The Triple Negative “Basal-like”
breast cancer (TNBL) tumours have a high proliferative
capacity and develop a resistance phenotype associated with metastases. However, the management of TNBL
carcinomas is still not standardized. Among
the promising trails, gold nanoparticles could be a relevant tool for the
development of a targeted treatment for this breast cancer subtype in
monotherapy, associated and/or conjugated with other drugs. In this work, we
report the cytotoxicity impact of gold nanoparticles wrapped in Poly-Ethylene
Glycol (PEG) on the TNBL HCC-1937 breast cancer cell line. PEG-coated gold nanoparticles (PEG-Au NPs) were
synthesized by a two-stepmethod using
a reduction process followed by a post-functionalization called PEGylation.
PEG-Au NPs were characterized using transmission electron microscopy
and X-ray diffraction. The gold content of the samples was determined
using atomic absorption spectrometer. The cytotoxicity tests were performed using Sulforhodamine B survival test
and resazurin viability test. PEG-Au NPs impact analysis on HCC1937 TNBL cell
line showed a clear toxic action of type dose dependent and at long term. These
PEGylated gold nanoparticles present a promising tool for the development of
tumor-specific radiosensitizing vectors, with or without the association
of other treatment strategies.
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