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Mild Cognitive Impairment in Parkinson Disease: A Neuropsychological Study of 25 Patients

DOI: 10.4236/wjns.2018.84037, PP. 470-479

Keywords: MCI, PD, Neuropsychological Study, Executive Functions, Episodic Memory, Visuospatial Capacities

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Abstract:

Parkinson’s disease (PD) is associated with an increased incidence of cognitive impairment and dementia. Population-based cohort of 25 patients with incident PD underwent a large neuropsychological battery. Executive functions were the most affected cognitive domain including particularly initiation, mental flexibility and inhibition. Episodic memory and visuo-spatial functions were less affected. We found that 92% of patients were classified as having Mild Cognitive Impairment (MCI); most of them experienced PD-MCI Single-Domain (17 patients) with disturbances on executive functions. Less frequently, we identified a group of patients with multiple-domain PD-MCI demonstrating deficits on executive functions as well as on episodic memory and/or visuospatial capacities.

References

[1]  De Lau, L.M. and Breteler, M.M. (2006) Epidemiology of Parkinson’s Disease. The Lancet Neurology, 5, 525-535.
https://doi.org/10.1016/S1474-4422(06)70471-9
[2]  Biundo, R., Weis, L. and Antonini, A. (2016) Cognitive Decline in Parkinson’s Disease: The Complex Picture. NPJ Parkinson’s Disease, 2, Article No. 16018.
https://doi.org/10.1038/npjparkd.2016.18
[3]  Weil, R.S., Costantini, A.A. and Schrag, A.E. (2018) Mild Cognitive Impairment in Parkinson’s Disease—What Is It? Current Neurology and Neuroscience Reports, 18, 17.
[4]  Elgh, E., Domellof, M., Linder, J., Edstrom, M., Stenlund, H. and Forsgren, L. (2009) Cognitive Function in Early Parkinson’s Disease: A Population-Based Study. European Journal of Neurology, 16, 1278-1284.
https://doi.org/10.1111/j.1468-1331.2009.02707.x
[5]  Hyde, T. and Fritsch, T. (2011) Assessing Executive Function in Parkinson Disease: The Alternating Names Test. Part I. Reliability, Validity, and Normative Data. Parkinsonism and Related Disorders, 17, 100-105.
https://doi.org/10.1016/j.parkreldis.2010.08.023
[6]  Goldman, J.G. and Litvan, I. (2011) Mild Cognitive Impairment in Parkinson’s Disease. Minerva Medica, 102, 441-459.
[7]  Sabbagh, M.N., Adler, C.H., Lahti, T.J., Connor, D.J., Vedders, L., Peterson, L.K., Beach, T.G., et al. (2009) Parkinson Disease with Dementia: Comparing Patients with and without Alzheimer Pathology. Alzheimer Disease and Associated Disorders, 23, 295-297.
https://doi.org/10.1097/WAD.0b013e31819c5ef4
[8]  Emre, M., Aarsland, D., Brown, R., Burn, D.J., Duyckaerts, C., Mizuno, Y., Broe, G.A., Cummings, J., Dickson, D.W., Gauthier, S., Goldman. J., Goetz, C., Korczyn, A., Lees, A., Levy, R., Litvan, I., McKeith, I., Olanow, W., Poewe, W., Quinn, N., Sampaio, C., Tolosa, E. and Dubois, B. (2007) Clinical Diagnostic Criteria for Dementia Associated with Parkinson’s Disease. Movement Disorders, 22, 1689-1707.
https://doi.org/10.1002/mds.21507
[9]  Litvan, I., Goldman, J.G. and Troster, A.L. (2012) Diagnostic Criteria for Mild Cognitive Impairment in Parkinson’s Disease: Movement Disorder Society Task Force Guidelines. Movement Disorders, 27, 349-356.
[10]  Folstein, M.F., Folstein, S.E. and McHugh, P.R. (1975) Mini-Mental State. Journal of Psychiatric Research, 12, 189-198.
https://doi.org/10.1016/0022-3956(75)90026-6
[11]  Alaoui, F.M., Benabdljlil, M., Boutazout, M., Mouji, F., Agoulmame, M., Rahmani, M., Berremdane, M., Ait Benhaddou, H., Ettahiri, L. and Chekili, T. (2003) Adaptation et validation du Mini-Mental State Examination (MMSE) en Arabe. Revue de Neurologie (Paris), 159, 146.
[12]  Nasreddine, Z.S., Phillips, N.A., Bédirian, V., Charbonneau, S., Whitehead, V., Collin, I. and Chertkow, H. (2005). The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool for Mild Cognitive Impairment. Journal of the American Geriatrics Society, 53, 695-699.
https://doi.org/10.1111/j.1532-5415.2005.53221.x
[13]  Azdad, A., Benabdeljlil, M. and El Alaoui Faris, M. (2018) Standardization and Validation of Montreal Cognitive Assessment (MoCA) in the Moroccan Population. International Journal of Brain and Cognitive Sciences, 7, in press.
[14]  Mattis, D.C. and Pan, C.Y. (1988) Mattis and Pan Reply. Physical Review Letters, 61, 2279-2279.
https://doi.org/10.1103/PhysRevLett.61.2279
[15]  Sanhaji, S., Elargoub, I.., Lemaréchal, C., Benabdeljlil, M. and El Alaoui Faris, M. (2018) Moroccan Version of the Mattis Dementia Rating Scale: The Effects of Age, Education, and Gender. World Journal of Neuroscience, 8, 90-97.
[16]  Raven, J., Raven, J.C. and Court, J.H. (1998) Raven Manual: Section 4, Advanced Progressive Matrices. Oxford Psychologists Press Ltd., Oxford, UK.
[17]  Dubois, B., Slachevsky, A., Litvan, I. and Pillon, B. (2000) The FAB: A Frontal Assessment Battery at Bedside. Neurology, 55, 1621-1626.
https://doi.org/10.1212/WNL.55.11.1621
[18]  Strauss, E., Sherman, E.M.S. and Spreen, O. (2006) A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary. Applied Neuropsychology, 14, 62-63.
[19]  Oumellal, A., El Alaoui Faris, M. and Benabdeljlil, M. (2017) The Trail Making Test in Morocco: Normative Data Stratified by Age and Level of Education. Open Journal of Medical Psychology, 7, 1-12.
https://doi.org/10.4236/ojmp.2018.71001
[20]  Stroop, J.R. (1992) Studies of Interference in Serial Verbal Reactions. Journal of Experimental Psychology, 121, 15-23.
https://doi.org/10.1037/h0054651
[21]  Romann, A.J., Dornelles, S., De Liz Maineri, N., De Mello Rieder, C.R. and Rozenfeld Olchik, M. (2012) Cognitive Assessment Instruments in Parkinson’s Disease Patients Undergoing Deep Brain Stimulation. Dementia & Neuropsychologia, 6, 2-11.
https://doi.org/10.1590/S1980-57642012DN06010002
[22]  Goldman, J.G., Williams-Gray, C., Barker, R.A., Duda, J.E. and Galvin, J.E. (2014) The Spectrum of Cognitive Impairment in Lewy Body Diseases. Movement Disorders, 29, 608-621.
https://doi.org/10.1002/mds.25866
[23]  Verbaan, D., Marinus, J., Visser, M., van Rooden, S.M., Stiggelbout, A.M., Middelkoop, H.A.M. and van Hilten, J.J. (2007) Cognitive Impairment in Parkinson’s Disease. Journal of Neurology, Neurosurgery & Psychiatry, 78, 1182-1187.
https://doi.org/10.1136/jnnp.2006.112367
[24]  Picascia, M., Pozzi, N.G., Todisco, M., Minafra, B., Sinforiani, E., Zangaglia, R., Ceravolo, R. and Pacchetti, C. (2018) Cognitive Disorders in Normal Pressure Hydrocephalus with Initial Parkinsonism in Comparison with de Novo Parkinson’s Disease. European Journal of Neurology..
[25]  Hong, J.Y. and Yun, H.J. (2014) Cognitive and Cortical Thinning Patterns of Subjective Cognitive Decline in Patients with and without Parkinson’s Disease. Parkinsonism and Related Disorders, 20, 999-1003.
https://doi.org/10.1016/j.parkreldis.2014.06.011
[26]  Pigott, K., Rick, J., Xie, S.X., et al. (2015) Longitudinal Study of Normal Cognition in Parkinson Disease. Neurology, 85, 1276-1282.
https://doi.org/10.1212/WNL.0000000000002001
[27]  Marsh, L. (2013) Depression and Parkinson’s Disease: Current Knowledge. Current Neurology and Neuroscience Reports, 13, 409.
https://doi.org/10.1007/s11910-013-0409-5
[28]  Troster, A.I., Stalp, L.D., Paolo, A.M., Fields, J.A. and Koller, W.C. (1995) Neuropsychological Impairment in Parkinson’s Disease with and without Depression. Archives of Neurology, 52, 1164-1169.
https://doi.org/10.1001/archneur.1995.00540360042014
[29]  Lezak, M.D. (1995) Neuropsychological Assessment. 3rd Edition, Oxford University Press, New York.
[30]  Schrag, A., Siddiqui, U.F., Anastasiou, Z., Weintraub, D. and Schott, J.M. (2017). Clinical Variables and Biomarkers in Prediction of Cognitive Impairment in Patients with Newly Diagnosed Parkinson’s Disease: A Cohort Study. The Lancet Neurology, 16, 66-75.
https://doi.org/10.1016/S1474-4422(16)30328-3
[31]  Filippi, M., Elisabetta, S., Piramide, N. and Agosta, F. (2018) Functional MRI in Idiopathic Parkinson’s Disease. International Review of Neurobiology, 141, 439-467.
https://doi.org/10.1016/bs.irn.2018.08.005

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