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Late Commencement of Anti-Tuberculosis Drugs in Three Directly Observed Treatment Short Course Centres in Benue State Nigeria: A Neglected Correlate of Tuberculosis Management

DOI: 10.4236/jtr.2017.52011, PP. 95-105

Keywords: Tuberculosis, Treatment, Late Commencement, Outcomes

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Abstract:

Background: Most researches on the correlate of Tuberculosis (TB) treatment outcomes place emphasis on sociodemographic characteristics of the patients, Human Immunodeficiency Virus status and CD4+ count of patients and nutrition among others. This study assessed the effect of delay in commencement of anti-TB regimen on the treatment outcomes of all Tuberculosis patients treated between 2011 and 2014 in three directly observed treatment short course centres in Benue State, Nigeria. Methodology: A retrospective cohort study with convenient sampling technique was used for all registered Tuberculosis patients enrolled for treatment within the reviewed period. Chi-square (χ2) test was used for test of association between the independent variables and the main outcomes of the study, with statistical significance set at p-value of 5%. Results: Of the total 1711 cases reviewed, the males to females ratio was 3.9:1. The mean age for the males’ patients was 39.0 ± 15.3 years and the females 33.7 ± 14.2 years. Majority of the patients were new pulmonary Tuberculosis cases and they commenced their treatment after 3 weeks of diagnosis. Higher failure and death rate were reported amongst the patients who commenced their treatment late (78.7% and 42.5% respectively). The relationship between the treatment outcome and the time of commencement of anti-TB drug regimen was statistically significant (p < 0.005). Conclusions: Commencement of anti-TB drugs in all diagnosed Tuberculosis patients is an important correlate that must be addressed in order to achieve the global goal of reducing Tuberculosis prevalence to the level at which it will no longer constitute a public health problem in Nigeria.

References

[1]  FMOH Nigeria, Department of Public Health (2010) National Tuberculosis and Leprosy Control Programme. Revised 5th Edition, Workers Manual.
[2]  WHO (2013) Systematic Screening for Active Tuberculosis: Principles and Recommendations. WHO, Geneva, Switzerland, WHO/HTM/TB/2013.
http://www.who.int/tb/publications/tbscreening
[3]  FMOH. First National Tuberculosis Prevalence Survey, 2012, Nigeria.
[4]  Ofor, M.O. and Ofole, M.N. (2014) The Millennium Development Goals in Nigeria: An Assessment of the Journey So Far. Researcher, 6, 81-90.
http://www.sciencepub.net/researcher
[5]  Bertie, S., Emmanuel, Margaret, C. and Rachael, F. (2003) Briefing Paper on Benue TB Control Pilot: A Public-Private Initiative Integrated with Primary Health Care. Liverpool Associates in Tropical Health, 2003, Number 7.
[6]  MOH. Benue State, Nigeria. Tuberculosis and Leprosy Control Programme Annual Report, 2014.
[7]  Akaninyene, A.O. (2013) A Review of the National Tuberculosis and Leprosy Control Programme (ntblcp) of Nigeria: Challenges and Prospects. Annals of Tropical Medicine and Public Health, 6, 491-500.
[8]  WHO. Global Tuberculosis Control Report (2015) 20th Edition, WHO, Geneva.
[9]  United State Embassy in Nigeria (2012) Nigeria Tuberculosis Fact Sheet.
http://nigeria.usembassy.gov
[10]  WHO (2013) Global Tuberculosis Report, 2013. WHO, Geneva.
[11]  Mekdes, K.G., Gunnar, A.B. and Jan, C.F. (2010) Barriers and Facilitators of Adherence to Tuberculosis Treatment in Patients on Concomitant TB and HIV Treatment: A Qualitative Study. BMC Public Health, 10, 651.
[12]  Protocol Health Service Directive Queensland (2014) Protocol for Treatment of Tuberculosis. Protocol QH-HSDPTL-040-3: 2013.
[13]  Luka, M.I, Idris, S.H., Patrick, N., Raymond, D., Ndadilnasiya, E.W, Moses, O.A., et al. (2014) Factors Associated with Interruption of Treatment among Pulmonary Tuberculosis Patients in Plateau State, Nigeria. The Pan African Medical Journal, 17, 78.
[14]  Jaiswal, A., Singh, V., Ogden, J.A. and Porter, J.D.H. (2003) Adherence to Tuberculosis Treatment: Lesson from the Urban Setting of Delhi, India. Tropical Medicine and International Health, 8, 625-633.
https://doi.org/10.1046/j.1365-3156.2003.01061.x
[15]  Emal, M., Tarekegne, D., Atanaw, T., Ebabu, A. and Endris, M. (2015) Treatment Outcomes of Tuberculosis Patients in Metema Hospital, Northwest Ethiopia: A Four Years Retrospective Study. Mycobacterial Diseases, 5, 190.
https://doi.org/10.4172/2161-1068.1000190
[16]  Olarewaju, S., Olanrewaju, O., Folorunso, E., Babatunde, A., Temitayo-Oboh, A., Abdulsalam, S., et.al. (2014) Treatment Outcome of Tuberculosis Patients Registered at DOTS Centre in Ogbomoso, Southwestern Nigeria: A 4-Year Retrospective Study. Tuberculosis Research and Treatment, 2014, Article ID: 201705.
https://doi.org/10.1155/2014/201705
[17]  Egbewale, B.E., Taiwo, S.S., Odu, O.O., Olowu, O.A. and Sobaloju, S.O. (2007) Tuberculosis Treatment Outcomes in State Hospital, Osogbo, Southwestern Nigeria: A 4 Year Review. Nigerian Journal of Medicine, 16, 148-154. https://doi.org/10.4314/njm.v16i2.37298
[18]  Gninafon, M., Tawo, L. and Kassa, F. (2004) Outcome of Tuberculosis Retreatment in Routine Conditions in Cotonou, Benin. International Journal of Tuberculosis and Lung Disease, 8, 1242-1247.
[19]  National Population Commission (2010) National Population Commission. Report on the 2006 Census Result. Federal Republic of Nigeria Official Gazette, Abuja, B24.
[20]  Nigeria FMOH (2009) National Tuberculosis and Leprosy Control Programme: Annual Report 2008. FMOH, Abuja.
[21]  Dim, C.C. and Dim, N.R. (2013) Trends of Tuberculosis Prevalence and Treatment Outcome in an Under-Resourced Setting: The Case of Enugu State, South East Nigeria. Nigerian Medical Journal, 45, 392-397.
https://doi.org/10.4103/0300-1652.126292
[22]  Kingsley, C.O. (2014) A Review of Community TB Care Intervention in Nigeria-A Care Study of Ngo Intervention—A Capstone Project. South American Journal of Public Health, 2, 1.
[23]  Dye, C. (2008) Epidemiology. In: Davies, P.D., Barnes, P.F. and Gordon, S.B., Eds., Clinical Tuberculosis, 4th Edition, Hodder and Stoughton Ltd., London, 21-44.
https://doi.org/10.1201/b13468-4
[24]  WHO (2009) Global Tuberculosis Control: Epidemiology, Strategy, Financing: WHO Report 2009.
[25]  Ukwaja, K., Alobu, I., Ifebunandu, N., Osakwe, C. and Igwenyi, C. (2011) From DOTS to the Stop TB Strategy: DOTS Coverage and Trend of Tuberculosis Notification in Ebonyi State, Southeastern Nigeria, 1998-2009. The Pan African Medical Journal, 9, 12.
https://doi.org/10.4314/pamj.v9i1.71187
[26]  Gidado, M. (2015) Nigerian Tuberculosis Programme, Journey So Far. Paper Presented at Post 2015 Journalist Seminar, Copenhagen Consensus Center, Tewksbury.

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