The common cold is one of the most frequently encountered infectious diseases
in humans and, despite the modest severity in most cases; it presents a
significant economic burden upon society and individuals. ColdZyme？ Mouth
Spray (ColdZyme？, Enzymatica AB, Lund, Sweden) is a mouth spray intended
to reduce the probability of catching a cold and can also help shorten the duration
of a cold if used at an early stage of the infection, by forming a barrier
on the oropharyngeal mucous membrane. This study evaluated the effect of
ColdZyme？ on common cold related sick-leave in preschool (kindergarten)
staff. Fifteen preschool staff members were evaluated over a 6-month period
and ColdZyme？ was used according to instructions. Sick-leave days were recorded
and compared to historical data. The number of average sick leave days
decreased during the period from 7.4 days to 4.1 days (p = 0.04). It is notable
that, if occurring, the majority of subjects perceived a common cold infection
as milder than usual. Conclusion: Using ColdZyme？ to apply a barrier to the
pharyngeal mucous membrane may be an easy and practical way to prevent or
reduce infections and corresponding sick leave in personnel from the preschool
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