLR、PLR在2组之间的差异。应用受试者操作特征曲线(ROC)分析鉴别甲状腺良、恶性结节的最佳cut-off值。结果 DTC组SII、NLR显著高于甲状腺良性结节组,差异有统计学意义(P <0.01)。2组PLR对比差异无统计学意义(P> 0.05)。由ROC曲线分析得出鉴别甲状腺良、恶性结节的SII的最佳cut-off值为520.65,敏感度为41.6%,特异度为87.0%,阳性预测值为70.0%,阴性预测值为64.8%,曲线下面积(AUC)为0.659。鉴别甲状腺良、恶性结节的NLR的最佳cut-off值为1.81,敏感度为62.4%,特异度为83.9%,阳性预测值为74.5%,阴性预测值为73.4%,AUC为0.720。结论术前高SII、NLR对DTC有一定诊断价值,临床工作中,可使用术前SII、NLR指导甲状腺良、恶性的鉴别诊断,为甲状腺结节患者的全面评估提供重要参考

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