All Title Author
Keywords Abstract


The Impact of Ethnicity on the Incidence, Tumor Characteristics and Treatment of Ductal Carcinoma in Situ—An 11-Year Clinical Experience at a High Volume Teaching Hospital

DOI: 10.4236/ss.2016.78050, PP. 348-356

Keywords: Ductal Carcinoma in Situ, HER-2/Neu, Ethnicity, Race, Breast Neoplasms

Full-Text   Cite this paper   Add to My Lib

Abstract:

Introduction: Screening mammography has led to a marked increase in detection of in situ breast tumors in the United States. The University of Southern California/Van Nuys Prognostic Index (USC/VNPI) predicts the recurrence rates of ductal carcinoma in situ (DCIS); however variations in tumor characteristics, USC/VNPI scores, receptor and human epithelial growth factor receptor (HER)-2/neu status across different ethnicities/races have not been well studied. This study aimed to evaluate the racial trends in incidence, patient demographics, tumor characteristics and treatment variations for patients with DCIS at a high volume teaching hospital. Methods: 395 women underwent surgical intervention for DCIS between 2000 and 2011. Their race/ethnicity was divided into five mutually exclusive categories and demographic and clinicopathological data was collected. Multivariate analysis was performed to evaluate variations in patient and tumor factors with respect to age, size and surgical management among different ethnicities and races. Results: 82.1% of Caucasian women underwent simple mastectomy with sentinel lymph node biopsy (SLNB) while lumpectomy with SLNB was highest in Hispanics (40%, p = 0.005). Overall, there was no significant difference in the incidence of receptor or HER-2/neu

References

[1]  Lippman, M. (2002) Why Study Ductal Carcinoma In-Situ? In: Silverstein, M.J., Recht, A. and Lagios, M., Eds., Ductal Carcinoma In-Situ of the Breast, 2nd Edition, Lippincott William and Wilkins, Philadelphia, 12-16.
[2]  Liao, N., Zhang, G., Liu, Y., Li, X., Yao, M., Xu, F., et al. (2011) HER2-Positive Status Is an Independent Predictor for Coexisting Invasion of Ductal Carcinoma in Situ of the Breast Presenting Extensive DCIS Component. Pathology Research and Practice, 207, 1-7.
http://dx.doi.org/10.1016/j.prp.2010.08.005
[3]  Joslyn, S.A. (2006) Ductal Carcinoma in Situ: Trends in Geographic, Temporal, and Demographic Patterns of Care and Survival. The Breast Journal, 12, 20-27.
http://dx.doi.org/10.1111/j.1075-122X.2006.00182.x
[4]  Blackman, D.K., Bennett, E.M. and Miller, D.S. (1999) Trends in Self-Reported Use of Mammograms (1989-1997) and Papanicolaou Tests (1991-1997)—Behavioral Risk Factor Surveillance System. MMWR Surveillance Summaries, 48, 1-22.
[5]  Desantis, C., Siegel, R., Bandi, P. and Jemal, A. (2011) Breast Cancer Statistics, 2011. CA: A Cancer Journal for Clinicians, 61, 409-418.
http://dx.doi.org/10.3322/caac.20134
[6]  Kim, J.A., Son, E.J., Youlk, J.H., Kim, E.K., Kim, M.J., Kwak, J.Y., et al. (2011) MRI Findings of Pure Ductal Carcinoma in Situ: Kinetic Characteristics Compared According to Lesion Type and Histopathologic Factors. American Journal of Roentgenology, 196, 1450-1456.
http://dx.doi.org/10.2214/AJR.10.5027
[7]  Silverstein, M.J. and Lagios, M.D. (2010) Ductal Carcinoma in Situ. In: Kuerer, H.M., Kuerer’s Breast Surgical Oncology, The McGraw Hill Companies, New York, 189-208.
[8]  Virnig, B.A., Tuttle, T.M., Shamliyan, T. and Kane, R.L. (2010) Ductal Carcinoma in Situ of the Breast: A Systematic Review of Incidence, Treatment, and Outcomes. Journal of the National Cancer Institute, 102, 170-178.
http://dx.doi.org/10.1093/jnci/djp482
[9]  Liu, L., Zhang, J., Wu, A.H., Pike, M.C. and Deapen, D. (2011) Invasive Breast Cancer Incidence Trends by Detailed Race/Ethnicity and Age. International Journal of Cancer, 130, 395-404.
http://dx.doi.org/10.1002/ijc.26004
[10]  Breast Cancer. American Cancer Society.
http://www.cancer.org/acs/groups/cid/documents/webcontent/003090-pdf.pdf
[11]  Schmale, I., Liu, S., Rayhanabad, J., Russell, C.A. and Sener, S.F. (2012) Ductal Carcinoma in Situ (DCIS) of the Breast: Perspectives on Biology and Controversies in Current Management. Journal of Surgical Oncology, 105, 212-220.
http://dx.doi.org/10.1002/jso.22020
[12]  Ernster, V.L., Barclay, J., Kerlikowske, K., Wilkie, H. and Ballard-Barbash, R. (2000) Mortality among Women with Ductal Carcinoma in Situ of the Breast in the Population Based Surveillance, Epidemiology and End Results Program. Archives of Internal Medicine, 160, 953-958.
http://dx.doi.org/10.1001/archinte.160.7.953
[13]  Schwartz, G.F., Solin, L.J., Olivotto, I.A., Ernster, V.L., Pressman, P., et al. (2000) The Consensus Conference on the Treatment of In Situ Ductal Carcinoma of the Breast, 22-25 April 1999. Breast, 9, 144-186.
http://dx.doi.org/10.1054/brst.1999.0156
[14]  Ernster, V.L., Barclay, J., Kerlikowski, K., Grady, D. and Henderson, I.C. (1996) Incidence of and Treatment for Ductal Carcinoma in Situ of the Breast. JAMA, 275, 913-918.
http://dx.doi.org/10.1001/jama.1996.03530360023033
[15]  Swanson, G.M., Ragheb, N.E., Lin, C.S., Hankey, B.F., Miller, B., Horn-Ross, P., et al. (1993) Breast Cancer among Black and White Women in the 1980s. Cancer, 72, 788-798.
http://dx.doi.org/10.1002/1097-0142(19930801)72:3<788::AID-CNCR2820720326>3.0.CO;2-C
[16]  Simon, M., Schwartz, A., Martino, S. and Swanson, G. (1992) Trends in the Diagnosis of in Situ Breast Cancer in the Detroit Metropolitan Area, 1973-1987. Cancer, 69, 466-469.
http://dx.doi.org/10.1002/1097-0142(19920115)69:2<466::AID-CNCR2820690232>3.0.CO;2-7
[17]  Silverstein, M.J. (2003) The University of Southern California/Van Nuys Prognostic Index for Ductal Carcinoma in Situ of the Breast. The American Journal of Surgery, 186, 337-343.
http://dx.doi.org/10.1016/S0002-9610(03)00265-4
[18]  Silverstein, M.J., Lagios, M.D., Recht, A., Allred, D.C., Harms, S.E., Holland, R., et al. (2005) Image Detected Breast Cancer: State of the Art Diagnosis and Treatment. Journal of the American College of Surgeons, 201, 586-597.
http://dx.doi.org/10.1016/j.jamcollsurg.2005.05.032
[19]  Adams-Cameron, M., Gilliland, F.D., Hunt, W.C. and Key, C.R. (1999) Trends in Incidence and Treatment for Ductal Carcinoma in Situ in Hispanic, American Indian, and Non-Hispanic White Women in New Mexico, 1973-1994. Cancer, 85, 1084-1090.
http://dx.doi.org/10.1002/(SICI)1097-0142(19990301)85:5<1084::AID-CNCR11>3.0.CO;2-5
[20]  Nassar, H., Bashar, S., Visvanathan, K. and Visscher, D. (2009) Ductal Carcinoma in Situ in African American versus Caucasian American Women: Analysis of Clinicopathologic Features and Outcome. Cancer, 115, 3181-3188.
http://dx.doi.org/10.1002/cncr.24376
[21]  Innos, K. and Horn-Ross, P.L. (2003) Recent Trends and Racial/Ethnic Differences in the Incidence and Treatment of Ductal Carcinoma in Situ of the Breast in California Women. Cancer, 97, 1099-1106.
http://dx.doi.org/10.1002/cncr.11104
[22]  Claus, E.B., Petruzella, S., Matloff, E. and Carter, D. (2005) Prevalence of BRCA1 and BRCA2 Mutations in Women Diagnosed with Ductal Carcinoma in Situ. JAMA, 293, 964-969.
http://dx.doi.org/10.1001/jama.293.8.964
[23]  Peto, J., Collins, N., Barfoot, R., Seal, S., Warren, W., Rahman, N., et al. (1999) Prevalence of BRCA1 and BRCA2 Gene Mutations in Patients with Early-Onset Breast Cancer. Journal of the National Cancer Institute, 93, 1811-1817.
http://dx.doi.org/10.1093/jnci/91.11.943
[24]  Innos, K. and Horn-Ross, P.L. (2008) Risk of Second Primary Breast Cancers among Women with Ductal Carcinoma in Situ of the Breast. Breast Cancer Research and Treatment, 111, 531-540.
http://dx.doi.org/10.1007/s10549-007-9807-1
[25]  Nattinger, A.B., Gottlieb, M.S., Veum, J., Yahnke, D. and Goodwin, J.S. (1992) Geographic Variation in the Use of Breast-Conserving Treatment for Breast Cancer. The New England Journal of Medicine, 326, 1102-1107.
http://dx.doi.org/10.1056/NEJM199204233261702
[26]  Katz, S.J., Lantz, P.M., Janz, N.K., Fagerlin, A., Schwartz, K., Liu, L., et al. (2005) Patient Involvement in Surgery Treatment Decisions for Breast Cancer. Journal of Clinical Oncology, 23, 5526-5533.
http://dx.doi.org/10.1200/JCO.2005.06.217
[27]  Tseng, J.F., Kronowitz, S.J., Sunn, C.C., Perry, A.C., Hunt, K.K., Babiera, G.V., et al. (2004) The Effect of Ethnicity on Immediate Reconstruction Rates after Mastectomy for Breast Cancer. Cancer, 101, 1514-1523.
http://dx.doi.org/10.1002/cncr.20529
[28]  Jackson, L.C., Camacho, F., Levine, E.A., Anderson, R.T. and Stewart IV, J.H. (2008) Patterns of Care Analysis among Women with Ductal Carcinoma in Situ in North Carolina. The American Journal of Surgery, 195, 164-169.
http://dx.doi.org/10.1016/j.amjsurg.2007.10.001
[29]  Trivers, K.F., Lund, M.J., Porter, P.L., Liff, J.M., Flagg, E.W., Coates, R.J., et al. (2009) The Epidemiology of Triple-Negative Breast Cancer, Including Race. Cancer Causes & Control, 20, 1071-1082.
http://dx.doi.org/10.1007/s10552-009-9331-1

Full-Text

comments powered by Disqus