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An Associated Research for Genetic Polymorphism of 5-HTTLPR with Post-Traumatic Stress Disorder

DOI: 10.4236/jbbs.2019.91001, PP. 1-12

Keywords: Posttraumatic Stress Disorder, Gene Polymorphism, 5-HTTLPR, Genetics

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Abstract:

The aim of this study was to investigate the influence of a polymorphism in the serotonin transporter gene (5-HTTLPR) in patients diagnosed with posttraumatic stress disorder (PTSD) in a Chinese sample of earthquake survivors. Polymerase chain reaction (PCR) amplification and amplified fragment length polymorphism (AFLP) were performed to type 5-HTTLPR promoter polymorphism in 57 PTSD patients and an equal number of healthy controls. The genotype and allele frequency distribution were analyzed and compared using various statistical methods. The frequency of LL, SL and SS genotypes in patients was found to be 5, 16 and 36 respectively, in comparison to 16, 22 and 19 in healthy controls. Fewer patients tended to be L genotype (22.8%) than controls (47.4%), but the number of patients with the S genotype was higher (77.2%) compared to controls (52.6%). The results show a statistically significant difference in genotype and allele frequency distribution between patients and controls. This research suggests that PTSD symptoms are significantly associated with 5-HTTLPR genetic polymorphism. These results add to the important research of genetics of psychiatric disorders, particularly in a Chinese context that has not been previously studied.

References

[1]  Harvey, P.D., Posner, K., Rajeevan, N., Yershova, K.V., Aslan, M. and Concato, J. (2018) Suicidal Ideation and Behavior in US Veterans with Schizophrenia or Bipolar Disorder. Journal of Psychiatric Research, 102, 216-222.
https://doi.org/10.1016/j.jpsychires.2018.04.014
[2]  Franklin, C.L., Raines, A.M., Chambliss, J.L., Walton, J.L. and Maieritsch, K.P. (2018) Examining Various Subthreshold Definitions of PTSD Using the Clinician Administered PTSD Scale for DSM-5. Journal of Affective Disorders, 234, 256-260.
https://doi.org/10.1016/j.jad.2018.03.001
[3]  Smith, N.B., Sippelb, L.M., Presseau, C., Rozek, D., Mota, N., Gordon, C., Horvath, M. and Harpaz-Rotemahi, I. (2018) Locus of Control in US Combat Veterans: Unique Associations with Posttraumatic Stress Disorder 5-Factor Model Symptom Clusters. Psychiatry Research, 268, 152-156.
https://doi.org/10.1016/j.psychres.2018.07.015
[4]  Mirhashem, R., Allen, H.C., Adams, Z.W., et al. (2017) The Intervening Role of Urgency on the Association between Childhood Maltreatment, PTSD, and Substance-Related Problems. Addictive Behaviors, 69, 98-103.
https://doi.org/10.1016/j.addbeh.2017.02.012
[5]  Seow, L.S.E., Ong, C., Mahesh, M.V., Sagayadevan, V., et al. (2016) A Systematic Review on Comorbid Post-Traumatic Stress Disorder in Schizophrenia. Schizophrenia Research, 176, 441-451.
https://doi.org/10.1016/j.schres.2016.05.004
[6]  Badour, C.L., Gros, D.F., Szafranski, D.D. and Acierno, R. (2016) Sexual Problems Predict PTSD and Depression Symptom Change Among Male OEF/OIF Veterans Completing Exposure Therapy. Psychiatry, 79, 403-417.
https://doi.org/10.1080/00332747.2016.1142774
[7]  Yeterian, J.D., Berke, D.S. and Litz, B.T. (2017) Psychosocial Rehabilitation after War Trauma with Adaptive Disclosure: Design and Rationale of a Comparative Efficacy Trial. Contemporary Clinical Trials, 61, 10-15.
https://doi.org/10.1016/j.cct.2017.07.012
[8]  Masheb, R.M., Ruser, C.B., Min, K.M., et al. (2018) Does Food Addiction Contribute to Excess Weight among Clinic Patients Seeking Weight Reduction? Examination of the Modified Yale Food Addiction Survey. Comprehensive Psychiatry, 84, 1-6.
https://doi.org/10.1016/j.comppsych.2018.03.006
[9]  Emerson, M.A., Moore, R.S. and Caetano, R. (2017) Association between Lifetime Posttraumatic Stress Disorder and Past Year Alcohol Use Disorder among American Indians/Alaska Natives and Non-Hispanic Whites. Alcoholism: Clinical and Experimental Research, 41, 576-584.
https://doi.org/10.1111/acer.13322
[10]  Verhey, R., Chibanda, D., Gibson, L., Brakarsh, J. and Seedat, S. (2018) Validation of the Posttraumatic Stress Disorder Checklist-5 (PCL-5) in a Primary Care Population with High HIV Prevalence in Zimbabwe. BMC Psychiatry, 18, 109.
https://doi.org/10.1186/s12888-018-1688-9
[11]  Alhalal, E., Ford-Gilboe, M., Wong, C. and AlBuhairan, F. (2017) Reliability and Validity of the Arabic PTSD Checklist Civilian Version (PCL-C) in Women Survivors of Intimate Partner Violence. Research in Nursing & Health, 40, 575-585.
https://doi.org/10.1002/nur.21837
[12]  Reznikov, R., Rodriguez, F., et al. (2018) Prefrontal Cortex Deep Brain Stimulation Improves Fear and Anxiety-Like Behavior and Reduces Basolateral Amygdala Activity in a Preclinical Model of Posttraumatic Stress Disorder. Neuropsychopharmacology, 43, 1099-1106.
https://doi.org/10.1038/npp.2017.207
[13]  Giordano, N.A. and Bader, C. (2018) Complexity of the Relationships of Pain, Posttraumatic Stress, and Depression in Combat-Injured Populations: An Integrative Review to Inform Evidence-Based Practice. Worldviews on Evidence-Based Nursing, 15, 113-126.
https://doi.org/10.1111/wvn.12274
[14]  Mills, K.L., Christina, M., et al. (2018) The Long-Term Impact of Post Traumatic Stress Disorder on Recovery from Heroin Dependence. Journal of Substance Abuse Treatment, 89, 60-66.
https://doi.org/10.1016/j.jsat.2018.04.001
[15]  Hu, X., Cao, X., et al. (2016) Probable Post-Traumatic Stress Disorder and Its Predictors in Disaster-Bereaved Survivors: A Longitudinal Study after the Sichuan Earthquake. Archives of Psychiatric Nursing, 30, 192-197.
https://doi.org/10.1016/j.apnu.2015.08.011
[16]  Foa, E.B., McLean, C. and, Peterson, A. (2018) Motivation to Participate in PTSD Research-Reply. JAMA, 319, 2440-2441.
https://doi.org/10.1001/jama.2018.4330
[17]  Heils, A.R. and Lesch, M.K.P. (1997) The Human Serotonin Transporter Gene Polymorphism-Basic Research and Clinical Implications. Journal of Neural Transmission, 104, 1005-1014.
https://doi.org/10.1007/BF01273314
[18]  Murphy, S., Hansen, M., et al. (2018) Alternative Models of DSM-5 PTSD: Examining Diagnostic Implications. Psychiatry Research, 262, 378-383.
https://doi.org/10.1016/j.psychres.2017.09.011
[19]  Hou, L., Qi, Y., Sun, H., Wang, G., et al. (2018) Applying Ketamine to Alleviate the PTSD-Like Effects by Regulating the HCN1-Related BDNF. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 8, 313-321.
https://doi.org/10.1016/j.pnpbp.2018.03.019
[20]  Lee, D., Liverant, G., Lowmaster, S.E. Gradusc, J.L. and Sloan, D.M. (2014) PTSD and Reasons for Living: Associations with Depressive Symptoms and Alcohol Use. Psychiatry Research, 219, 550-555.
https://doi.org/10.1016/j.psychres.2014.06.016
[21]  Murkar, A., Kent, P.C, James, C. and Merali, Z. (2018) Gastrin-Releasing Peptide Attenuates Fear Memory Reconsolidation. Behavioural Brain Research, 347, 255-262.
https://doi.org/10.1016/j.bbr.2017.11.037
[22]  Thling, J., Simmons, C., Suliman, S. and Seedat, S. (2017) Trauma Type as a Conditional Risk Factor for Posttraumatic Stress Disorder in a Referred Clinic Sample of Adolescents. Comprehensive Psychiatry, 76, 138-146.
https://doi.org/10.1016/j.comppsych.2017.05.001
[23]  Herz, N., Reuveni, I., et al. (2016) Neural Correlates of Attention Bias in Posttraumatic Stress Disorder. Clinical Neurophysiology, 127, 3268-3276.
https://doi.org/10.1016/j.clinph.2016.07.016
[24]  Broekman, B.F.P., Olff, M. and Boer, F. (2007) The Genetic Background to PTSD. Neuroscience and Biobehavioral Reviews, 31, 348-362.
https://doi.org/10.1016/j.neubiorev.2006.10.001
[25]  Aslihan, S., et al. (2010) A Prospective Study of Serotonin Transporter Gene Promoter (5-HTT Gene Linked Polymorphic Region) and Intron 2 (Variable Number of Tandem Repeats) Polymorphisms as Predictors of Trauma Response to Mild Physical Injury. DNA and Cell Biology, 29, 71-77.
https://doi.org/10.1089/dna.2009.0936
[26]  Walsh, K., Uddin, M., Soliven, R., Wildman, D.E. and Bradley-Davino, B. (2014) Associations between the SS variant of 5-HTTLPR and PTSD among Adults with Histories of Childhood Emotional Abuse: Results from Two African American Independent Samples. Journal of Affective Disorders, 161, 91-96.
https://doi.org/10.1016/j.jad.2014.02.043
[27]  Mercer, K.B. (2012) Acute and Posttraumatic Stress Symptoms in a Prospective Gene x Environment Study of a University Campus Shooting. Archives of General Psychiatry, 69, 89-97.
https://doi.org/10.1001/archgenpsychiatry.2011.109
[28]  Tian, Y., Liu, H. and Guse, L. (2015) Association of Genetic Factors and Gene-Environment Interactions with Risk of Developing Posttraumatic Stress Disorder in a Case-Control Study. Biological Research for Nursing, 17, 364-372.
https://doi.org/10.1177/1099800415588362
[29]  Wang, Z., Dewleen, G., et al. (2011) The Relationship between Combat-Related Posttraumatic Stress Disorder and the 5-HTTLPR/rs25531 Polymorphism. Depression and Anxiety, 28, 1067-1073.
https://doi.org/10.1002/da.20872
[30]  Murrough, J.W., Huang, Y., et al. (2011) Reduced Amygdala Serotonin Transporter Binding in Posttraumatic Stress Disorder. Biological Psychiatry, 70, 1033-1038.
https://doi.org/10.1016/j.biopsych.2011.07.003
[31]  Sayin, A., Kucukyildirim, S., et al. (2010) A Prospective Study of Serotonin Transporter Gene Promoter (5-HTT Gene Linked Polymorphic Region) and Intron 2 (Variable Number of Tandem Repeats) Polymorphisms as Predictors of Trauma Response to Mild Physical Injury. DNA and Cell Biology, 29, 71-77.
https://doi.org/10.1089/dna.2009.0936

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