全部 标题 作者
关键词 摘要


Long Term Follow-Up of ABO Incompatible Kidney Transplantation—A Study from India

DOI: 10.4236/oalib.1102544, PP. 1-5

Keywords: ABO Incompatible Kidney Transplantation, India, Long Term

Full-Text   Cite this paper   Add to My Lib

Abstract:

Background: There is a need to do ABO incompatible kidney transplantation in a country like India where deceased donor transplantation is not common. More than 90% transplantations are done with living donors. Although short term results have been reported from 4 centers, there is paucity of data on long term follow-up of such patients. Methods: The data of 18 patients who had undergone ABO incompatible transplantation exceeding a follow-up of 12 months up to 66 months were analyzed. It was compared with the data of compatible kidney transplantation during the same period. Results: In both the groups, there was a similar incidence of urinary tract infection and gastroenteritis with complete recovery. Tuberculosis was successfully treated in 2 patients who had undergone ABO incompatible transplantation. The graft function was excellent with an average follow-up period of 38.2 months. There was no patient mortality during the follow-up period. Conclusion: The long term outcome of ABO incompatible kidney transplantation is similar to compatible kidney transplantation despite the increased incidence of short term complications.

References

[1]  Wilpert, J., Fischer, K., Pisarski, P., Wiech, T., Daskalakis, M., Ziegler, A., Neumann-Haefelin, E., Drognitz, O., Emmerich, F., Walz, G. and Geyer, M. (2010) Long-Term Outcome of ABO-Incompatible Living Donor Kidney Transplantation Based on Antigen-Specific Desensitization. An Observational Comparative Analysis. Nephrology Dialysis Transplantation, 25, 3778-3786.
http://dx.doi.org/10.1093/ndt/gfq229
[2]  Montgomery, J., Berger, J., Warren, D., James, N., Montgomery, R. and Segev, D. (2012) Outcomes of ABO-Incom- patible Kidney Transplantation in the United States. Transplantation, 1.
http://dx.doi.org/10.1097/TP.0b013e318245b2af
[3]  Uchida, J., Kuwabara, N., Machida, Y., Iwai, T., Naganuma, T., Kumada, N. and Nakatani, T. (2012) Excellent Outcomes of ABO-Incompatible Kidney Transplantation: A Single-Center Experience. Transplantation Proceedings, 44, 204-209.
http://dx.doi.org/10.1016/j.transproceed.2011.11.006
[4]  Oettl, T., Halter, J., Bachmann, A., Guerke, L., Infanti, L., Oertli, D., Mihatsch, M., Gratwohl, A., Steiger, J. and Dickenmann, M. (2008) ABO Blood Group-Incompatible Living Donor Kidney Transplantation: A Prospective, Single-Centre Analysis Including Serial Protocol Biopsies. Nephrology Dialysis Transplantation, 24, 298-303.
http://dx.doi.org/10.1093/ndt/gfn478
[5]  Lipshutz, G. (2011) ABO Blood Type—Incompatible Kidney Transplantation and Access to Organs. Archives of Surgery, 146, 453.
http://dx.doi.org/10.1001/archsurg.2011.40
[6]  Tanabe, K. (2007) Japanese Experience of ABO-Incompatible Living Kidney Transplantation. Transplantation, 84, S4-S7.
http://dx.doi.org/10.1097/01.tp.0000296008.08452.4c
[7]  Bhadauria, D., Goel, A., Kaul, A., Sharma, R., Gupta, A., Ruhela, V., Gupta, A., Vardhan, H. and Prasad, N. (2015) Cryptosporidium Infection after Renal Transplantation in an Endemic Area. Transplant Infectious Disease, 17, 48-55.
http://dx.doi.org/10.1111/tid.12336
[8]  John, G., Shankar, V., Abraham, A., Mukundan, U., Thomas, P. and Jacob, C. (2001) Risk Factors for Post-Transplant Tuberculosis. Kidney International, 60, 1148-1153.
http://dx.doi.org/10.1046/j.1523-1755.2001.0600031148.x
[9]  Iqbal, T., Naqvi, R. and Akhter, S.F. (2010) Frequency of Urinary Tract Infection in Renal Transplant Recipients and Effect on Graft Function. Journal of Pakistan Medical Association, 60, 826-829.
[10]  Shin, M. and Kim, S. (2011) ABO Incompatible Kidney Transplantation—Current Status and Uncertainties. Journal of Transplantation, 2011, 1-11.
http://dx.doi.org/10.1155/2011/970421
[11]  Habicht, A., Broker, V., Blume, C., Lorenzen, J., Schiffer, M., Richter, N., Klempnauer, J., Haller, H., Lehner, F. and Schwarz, A. (2011) Increase of Infectious Complications in ABO-Incompatible Kidney Transplant Recipients—A Single Centre Experience. Nephrology Dialysis Transplantation, 26, 4124-4131.
http://dx.doi.org/10.1093/ndt/gfr215
[12]  Ravichandran, R., Kanakaraj, A., Shakthivel, A. and Srinivas, C. (2012) ABO Incompatible Kidney Transplantation— A Single Center Experience. Indian Journal of Transplantation, 6, 103-106.
http://dx.doi.org/10.1016/j.ijt.2012.10.002
[13]  Virani, Z., Bhagat, A., Rajput, P., Shah, B., Pagar, S., Bala, S. and Dawane, V. (2014) Our Initial Experience with ABO-Incompatible Transplant. Indian Journal of Transplantation, 8, 132-133.
http://dx.doi.org/10.1016/j.ijt.2014.12.021
[14]  Jha, P.K., Bansal, S.B., Sethi, S.K., et al. (2015) ABO-Incompatible Renal Transplantation in Developing World— Crossing the Immunological (and Mental) Barrier. Indian Journal of Nephrology, 26, 113-118.
http://www.indianjnephrol.org/preprintarticle.asp?id=159557
[15]  Jha, V. (2013) Current Status of End-Stage Renal Disease Care in India and Pakistan. Kidney International Supplements, 3, 157-160.
http://dx.doi.org/10.1038/kisup.2013.3
[16]  Tobian, A., Shirey, R., Montgomery, R., Cai, W., Haas, M., Ness, P. and King, K. (2010) ABO Antibody Titer and Risk of Antibody-Mediated Rejection in ABO-Incompatible Renal Transplantation. American Journal of Transplantation, 10, 1247-1253.
http://dx.doi.org/10.1111/j.1600-6143.2010.03103.x

Full-Text

comments powered by Disqus