MRI is frequently applied to lateralizelanguage
in pre-surgical planning, with potentialto localize
functionally important cortex too.Here we present BOLD signal activation
maps and related functional connectivity, in response to three commonly administered
fMRI language tasks. Methods: Datasets from 55 pre-surgical fMRI studies
were analyzed. Verbal response naming, covert word generation and passive listening
tasks were administered in all studies. Single-subject analyses, group analyses
and region-of-interest analyses were conducted, and a multi-subject functional connectivity
analysis was performed. Results: Single-subject analyses revealed thatclinicallyimportantlanguage regions were activated
in all but three patients using the panel of tasks. Group analyses revealedsignificant bilateral BOLD signal increases inanterior
and posteriorlanguage regionsin response
to verbal response naming and bilateral signal increase in posterior language regions
only in response to passive listening. Covert word generationactivated anterior language regions bilaterally and posterior language cortexin the dominant hemisphere. Functional
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