Research reports on pulmonary function measurements often mention caffeine abstinence as a condition for testing subjects. Yet, the effects of caffeine on respiration are not well documented. This study was intended to investigate the physiological effects of caffeine on respiratory resistance measurements and the necessity of caffeine avoidance in such testing. Thirty-one subjects were administered caffeine in pill form for dosages in the range of 3 - 4.5 mg/kg body weight. Respiratory resistance was measured with the Airflow Perturbation Device every 15 minutes after caffeine ingestion until a full hour of elapsed time. No changes were noted in inhalation, exhalation, and average respiratory resistances during the times of measurements. The conclusion is that for low dosages of caffeine, respiratory resistance measurements are not affected by caffeine ingestion prior to testing.
References
[1]
Daly, J.W., Ukena, D. and Jacobson, K.A. (1987) Analogues of Adenosine, Theophylline, and Caffeine: Selective Interactions with A, and A2 Adenosine Receptors. In: Gerlach, E. and Becker, B.F., Eds., Topics and Perspectives in Adenosine Research, Springer, Berlin, 23-36. https://doi.org/10.1007/978-3-642-45619-0_3
[2]
Neims, A.H. and Von Borstel, R.W. (1983) Caffeine: Metabolism and Biochemical Mechanisms of Action. In: Wurtman, R.J. and Wurtman, J.J., Eds., Nutrition and the Brain, Raven Press, New York, l-30.
[3]
Boulenger, J.P., Patel, J. and Marangos, P.J. (1982) Effects of Caffeine and Theophylline on Adenosine and Benzodiazepine Receptors in Human Brain. Neuroscience Letters, 30, 161-166. https://doi.org/10.1016/0304-3940(82)90290-7
[4]
Dews, P.B. (1984) Behavioral Effects of Caffeine. In: Dews, P.B., Ed., Caffeine: Perspectives from Recent Research, Springer, Heidelberg, 86-103.
https://doi.org/10.1007/978-3-642-69823-1_6
[5]
Robertson, D., Wade, D., Workman, R., Woosley. R.I., and Oates, J.A. (1981) Tolerance to the Humoral and Hemodynamic Effects of Caffeine in Man. Journal of Clinical Investigation, 67, 1111-1117. https://doi.org/10.1172/JCI110124
[6]
Mohsenin, A. and Blackburn, M.R. (2006) Adenosine Signaling in Asthma and Chronic Obstructive Pulmonary Disease. Current Opinion in Pulmonary Medicine, 12, 54-59. https://doi.org/10.1097/01.mcp.0000199002.46038.cb
[7]
Mitchell, P.J. and Redman, J.R. (1992) Effects of Caffeine, Time of Day and User History on Study-Related Performance. Psychopharmacology, 109, 121-126.
https://doi.org/10.1007/BF02245489
[8]
Pasman, W.J., Van Baak, M.A., Jeukendrup, A.E. and De Haan, A. (1995) The Effect of Different Dosages of Caffeine on Endurance Performance Time. International Journal of Sports Medicine, 16, 225-230.https://doi.org/10.1055/s-2007-972996
[9]
Lieberman, H.R., Wurtman, R.J., Emde, G.G., Roberts, C. and Coviella, I.L.G. (1987) The Effects of Low Doses of Caffeine on Human Performance and Mood. Psychopharmacology, 92, 308-312. https://doi.org/10.1007/BF00210835
[10]
Bell, D.G., Jacobs, I. and Zamecnik, J. (1998) Effects of Caffeine, Ephedrine and their Combination on Time to Exhaustion during High-Intensity Exercise. European Journal of Applied Physiology and Occupational Physiology, 77, 427-433.
https://doi.org/10.1007/s004210050355
[11]
Astrup, A., Toubro, S., Cannon, S., Hein, P. and Madsen, J. (1991) Thermogenic Synergism between Ephedrine and Caffeine in Healthy Volunteers: A Double-Blind, Placebo-Controlled Study. Metabolism, 40, 323-329.
https://doi.org/10.1016/0026-0495(91)90117-F
[12]
Lausted, C.G., and Johnson, A.T. (1999) Respiratory Resistance Measured by an Airflow Perturbation Device. Physiological Measurement, 20, 21-35.
https://doi.org/10.1088/0967-3334/20/1/002
[13]
Silverman, N.K. and Johnson, A.T. (2005) Design for a Stand-Alone Airflow Perturbation Device. Journal of Medical Implants and Surgery, 1, 139-148.
[14]
Zahn, T.P. and Rapoport, J.L. (1987) Autonomic Nervouse System Effects of Acute Doses of Caffeine in Caffeine Users and Abstainers. International Journal of Psychophysiology, 5, 33-41. https://doi.org/10.1016/0167-8760(87)90070-5
[15]
Harder, S., Staib, A.H., Beer, C., Papenburg, A., Stille, W. and Shah, P.M. (1988) 4-Quinolones Inhibit Biotransformation of Caffeine. European Journal of Clinical Pharmacology, 35, 651-656. https://doi.org/10.1007/BF00637602
[16]
Johnson, A.T., Jones, S.C., Pan, J.J. and Vossoughi, J. (2012) Variation of Respiratory Resistance Suggests Optimization of Airway Caliber. IEEE Transactions on Biomedical Engineering, 59, 2355-2361.
https://doi.org/10.1109/TBME.2012.2204055
