All Title Author
Keywords Abstract


User Experience of ColdZyme Mouth Spray against Common Cold in Competitive Athletes

DOI: 10.4236/ojrd.2018.82002, PP. 13-20

Keywords: Common Cold, Athletes, ColdZyme?, Mouth Spray

Full-Text   Cite this paper   Add to My Lib

Abstract:

ColdZyme Mouth Spray (ColdZyme) is intended to reduce the probability of catching a cold and/or can help shorten the duration of a cold, if used at an early stage of the infection, by forming a barrier on the pharyngeal mucous membrane. The user experience of ColdZyme on naturally occurring common cold infections was evaluated in competitive athletes training professionally or on an amateur level. Thirteen athletes completed weekly electronic surveys on occurrence of common colds, cold severity and user experience over the course of 3 months. The 13 participants reported in total 15 cold incidents with an average duration of 7.4 days. The average cold severity was 31.2 on a visual-analogue scale (VAS) ranging from 0 (mildest possible cold) to 100 (worst possible cold). The overall user satisfaction with ColdZyme was high. 81% of the reported colds were experienced to be milder and/or shorter than usual. None of the participants reported “No effect”. Out of the participants who reported absence of a cold in the previous week, 69% reported a positive answer to the question if ColdZyme had prevented them from catching a cold in the previous week. Conclusion: The present study evaluated prevention and alleviation of naturally occurring common cold in athletes, and demonstrated that ColdZyme may be an easy and practical way for competitive athletes to prevent or reduce infections of the common cold virus and corresponding unwanted absence from training and competition. Due to the lack of a comparator group, a placebo effect cannot be excluded.

References

[1]  Spence, L., Brown W., Pyne, D., Nissen, M., Sloots, T., Mccormack, J., Locke, S. and A Fricker, P. (2007) Incidence, Etiology, and Symptomatology of Upper Respiratory Illness in Elite Athletes. Medicine and Science in Sports and Exercise, 39, 577-586.
https://doi.org/10.1249/mss.0b013e31802e851a
[2]  Gleeson, M. and Pyne, D. (2016) Respiratory Inflammation and Infections in High-Performance Athletes. Immunology and Cell Biology, 94, 124-131.
https://doi.org/10.1038/icb.2015.100
[3]  Walsh, N. and Oliver, S. (2016) Exercise, Immune Function and Respiratory Infection: An Update on the Influence of Training and Environmental Stress. Immunology and Cell Biology, 94, 132-139.
https://doi.org/10.1038/icb.2015.99
[4]  Nieman, D. (1994) Exercise, Infection, and Immunity. International Journal of Sports Medicine, 15, S131-S141.
https://doi.org/10.1055/s-2007-1021128
[5]  Gleeson, M. (2007) Immune Function in Sport and Exercise. Journal of Applied Physiology, 103, 693-699.
https://doi.org/10.1152/japplphysiol.00008.2007
[6]  Schwellnus, M., et al. (2016) How Much Is Too Much? (Part 2) International Olympic Committee Consensus Statement on Load in Sport and Risk of Illness. British Journal of Sports Medicine, 50, 1043-1052.
https://doi.org/10.1136/bjsports-2016-096572
[7]  Alonso, J., et al. (2012) Determination of Future Prevention Strategies in Elite Track and Field: Analysis of Daegu 2011 IAAF Championships Injuries and Illnesses Surveillance. British Journal of Sports Medicine, 46, 505-514.
https://doi.org/10.1136/bjsports-2012-091008
[8]  Kemmerer, T.P., Cetron, M., Harper, L. and Kozarsky, P.E. (1998) Health Problems of Corporate Travelers: Risk Factors and Management. Journal of Travel Medicine, 5, 184-187.
https://doi.org/10.1111/j.1708-8305.1998.tb00504.x
[9]  Vareille, M., Kieninger, E. and Edwards, M.R. (2011) The Airway Epithelium: Soldier in the Fight against Respiratory virusEs. Clinical Microbiology Reviews, 24, 210-229.
https://doi.org/10.1128/CMR.00014-10
[10]  Clarsund, M., Fornbacke, M., Uller, L., Johnston, S. and Emanuelsson, C. (2017) A Randomized, Double-Blind, Placebo-Controlled Pilot Clinical Study on ColdZyme® Mouth Spray against Rhinovirus-Induced Common Cold. Open Journal of Respiratory Diseases, 7, 125-135.
https://doi.org/10.4236/ojrd.2017.74013
[11]  Rousse, M., Cucuat, N., Janicot, C. and Shrivastava, R. (2014) Innovative Scientific Concept of Topical Virus Glycoprotein Inhibitors Incorporated in Hyperosmotic Glycerol Revolutionizes Future Prospects in the Treatment of Viral and Bacterial Throat Infections. International Journal of Pharmaceutical Sciences and Drug Research, 6, 1-11
[12]  Stefansson, B., Gudmundsdottir, A. and Clarsund, M. (2017) A Medical Device Forming a Protective Barrier That Deactivates Four Major Common Cold Viruses. Virology Research Reviews, 5.
[13]  Jackson, G., Dowling, H., Spiesman, I. and Boand A. (1958) Transmission of the Common Cold to Volunteers under Controlled Conditions. AMA Archives of Internal Medicine, 101, 267-278.
https://doi.org/10.1001/archinte.1958.00260140099015
[14]  Asch, D., Jedrziewski, K. and Christakis, N. (1997) Response Rates to Mail Surveys Published in Medical Journals. Journal of Clinical Epidemiology, 50, 1129-1136.
https://doi.org/10.1016/S0895-4356(97)00126-1
[15]  Allan, G.M. and Arroll, B. (2014) Prevention and Treatment of the Common Cold: Making Sense of the Evidence. CMAJ: Canadian Medical Association Journal, 186, 190-199.
https://doi.org/10.1503/cmaj.121442
[16]  Moreira, A., Delgado, L., Moreira, P. and Haahtela, T. (2009) Does Exercise Increase the Risk of Upper Respiratory Tract Infections? British Medical Bulletin, 90, 111-131.
https://doi.org/10.1093/bmb/ldp010
[17]  Informed Health Online, Common Cold Overview. PubMed Health.
https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0072727/#i2642.sources
[18]  Clarsund, M. (2017) Evaluation of ColdZyme Mouth Spray for the Protection against Common Cold in Elite Athletes to Reduce Unwanted Absence from Training and Competition. Open Journal of Respiratory Diseases, 7, 103.
https://doi.org/10.4236/ojrd.2017.73010

Full-Text

comments powered by Disqus