All Title Author
Keywords Abstract

A Simulation Study on the Specific Loss Power in Magnetic Hyperthermia in the Presence of a Static Magnetic Field

DOI: 10.4236/ojapps.2016.612073, PP. 839-851

Keywords: Magnetic Hyperthermia, Magnetic Nanoparticle, Specific Loss Power, Alternating Magnetic Field, Static Magnetic Field, Magnetization Relaxation, Field-Free Point

Full-Text   Cite this paper   Add to My Lib


Our purpose in this study was to present a method for estimating the specific loss power (SLP) in magnetic hyperthermia in the presence of an external static magnetic field (SMF) and to investigate the SLP values estimated by this method under various diameters (D) of magnetic nanoparticles (MNPs) and amplitudes (H0) and frequencies (f) of an alternating magnetic field (AMF). In our method, the SLP was calculated by solving the magnetization relaxation equation of Shliomis numerically, in which the magnetic field strength at time t (H(t)) was assumed to be given by \"\", with Hs being the strength of the SMF. We also investigated the SLP values in the case when the SMF with a field-free point (FFP) generated by two solenoid coils was used. The SLP value in the quasi steady state (SLPqss) decreased with increasing Hs. The plot of the SLPqss values against the position from the FFP became narrow as the gradient strength of the SMF (Gs) increased. Conversely, it became broad as Gs decreased. These results suggest that the temperature rise and the area of local heating in magnetic hyperthermia can be controlled by varying the Hs and Gs values, respectively. In conclusion, our method will be useful for estimating the SLP in the presence of both the AMF and SMF and for designing an effective local heating system for magnetic hyperthermia in order to reduce the risk of overheating surrounding healthy tissues.


[1]  Abe, M., Hiraoka, M., Takahashi, M., Egawa, S., Matsuda, C., Onoyama, Y., Morita, K., Kakehi, M. and Sugahara, T. (1986) Multi-Institutional Studies on Hyperthermia Using an 8-MHz Radiofrequency Capacitive Heating Device (Thermotron RF-8) in Combination with Radiation for Cancer Therapy. Cancer, 58, 1589-1595.<1589::AID-CNCR2820580802>3.0.CO;2-B
[2]  Seip, R. and Ebbini, E.S. (1995) Noninvasive Estimation of Tissue Temperature Response to Heating Fields Using Diagnostic Ultrasound. IEEE Transactions on Biomedical Engineering, 42, 828-839.
[3]  Gilchrist, R.K., Medal, R., Shorey, W.D., Hanselman, R.C., Parrott, J.C. and Taylor, C.B. (1957) Selective Inductive Heating of Lymph Nodes. Annals of Surgery, 146, 596-606.
[4]  Jordan, A., Scholz, R., Maier-Hauff, K., Johannsen, M., Wust, P., Nodobny, J., Schirra, H., Schmidt, H., Deger, S., Loening, S., Lanksch, W. and Felix, R. (2001) Presentation of a New Magnetic Field Therapy System for the Treatment of Human Solid Tumors with Magnetic Fluid Hyperthermia. Journal of Magnetism and Magnetic Materials, 225, 118-126.
[5]  Murase, K., Aoki, M., Banura, N., Nishimoto, K., Mimura, A., Kuboyabu, T. and Yabata, I. (2015) Usefulness of Magnetic Particle Imaging for Predicting the Therapeutic Effect of Magnetic Hyperthermia. Open Journal of Medical Imaging, 5, 85-99.
[6]  Rosensweig, R.E. (2002) Heating Magnetic Fluid with Alternating Magnetic Field. Journal of Magnetism and Magnetic Materials, 252, 370-374.
[7]  Neuberger, T., Schopf, B., Hofmann, H., Hofmann, M. and von Rechenberga, B. (2005) Superparamagnetic Nanoparticles for Biomedical Applications: Possibilities and Limitations of a New Drug Delivery System. Journal of Magnetism and Magnetic Materials, 293, 483-496.
[8]  Ito, A., Shinkai, M., Honda, H. and Kobayashi, T. (2005) Medical Applications of Functionalized Magnetic Nanoparticles. Journal of Bioscience and Bioengineering, 100, 1-11.
[9]  Lee, J.H., Jang, J.T., Choi, J.S., Moon, S.H., Noh, S.H., Kim, J.W., Kim, I.S., Park, K.I. and Cheon, J. (2011) Exchange-Coupled Magnetic Nanoparticles for Efficient Heat Induction. Nature Nanotechnology, 6, 418-422.
[10]  Kuboyabu, T., Yamawaki, M., Aoki, M., Ohki, A. and Murase, K. (2016) Quantitative Evaluation of Tumor Early Response to Magnetic Hyperthermia Combined with Vascular Disrupting Therapy Using Magnetic Particle Imaging. International Journal of Nanomedicine and Nanosurgery, 2, 1-7.
[11]  Ohki, A., Kuboyabu, T., Aoki, M., Yamawaki, M. and Murase, K. (2016) Quantitative Evaluation of Tumor Response to Combination of Magnetic Hyperthermia Treatment and Radiation Therapy Using Magnetic Particle Imaging. International Journal of Nanomedicine and Nanosurgery, 2, 1-6.
[12]  Soto-Aquino, D. and Rinaldi, C. (2010) Magnetoviscosity in Dilute Ferrofluids from Rotational Brownian Dynamics Simulations. Physical Review E, 82, Article ID: 046310.
[13]  Murase, K. (2016) Methods for Estimating Specific Loss Power in Magnetic Hyperthermia Revisited. Open Journal of Applied Sciences, 6, 815-825.
[14]  Shliomis, M.I. (1972) Effective Viscosity of Magnetic Suspensions. Soviet Physics JETP, 34, 1291-1294.
[15]  Tasci, T.O., Vargel, I., Arat, A., Guzel, E., Korkusuz, P. and Atalar, E. (2009) Focused RF Hyperthermia Using Magnetic Fluids. Medical Physics, 36, 1906-1912.
[16]  Murase, K., Takata, H., Takeuchi, Y. and Saito, S. (2013) Control of the Temperature Rise in Magnetic Hyperthermia with Use of an External Static Magnetic Field. Physica Medica, 29, 624-630.
[17]  Press, W.H., Teukolsky, S.A., Vetterling, W.T. and Flannery, B.P. (1992) Numerical Recipes in C. Cambridge University Press, Oxford.
[18]  Murase, K., Oonoki, J., Takata, H., Song, R., Angraini, A., Ausanai, P. and Matsushita, T. (2011) Simulation and Experimental Studies on Magnetic Hyperthermia with Use of Superparamagnetic Iron Oxide Nanoparticles. Radiological Physics and Technology, 4, 194-202.
[19]  Maenosono, S. and Saita, S. (2006) Theoretical Assessment of FePt Nanoparticles as Heating Elements for Magnetic Hyperthermia. IEEE Transactions on Magnetism, 42, 1638-1642.
[20]  Jackson, J.D. (1999) Classical Electrodynamics. Wiley, New York.
[21]  Dhavalikar, R. and Rinaldi, C. (2016) Theoretical Predictions for Spatially-Focused Heating of Magnetic Nanoparticles Guided by Magnetic Particle Imaging Field Gradients. Journal of Magnetism and Magnetic Materials, 419, 267-273.
[22]  Martsenyuk, M.A., Raikher, Y.L. and Shliomis, M.I. (1974) On the Kinetics of Magnetization of Ferromagnetic Particle Suspension. Soviet Physics JETP, 38, 413-416.


comments powered by Disqus