The aim of this study was to qualitatively described effect of the oxidative stress, neurotransmission change and the neurodegeneration in animal model of chronic intoxication by aluminum. Electrocortical brain activity of animal model of stress and neurodegeneration is comparable with Alzheimer’s Dementia (AD). We used adult animals, during 6 weeks intraperitoneally treated with aluminum. Both animals and patients with Alzheimer’s Dementia have increased relative spectral power in delta range. By fractal analysis we described changes in electrocortical activity of aluminum intoxication animals compare to physiological control. We used change in delta range to calculate fractal dimension for the pathophysiological state of disease. We evaluate effect of stress and neurodegeneration, oxidative stress and accumulation of beta amyloid and neurofibrillary tangles as change in fractal dimension (FD). We conclude that change in fractal dimension could be used for prognosis of AD. Results show that decrease in fractal dimension could be used for evaluation of changes in neural activity in occurrence of AD.
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Marta?, L.J., Kesi?, S., ?uli?, M., Grbi?, G., Spasi?, S., Sekuli?, S. and Lalo?evi?, D. (2006) Effect of Aluminium Neurotoxicity on Rat Brain Activity. Acta Physiologica and Pharmacologica Serbica, 42, 219-225.
Spasic, S., Kalauzi, A., Culic, M., Grbi?, G. and Marta?, L.J. (2005) Estimation of Parameter kmax in Fractal Analysis of Rat Brain Activity. Annals of the New York Academy of Sciences, 1048, 427-429. https://doi.org/10.1196/annals.1342.054
Gupta, V.B., Anltha, S., Hegde., M.L., Zecca, L., Garruto, R.M., Ravid, R., Shankar, K., Stein, R., Shanmugavelu, P. and Rao, K.S.J. (2005) Aluminum in Alzheimer’s Disease: Are We Still at a Crossroad. Cellular and Molecular Life Sciences, 62, 143-158. https://doi.org/10.1007/s00018-004-4317-3