A commutative Rota-Baxter algebra can be regarded as a commutative algebra that carries an abstraction of the integral operator. With the motivation of generalizing the study of algebraic geometry to Rota-Baxter algebra, we extend the central concept of localization for commutative algebras to commutative Rota-Baxter algebras. The existence of such a localization is proved and, under mild conditions, its explicit constructions are obtained. The existence of tensor products of commutative Rota-Baxter algebras is also proved and the compatibility of localization and tensor product of Rota-Baxter algebras is established. We further study Rota-Baxter coverings and show that they form a Gr\"othendieck topology.