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MtsR, an Iron-Dependent Regulator in Streptococcus iniae

DOI: 10.4236/as.2018.95042, PP. 609-618

Keywords: Streptococcus iniae, Iron-Dependent Regulator, Iron Transporter, MtsR, MtsABC

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Abstract:

Streptococcus iniae (S. iniae) is a major pathogen that is capable of resulting severe economic loss to cultured fish. Steadily iron availability from micro-environment is an important virulence factor for pathogens, and S. iniae encodes the iron-transporter MtsABC to accomplish heme utilization, but very little was known about the mechanisms involved in regulating and maintaining iron balance in S. iniae. In this study, the role of a putative iron-dependent transcriptional regulator MtsR was investigated, and the results showed that MtsR regulated the expression of iron-transport mtsABC to control iron homeostasis in S. iniae.

References

[1]  Wooldridge, K.G. and Williams, P.H. (1993) Iron Uptake Mechanisms of Pathogenic Bacteria. FEMS Microbiology Reviews, 12, 325-348.
https://doi.org/10.1111/j.1574-6976.1993.tb00026.x
[2]  Christine, M.L. and Stephen, B.C. (1993) Role of Iron in Regulation of Virulence Genes. Clinical Microbiology Reviews, 6, 137-149.
https://doi.org/10.1128/CMR.6.2.137
[3]  Cyril, A., Tjepkema, J.D. and Trinick, M.J. (1997) Heme Compounds as Iron Sources for Nonpathogenic Rhizobium bacteria. Journal of Bacteriology, 179, 3076-3078.
https://doi.org/10.1128/jb.179.9.3076-3078.1997
[4]  Zou, L.L., Wang, J., Huang, B.F., Xie, M.Q. and Li, A.X. (2010) A Solute-Binding Protein for Iron Transport in Streptococcus iniae. BMC Microbiology, 10, 1-10.
https://doi.org/10.1186/1471-2180-10-309
[5]  Zou, L.L., Wang, J., Huang, B.F., Xie, M.Q. and Li, A.X. (2011) MtsB, A Hydrophobic Membrane Protein of Streptococcus iniae, Is an Effective Subunit Vaccine Candidate. Vaccine, 29, 391-394.
https://doi.org/10.1016/j.vaccine.2010.10.062
[6]  Andrews, S.C., Robinson, A.K. and Rodriguez-Quinones, F. (2003) Bacterial Iron Homeostasis. FEMS Microbiology Reviews, 27, 215-237.
https://doi.org/10.1016/S0168-6445(03)00055-X
[7]  Kitao, T., Aoki, T. and Sakoh, R. (1981) Epizootic Caused by Beta-Haemolytic Streptococcus Species in Cultured Freshwater Fish. Fish Pathology, 15, 301-307.
https://doi.org/10.3147/jsfp.15.301
[8]  Kusuda, R. (1992) Bacterial Fish Diseases in Marineculture in Japan with Special Emphasis on Streptococcosis. The Israeli Journal of Aquaculture, 44, 140.
[9]  Eldar, A., Bejerano, Y. and Bercovier, H. (1994) Streptococcus shiloi and Streptococcus Difficile: Two New Streptococcal Species Causing a Meningoencephalitis in Fish. Current Microbiology, 28, 193-143.
https://doi.org/10.1007/BF01571054
[10]  Eldar, A., Bejerano, Y. and Bercovier, H. (1994) Streptococcus shiloi and Streptococcus Difficile: Two New Streptococcal Species Causing a Meningoencephalitis in Fish. Current Microbiology, 28, 193-143.
https://doi.org/10.1007/BF01571054
[11]  Weinstein, M.R., Litt, M., Kertesz, D.A., Wyper, P., Rose, D., Coulter, M., McGeer, A., Facklam, R., Ostach, C., Willey, B.M., Borczyk, A. and Low, D.E. (1997) Invasive Infections Due to a Fish Pathogen, Streptococcus iniae. S. iniae Study Group. New England Journal of Medicine, 337, 589-594.
https://doi.org/10.1056/NEJM199708283370902
[12]  Zhou, S.M., Xie, M.Q., Zhu, X.Q., Ma, Y., Tan, Z.L. and Li, A.X. (2008) Identification and Genetic Characterization of Streptococcus iniae Strains Isolated from Diseased Fish in China. Journal of Fish Diseases, 31, 869-875.
https://doi.org/10.1111/j.1365-2761.2008.00954.x
[13]  Zehava, E., Eric, M., Stephen, A.M. and June, R.S. (1996) Acquisition of Iron Host Protein Proteins by Group A Streptococcus. Infection and Immunity, 64, 5428-5429.
[14]  Shelly, B., Jeffrey, D.F., Darrin, J.B. and Joyce, C.S.A. (2007). The Two-Component System sivS/R Regulates Virulence in Streptococcus iniae. FEMS Immunology & Medical Microbiology, 51, 547-554.
https://doi.org/10.1111/j.1574-695X.2007.00334.x
[15]  Kammler, M., Schon, C. and Hantke, K. (1993) Characterization of the Ferrous Iron Uptake System of Escherichia coli. Journal of Bacteriology, 175, 6212-6219.
https://doi.org/10.1128/jb.175.19.6212-6219.1993
[16]  Laurent, M., Lzabela, S., Nicole, M.G. and James, M.M. (2008) Remodeling of the Streptococcus agalactiae Transcription in Response to Growth Temperature. PLoS ONE, 3, 2785-2796.
https://doi.org/10.1371/journal.pone.0002785

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