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Serum Lipase in Pulmonary Tuberculosis Patients in Kinshasa—A Hospital Based Study

DOI: 10.4236/jtr.2018.62015, PP. 156-165

Keywords: Pulmonary Tuberculosis, Serum Lipases, Kinshasa

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Context: The increase of serum lipase is established for pancreatic and bile duct disorders. However, the production of this enzyme by other organs, including the lungs, leads to the question of its potential role in the diagnosis of other conditions including lung diseases. Objective: The aim of the present study was to describe the profile of serum lipase in patients who suffered from the pulmonary tuberculosis and to identify its determinants. Patients and methods: A cross-sectional study was performed from July to October 2013 in four hospitals of Kinshasa (The University Hospital of Kinshasa, Lisanga medical Center and 2 medical centers of Save Army). Patients who suffered from tuberculosis were included. The levels of serum lipase, triglyceridemia, cholesterolemia, c-reactive protein were noted, as so as the hemogram profile and the prescribed treatment (category and phase). Results: One hundred and twenty-eight patients suffering from pulmonary tuberculosis were included. Forty three women (33.6%) and 85 men (66.4%). The sex ratio M/F was 1:9. Hyperlipasemia was observed in 44.5% of patients. The average level of serum lipase was 36.6 ± 5.0 IU/L (normal value: ≤ 38 IU/L) in tuberculosis patients and 30 ± 2.3 IU/L in controls The lipid profile of the patients was normal. Conclusion: L Hyperlipasemia can be encountered, in varying proportions, during pulmonary tuberculosis. It would be an indication of inflammation of the pulmonary parenchyma.


[1]  Tietz, N.W. and Shuey, D.F. (1993) Lipase in Serum—The Clisive Enzyme: An Overview. Clinical Chemistry, 38, 1000-1010.
[2]  Destain, J. and Fickers, P. (2007) Lipases Are Typical Hydrolases: Principal Characteristics and Applications. Université de Liège, Centre Wallon de Biologie industrielle, Service de Technologie Microbienne.
[3]  Meyer, J.H. (1989) Pancreatic Physiology. In: Sleisenger, M.H. and Fordtran, J.S., Eds., Gastrointestinal Diseases: Pathology Diagnosis, Management, 4th Edition, W.B. Saunders, Philadelphia, 1777-1787.
[4]  Stem, E.A. and Myers, G.L. (1996) Lipids, Apolipoproteins, and Lipoproteins. In: Tietz, Ed., Fundamental Clinical Chemistry, 4th Edition, W.B. Saunders Company, Philadelphia, 375-401.
[5]  Moss, D.W. and Henderson, A.R. (1994) Enzymes. In: Tietz, Ed., Textbook of Clinical Chemistry, 2nd Edition, W.B Saunders Company, Philadelphia, 735-896.
[6]  Irvine, J.R. and Ramji, S.A. (2002) Lipoprotein Lipase: Structure, Function, Regulation and Role in Disease. Journal of Molecular Medicine, 12, 753-769.
[7]  Heintel, D., Kienle, D., Schehata, M., et al. (2005) High Expression of Lipoprotein Lipase in Poor Risk Bcell Chronic Lymphocyte Leukemia. Journal of Molecular Medicine, 19, 1216-1223.
[8]  Okabe, T., Yorifuji, H., Murase, T. and Takaku, F. (1984) Pulmonary Macrophage: A Major Source of Lipoprotein Lipase in the Lung. Biochemical and Biophysical Research Communications, 125, 273-278.
[9]  Lu, J., Chaoneng, J.L., Yu, W., Xu, Z. and Huang, S. (2008) Expression of Lipoprotein Lipase Associated with Lung Carcinoma Tissue. Molecular Biology Reports, 35, 59-63.
[10]  Greenberger, N.J. and Toskes, P.P. (2002) Pancréatites aigues et chroniques. In: Harrison, Ed., Principes de médecine interne, 15ème édition, Médecine-Sciences Flammarion, 1792-1804.
[11]  Todd, K.B. and Désirée, E.M. (1999) Acute Necrotizing Pancreatitis. The New England Journal of Medicine, 340, 1412-1414.
[12]  Querfeld, L., Ong, J.M., Prehn, J., Crty, J., Saffari, B., Jordan, S.C. and Kern, P.A. (1990) Effects of Cytokines on the Production of Lipoprotein Lipase in Cultured Human Macrophages. The Journal of Lipid Research, 31, 1379-1386.
[13]  Brust, B., Lecoufle, M., Tuaillon, E., Dedieu, L., Canaan, S., Valuerde, V. and Kremer, L. (2011) Mycobacterium Tuberculosis Lipolytic Enzyme as Potential Biomarkers for the Diagnosis of Active Tuberculosis. PLoS One, 6, 25078.
[14]  Drain, P.K., Mayeza, L., Bartman, P., Hurtado, R., Moodley, P., Varghese, S., Maartens, G., Alvarez, G.G. and Wilson, D. (2014) Diagnostic Accuracy and Clinical Role of Rapid C-Reactive Protein Testing in HIV-Infected Individuals with Presumed Tuberculosis in South Africa. The International Journal of Tuberculosis and Lung Disease, 18, 20-26.
[15]  Lee, S.W., Rang, Y.A., Yoon, Y.S., Um, S.W., Lee, S.M., Yoo, C.G., Kim, Y.W., Han, S.K., Shim, Y.S. and YIM, J.J. (2006) The Prevalence and Evolution of Anemia Associated with Tuberculosis. Journal of Korean Medical Science, 21, 1028-3225.


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