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中国中药杂志 2012

红景天苷对神经系统疾病药理作用的研究进展

谢卉,朱大会

Keywords: 葡糖苷类,红景天,神经系统,药理作用,进展

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Abstract:

红景天苷是植物红景天的提取物,也是其主要有效成分。近年研究发现红景天苷具有神经保护、清除自由基、调节中枢神经递质、促进神经修复及抗神经细胞凋亡等多种作用,有望应用于多种神经变性疾病及脑缺血性疾病。该文综述红景天苷对神经系统疾病的药理作用研究进展,为进一步研究、开发和利用红景天提供参考。

References

[1]	曹晓钢,于刚,王立军.红景天苷研究进展[J].食品与药品,2007,9(7):48.
[2]	Yu Sen,Liu Li,Wen Tao, et al. Development and validation of a liquid chromatographic/electrospray ionization mass spectrometric method for the determination of salidroside in rat plasma: application to the pharmacokinetics study[J]. J Chromatogr B,2008,861(1):10.
[3]	贾巍,王曼莉,杨长青.红景天苷在大鼠体内的药物动力学考察[J].沈阳药科大学学报,2010,27(1):65.
[4]	张宇红,陈生弟,李江林,等.红景天甙促进帕金森病模型小鼠表达内源性胶质细胞源性神经营养因子蛋白保护多巴胺能神经元[J].中华神经科杂志,2006,39(8):540.
[5]	Li Xiaofeng,Ye Xiaoli,Li Xiaobing,et al. Salidroside protects against MPP+-induced apoptosis in PC12 cells by inhibiting the NO pathway[J]. Brain Res,2011,1382(2):9.
[6]	张宇红,叶民,汪锡金,等.红景天甙对帕金森病模型小鼠PI3K/蛋白激酶B信号转导途径的影响[J].临床神经病学杂志,2008,21(2):133.
[7]	陈宏,陈建宗,厚荣荣,等.红景天苷对百草枯所致PC12细胞凋亡的抑制作用及相关机制[J].中国药理学与毒理学杂志,2007,21(3):190.
[8]	陈妙娟,邢达,陈同生.利用FRET技术在活细胞内研究红景天甙对Aβ25-35诱导PC12细胞凋亡的抑制作用[J].生物物理学报,2006,22(6):415.
[9]	Hoi Chu Peng,Ho Yee Ping,Baum Larry,et al. Neuroprotective effect of honokiol and magnolol,compounds from Magnolia officinalis,on beta-amyloid-induced toxicity in PC12 cells[J]. Phytother Res,2010,24(10):1538.
[10]	Yu Shu,Shen Yuntian,Liu Jie,et al. Involvement of ERK1/2 pathway in neuroprotection by salidroside against hydrogen peroxide-induced apoptotic cell death[J]. J Mole Neurosci,2010,40(3):321.
[11]	曹立莉,杜冠华,王敏伟.红景天苷减轻叠氮钠诱导线粒体损伤的作用[J].药学学报,2005,40(8):700.
[12]	谢桂琴,孙秀兰,田苏平,等.红景天素对实验性老年性痴呆大鼠防治作用的研究[J].中国行为医学科学,2003,12(1):18.
[13]	陈燕清,李丽.红景天对血管性痴呆大鼠海马组织AchE及神经元凋亡影响的实验研究[J].世界中西医结合杂志,2008,3(1):20.
[14]	赵珩,蔺勇,程永杰,等.红景天苷对糖尿病脑病模型大鼠学习记忆功能的影响[J].中国实验诊断学,2010,14(11):1722.
[15]	杨江河,李华,修彬华,等. 红景天苷对高原缺氧大鼠认知功能障碍的治疗作用及其可能机制[J]. 现代生物医学进展,2011(11):2026.
[16]	贾莹,颜天华,王秋娟,等. 红景天苷对麻醉犬脑循环及大鼠全脑缺血再灌注的影响[J]. 中国药科大学报,2008,39(1):77.
[17]	邹毅清,蔡志扬,毛燕飞,等.红景天苷预处理对大鼠全脑缺血再灌注后神经行为学的影响[J].中西医结合学报,2009,7(2):130.
[18]	Xia Chen,Qi Zhang,Qiong Cheng,et al. Protective effect of salidroside against H2O2-induced cell apoptosis in primary culture of rat hippocampal neurons[J]. Mol Cell Biochem,2009,332(1):85.
[19]	Kishan G R. Herbal drugs:ethno medicine to modern medicine[M].German:Springer,2009:293.
[20]	刘晓梅,田国忠.红景天苷对局灶性脑缺血再灌注大鼠突触超微结构的影响[J].解剖学研究,2009,31(5):353.
[21]	刘晓梅,董美蓉,王景霞.红景天苷对局灶性脑缺血再灌注大鼠神经生长相关蛋白的影响[J].解剖学研究,2009,31(4):241.
[22]	刘晓梅,刘斌,陈尚.红景天苷对局灶性脑缺血再灌注大鼠神经可塑性的影响[J].中国中医药科技,2010,17(1):27.
[23]	刘晓梅,王淑英,刘斌. 红景天苷对脑缺血再灌注大鼠脑神经元APE/Ref-1的影响[J]. 中国老年医学杂志,2009,29(5):518.
[24]	Erin Wei Qian,Daniel Tianfang Ge,Siu Kai Kong. Salidroside promotes erythropoiesis and protects erythroblasts against oxidative stress by up-regulating glutathione peroxidase and thioredoxin[J]. J Ethnopharmacol,2011,133(2):308.
[25]	秦亚静,曾园山,周春春,等.红景天对慢性应激导致的抑郁大鼠大脑海马5-羟色胺水平及其细胞增殖、分化和神经元数量的影响[J].中国中药杂志,2008,33(23):2842.
[26]	Mattioli L,Funari C,Perfumi M. Effects of Rhodiola rosea L. extract on behavioural and physiological alterations induced by chronic mild stress in female rats[J]. J Psychopharmacol,2009,23(2):130.
[27]	刘晓晖,张莉,张岭,等.红景天苷对慢性重复悬尾应激动物的保护作用[J].中国实验方剂学杂志,2011,17(9):199.
[28]	明海泉,夏光成,张瑞钧. 红景天研究进展[J]. 中草药,1988(19):229.
[29]	Li Tingli,Xu Guanghui,Wu Lili,et a1. Pharmacological studies on the sedative and hypnotic effect of salidroside from the Chinese medicinal plant Rhodiola sachalinesis[J]. Phytomedicine,2007,14(9):601.
[30]	陈巧格,曾园山,唐久余,等.红景天镇静催眠作用的实验研究[J].解剖学研究,2008,30(5):351.
[31]	许光辉,李廷利,郭冷秋,等.红景天苷对失眠大鼠睡眠周期的影响[J].医学研究生学报,2008,21(10):1036.
[32]	杨晓艳,娄灯吉,芦启琴,等. 红景天胶囊对小鼠抗应激作用的实验研究[J]. 食品科学,2009,30(11):240.
[33]	童本德,马莉,蔡东联,等. 红景天苷对不同状态下小鼠能量代谢的影响[J]. 中国临床营养杂志,2008,16(6):357.
[34]	王昊,季宇彬,汲晨锋.红景天苷对运动疲劳大鼠神经递质影响研究[J].哈尔滨商业大学学报:自然科学版,2011,27(1):1.
[35]	Huang Shin Chung,Lee Fang Tsai,Yang Joan Hwa,et al. Attenuation of long-term Rhodiola rosea supplementation on exhaustive swimming-evoked oxidative stress in the rat[J]. Chin J Physiol,2009,52(5):316.
[36]	耿欣,汲晨锋,季宇彬.红景天苷对运动疲劳大鼠红细胞膜的影响[J].中药药理与临床,2008,24(1):158.
[37]	王群,王坚,孙玲君,等.红景天苷对负性心理应激下模拟航渡并高强度运动雄性大鼠下丘脑-垂体-性腺轴的调节[J].中华男科学杂志,2009,15(4):331.
[38]	关磐石,杨建新,李国标.红景天苷对手术后疲劳大鼠模型的影响[J].广州医药,2009,40(5):49.
[39]	关磐石,李国标. 红景天苷对手术应激大鼠垂体生长激素的影响[J]. 长江大学学报:自科版,2010,7(1):9.
[40]	Guan Shuang,He Jiakang, Guo Weixiao,et al. Adjuvant effects of salidroside from Rhodiola rosea L. on the immune responses to ovalbumin in mice[J]. Immunopharmacol Immunotoxicol,2011,33(2):1.
[41]	Chou Lin Shih-Shen,Chin Lengsu William,Chao Pei-Chun,et al. In vivo Th1 and Th2 cytokine modulation effects of Rhodiola rosea standardised solution and its major constituent,salidroside[J]. Phytother Res,2011,25(10):870.
[42]	叶莎莎,曾耀英,尹乐乐.红景天苷对小鼠腹腔巨噬细胞体外增殖、凋亡、吞噬、ROS和NO产生的影响[J].细胞与分子免疫学杂志,2011,27(3):237.
[43]	裴品品,吴润,赵红斌,等. Ca2+信号介导红景天苷促进小鼠骨髓间充质干细胞向神经细胞的定向分化[J]. 中国组织工程研究与临床康复,2010,24(14):1808.
[44]	Darbinyan V,Kteyan A,Panossian A,et al. Rhodiola rosea in stress induced fatigue-A double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty[J]. Phytomedicine,2000,7(5):365.
[45]	Spasov A A,Wikman G K, Mandrikov V B,et al. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen[J]. Phytomedicine,2000,7(2):85.
[46]	Shevtsov V A,Zholus B I,Shervarly V I,et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work[J]. Phytomedicine,2003,10(2):95.
[47]	Darbinyan V,Aslanyan G,Amroyan E,et al. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression[J]. Nord J Psychiatr,2007,61(5):343.
[48]	姜平,黄立成,寇星灿,等.藏药狭叶红景天的急性毒性与蓄积毒性实验[J].辽宁中医杂志,1995,22(10):475.
[49]	贾国夫,何正军,尼科,等. 红景天软胶囊毒理学试验研究[J]. 草业与畜牧,2010,24(12):3.
[50]	朱玉平,张天宝,万旭英,等.红景天苷注射液遗传毒性的研究[J].药学服务与研究,2009,9(4):279.
[51]	王惠琴,孔祥环,蒋致诚,等.大鼠口服红景天致畸作用的研究[J].首都医学院学报,1993,14(2):90.
[52]	曹第勇,周春阳,刘毅,等.圣地红景天长期毒性试验[J].川北医学院学报,1998,13(1):10.

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