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Review on Exercise and Mitochondrial Dynamics

DOI: 10.12677/APS.2016.42007, PP. 39-44

Keywords: 运动,线粒体融合/分裂,线粒体自噬
, Mitochondrial Fusion/Fission, Mitophagy

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Mitochondrial dynamics is closely related to mitochondrial quality control. The effect of exercise on mitochondrial dynamics directly influences mitochondrial quality control. This paper reviewed the mechanism of mitochondrial dynamics and its relationship with exercise.


[1]  Dorn 2nd, G.W. and Kitsis, R.N. (2015) The Mitochondrial Dynamism-Mitophagy-Cell Death Interactome: Multiple Roles Performed by Members of a Mitochondrial Molecular Ensemble. Circulation Research, 116, 167-182.
[2]  Suliman, H.B. and Piantadosi, C.A. (2016) Mitochondrial Quality Control as a Therapeutic Target. Pharmacological Reviews, 68, 20-48.
[3]  Youle, R.J. and van der Bliek, A.M. (2012) Mitochondrial Fission, Fusion, and Stress. Science, 337, 1062-1065.
[4]  Chan, D.C. (2012) Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health. Annual Review of Genetics, 46, 265-287.
[5]  Iqbal, S. and Hood, D.A. (2015) The Role of Mitochondrial Fusion and Fission in Skeletal Muscle Function and Dysfunction. Frontiers in Bioscience (Landmark Ed), 20, 157-172.
[6]  Chen, H., Detmer, S.A., Ewald, A.J., Griffin, E.E., Fraser, S.E. and Chan, D.C. (2003) Mitofusins Mfn1 and Mfn2 Coordinately Regulate Mitochondrial Fusion and Are Essential for Embryonic Development. The Journal of Cell Biology, 160, 189-200.
[7]  Cai, Q. and Tammineni, P. (2016) Alterations in Mitochondrial Quality Control in Alzheimer’s Disease. Frontiers in Cellular Neuroscience, 10, 24.
[8]  Held, N.M. and Houtkooper, R.H. (2015) Mitochondrial Quality Control Pathways as Determinants of Metabolic Health. BioEssays, 37, 867-876.
[9]  Frohman, M.A. (2015) Role of Mitochondrial Lipids in Guiding Fission and Fusion. Journal of Molecular Medicine (Berl), 93, 263-269.
[10]  Chen, Y., Liu, Y. and Dorn 2nd, G.W. (2011) Mitochondrial Fusion Is Essential for Organelle Function and Cardiac Homeostasis. Circulation Research, 109, 1327-1331.
[11]  Papanicolaou, K.N., Kikuchi, R., Ngoh, G.A., et al. (2012) Mitofusins 1 and 2 Are Essential for Postnatal Metabolic Remodeling in Heart. Circulation Research, 111, 1012-1026.
[12]  Gomes, L.C., Di, B.G. and Scorrano, L. (2011) During Autophagy Mitochondria Elongate, Are Spared from Degradation and Sustain cell Viability. Nature Cell Biology, 13, 589-598.
[13]  Bhandari, P., Song, M., Chen, Y., Burelle, Y. and Dorn 2nd, G.W. (2014) Mitochondrial Contagion Induced by Parkin Deficiency in Drosophila Hearts and Its Containment by Suppressing Mitofusin. Circulation Research, 114, 257-265.
[14]  Smirnova, E., Griparic, L., Shurland, D.L. and van der Bliek, A.M. (2001) Dynamin-Related Protein Drp1 Is Required for Mitochondrial Division in Mammalian Cells. Molecular Biology of the Cell, 12, 2245-2256.
[15]  Twig, G., Elorza, A., Molina, A.J., et al. (2008) Fission and Selective Fusion Govern Mitochondrial Segregation and Elimination by Autophagy. The EMBO Journal, 27, 433-446.
[16]  Ong, S.B., Subrayan, S., Lim, S.Y., Yellon, D.M., Davidson, S.M. and Hausenloy, D.J. (2010) Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury. Circulation, 121, 2012-2022.
[17]  Cobley, J.N., Moult, P.R., Burniston, J.G., Morton, J.P. and Close, G.L. (2015) Exercise Improves Mitochondrial and Redox-Regulated Stress Responses in the Elderly: Better Late than Never. Biogerontology, 16, 249-264.
[18]  Drake, J.C., Wilson, R.J. and Yan, Z. (2016) Molecular Mechanisms for Mitochondrial Adaptation to Exercise Training in Skeletal Muscle. The FASEB Journal, 30, 13-22.
[19]  Yan, Z., Lira, V.A. and Greene, N.P. (2012) Exercise Training-Induced Regulation of Mitochondrial Quality. Exercise and Sport Sciences Reviews, 40, 159-164.
[20]  Perry, C.G., Lally, J., Holloway, G.P., Heigenhauser, G.J., Bonen, A. and Spriet, L.L. (2010) Repeated Transient mRNA Bursts Precede Increases in Transcriptional and Mitochondrial Proteins during Training in Human Skeletal Muscle. The Journal of Physiology, 588, 4795-4810.
[21]  Ding, H., Jiang, N., Liu, H., et al. (2010) Response of Mitochondrial Fusion and Fission Protein Gene Expression to Exercise in Rat Skeletal Muscle. Biochimica et Biophysica Acta (BBA)-General Subjects, 1800, 250-256.
[22]  Cartoni, R., Leger, B., Hock, M.B., et al. (2005) Mitofusins 1/2 and ERRα Expression Are Increased in Human Skeletal Muscle after Physical Exercise. The Journal of Physiology, 567, 349-358.
[23]  刘慧君, 姜宁, 赵斐, 等. 急性运动中骨骼肌线粒体移动相关基因表达与线粒体动力学的关系[J]. 天津体育学院学报, 2010, 25(2): 118-121.
[24]  马国栋, 刘艳环. 耐力训练对急性酒精性肝损伤大鼠线粒体融合与分裂的影响[J]. 北京体育大学学报, 2013(11): 70-74.
[25]  Goncalves, I.O., Passos, E., Diogo, C.V., et al. (2016) Exercise Mitigates Mitochondrial Permeability Transition Pore and Quality Control Mechanisms Alterations in Nonalcoholic Steatohepatitis. Applied Physiology, Nutrition, and Metabolism, 41, 298-306.
[26]  Greene, N.P., Lee, D.E., Brown, J.L., et al. (2015) Mitochondrial Quality Control, Promoted by PGC-1α, Is Dysregulated by Western Diet-Induced Obesity and Partially Restored by Moderate Physical Activity in Mice. Physiological Reports, 3, pii: e12470.
[27]  Garnier, A., Fortin, D., Zoll, J., et al. (2005) Coordinated Changes in Mitochondrial Function and Biogenesis in Healthy and Diseased Human Skeletal Muscle. The FASEB Journal, 19, 43-52.
[28]  Liu, L., Sakakibara, K., Chen, Q. and Okamoto, K. (2014) Recep-tor-Mediated Mitophagy in Yeast and Mammalian Systems. Cell Research, 24, 787-795.
[29]  Jin, S.M., Lazarou, M., Wang, C., Kane, L.A., Narendra, D.P. and Youle, R.J. (2010) Mitochondrial Membrane Potential Regulates PINK1 Import and Proteolytic Destabilization by PARL. The Journal of Cell Biology, 191, 933-942.
[30]  Jin, S.M. and Youle, R.J. (2013) The Accumulation of Misfolded Proteins in the Mitochondrial Matrix Is Sensed by PINK1 to Induce PARK2/Parkin-Mediated Mitophagy of Polarized Mitochondria. Autophagy, 9, 1750-1757.
[31]  Wang, X., Winter, D., Ashrafi, G., et al. (2011) PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility. Cell, 147, 893-906.
[32]  Kim, Y., Park, J., Kim, S., et al. (2008) PINK1 Controls Mitochondrial Localization of Parkin through Direct Phosphorylation. Biochemical and Biophysical Research Communications, 377, 975-980.
[33]  Chen, Y. and Dorn 2nd, G.W. (2013) PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria. Science, 340, 471-475.
[34]  Novak, I., Kirkin, V., McEwan, D.G., et al. (2010) Nix Is a Selective Autophagy Receptor for Mitochondrial Clearance. EMBO Reports, 11, 45-51.
[35]  Lee, Y., Lee, H.Y., Hanna, R.A. and Gustafsson, A.B. (2011) Mitochondrial Autophagy by Bnip3 Involves Drp1-Me- diated Mitochondrial Fission and Recruitment of Parkin in Cardiac Myocytes. American Journal of Physiology-Heart and Circulatory Physiology, 301, H1924-H1931.
[36]  Liu, L., Feng, D., Chen, G., et al. (2012) Mitochondrial Outer-Membrane Protein FUNDC1 Mediates Hypoxia-Induced Mitophagy in Mammalian Cells. Nature Cell Biology, 14, 177-185.
[37]  Chen, G., Han, Z., Feng, D., et al. (2014) A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated Mitophagy. Molecular Cell, 54, 362-377.
[38]  Wu, H., Xue, D., Chen, G., et al. (2014) The BCL2L1 and PGAM5 Axis Defines Hypoxia-Induced Receptor-Mediated Mitophagy. Autophagy, 10, 1712-1725.
[39]  Gong, G., Hu, L., Liu, Y., et al. (2014) Upregulation of HIF-1α Protein Induces Mitochondrial Autophagy in Primary Cortical Cell Cultures through the Inhibition of the mTOR Pathway. International Journal of Molecular Medicine, 34, 1133-1140.
[40]  Ishihara, M., Urushido, M., Hamada, K., et al. (2013) Sestrin-2 and BNIP3 Regulate Autophagy and Mitophagy in Renal Tubular Cells in Acute Kidney Injury. American Journal of Physiology-Renal Physiology, 305, F495-F509.
[41]  Di, S.G., Pestell, T.G., Casimiro, M.C., et al. (2015) Loss of Sirt1 Promotes Prostatic Intraepithelial Neoplasia, Reduces Mitophagy, and Delays Park2 Translocation to Mitochondria. The American Journal of Pathology Home, 185, 266-279.
[42]  Jang, S.Y., Kang, H.T. and Hwang, E.S. (2012) Nicotinamide-Induced Mitophagy: Event Mediated by High NAD+/ NADH Ratio and SIRT1 Protein Activation. The Journal of Biological Chemistry, 287, 19304-19314.
[43]  Hariharan, N., Maejima, Y., Nakae, J., Paik, J., DePinho, R.A. and Sadoshima, J. (2010) Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes. Circulation Research, 107, 1470-1482.
[44]  Kume, S., Uzu, T., Horiike, K., et al. (2010) Calorie Restriction Enhances Cell Adaptation to Hypoxia through Sirt1- Dependent Mitochondrial Autophagy in Mouse Aged Kidney. Journal of Clinical Investigation, 120, 1043-1055.
[45]  He, C., Bassik, M.C., Moresi, V., et al. (2012) Exercise-Induced BCL2-Regulated Autophagy Is Required for Muscle Glucose Homeostasis. Nature, 481, 511-515.
[46]  Garber, K. (2012) Autophagy. Explaining Exercise. Science, 335, 281.
[47]  Ma, G.D., Liu, Y.H., Zhang, Q.L., et al. (2014) Pre-Endurance Training Prevents Acute Alcoholic Liver Injury in Rats through the Regulation of Damaged Mitochondria Accumulation and Mitophagy Balance. Hepatology International, 8, 425-435.
[48]  Kim, Y.A., Kim, Y.S., Oh, S.L., Kim, H.J. and Song, W. (2013) Autophagic Response to Exercise Training in Skeletal Muscle with Age. Journal of Physiology and Biochemistry, 69, 697-705.
[49]  薄海, 李玲, 段富强, 朱江. 低氧联合运动对大鼠骨骼肌线粒体自噬的影响[J]. 中国康复医学杂志, 2014, 29(10): 908-912.
[50]  崔迪, 贺杰, 孙婧瑜, 丁树哲. 耐力训练与p53抑制剂pft-α对小鼠骨骼肌线粒体自噬相关基因表达的影响[J]. 天津体育学院学报, 2013, 28(5): 422-426.


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